PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15980231-6 2005 RESULTS: PTM and PCB cells treated with lovastatin or compactin exhibited dramatic changes in cell shape and cytoskeletal organization within 24 hours, consisting of cell rounding, actin depolymerization, and decreased focal adhesions. Lovastatin 40-50 pyruvate carboxylase Homo sapiens 17-20 15980231-8 2005 Both lovastatin and compactin decreased MLC phosphorylation in PTM and PCB cells. Lovastatin 5-15 pyruvate carboxylase Homo sapiens 71-74 15980231-11 2005 CONCLUSIONS: This study demonstrates that the statin drugs lovastatin and compactin induce changes in cell shape and actin cytoskeletal organization and decrease MLC phosphorylation in PTM and PCB cells, all of which are events that are likely to lead to cellular and tissue relaxation. Lovastatin 59-69 pyruvate carboxylase Homo sapiens 193-196