PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31832810-0	2020	6-Gingerol induces cell-cycle G1-phase arrest through AKT-GSK 3beta-cyclin D1 pathway in renal-cell carcinoma.	gingerol	0-10	cyclin D1	Homo sapiens	68-77	
31832810-7	2020	Western-blotting results showed that 6-gingerol reduces phosphorylation of protein kinase B (AKT) Ser 473, cyclin-dependent kinases (CDK4), and cyclin D1 and, meanwhile, increases glycogen synthase kinase (GSK 3beta) protein amount.	gingerol	37-47	cyclin D1	Homo sapiens	144-153	
31832810-9	2020	CONCLUSION: The above results indicate that 6-gingerol can induce cell-cycle arrest and cell-growth inhibition through the AKT-GSK 3beta-cyclin D1 signaling pathway in vitro and in vivo, suggesting that 6-gingerol should be useful for renal-cell carcinoma treatment.	gingerol	44-54	cyclin D1	Homo sapiens	137-146	
31832810-9	2020	CONCLUSION: The above results indicate that 6-gingerol can induce cell-cycle arrest and cell-growth inhibition through the AKT-GSK 3beta-cyclin D1 signaling pathway in vitro and in vivo, suggesting that 6-gingerol should be useful for renal-cell carcinoma treatment.	gingerol	203-213	cyclin D1	Homo sapiens	137-146	
30187878-9	2018	10-gingerol at 1, 3, and 10 mumol/L significantly decreased the mRNA expressions of cyclin D1 and CMCC as shown by qPCR (P < 0.01).	gingerol	0-11	cyclin D1	Homo sapiens	84-93	
18058799-7	2008	Subsequently, 6-gingerol suppressed cyclin D1 expression and induced NAG-1 expression.	gingerol	14-24	cyclin D1	Homo sapiens	36-45	
18058799-10	2008	The results suggest that 6-gingerol stimulates apoptosis through upregulation of NAG-1 and G(1) cell cycle arrest through downregulation of cyclin D1.	gingerol	25-35	cyclin D1	Homo sapiens	140-149