PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30846365-0 2019 Phase II Study of Tivantinib and Cetuximab in Patients With KRAS Wild-type Metastatic Colorectal Cancer With Acquired Resistance to EGFR Inhibitors and Emergence of MET Overexpression: Lesson Learned for Future Trials With EGFR/MET Dual Inhibition. ARQ 197 18-28 epidermal growth factor receptor Homo sapiens 132-136 30846365-2 2019 Combining tivantinib, an inhibitor of the MET receptor tyrosine kinase, and cetuximab may be effective in patients with epidermal growth factor receptor-resistant MET-high mCRC. ARQ 197 10-20 epidermal growth factor receptor Homo sapiens 120-152 26153496-14 2015 Although this study lacked statistical power because of the premature termination and did not demonstrate an improvement in OS, our results suggest that tivantinib plus erlotinib might improve PFS than erlotinib alone in nonsquamous NSCLC patients with WT-EGFR. ARQ 197 153-163 epidermal growth factor receptor Homo sapiens 256-260 27843623-0 2016 Phase II study of erlotinib plus tivantinib (ARQ 197) in patients with locally advanced or metastatic EGFR mutation-positive non-small-cell lung cancer just after progression on EGFR-TKI, gefitinib or erlotinib. ARQ 197 33-43 epidermal growth factor receptor Homo sapiens 102-106 27843623-4 2016 This study evaluated the efficacy and safety of a c-Met selective inhibitor, tivantinib (ARQ 197), in combination with erlotinib, in Japanese EGFR mutation-positive patients with NSCLC who progressed while on EGFR-TKIs. ARQ 197 77-87 epidermal growth factor receptor Homo sapiens 142-146 29288764-0 2018 Tivantinib in Combination with Erlotinib versus Erlotinib Alone for EGFR-Mutant NSCLC: An Exploratory Analysis of the Phase 3 MARQUEE Study. ARQ 197 0-10 epidermal growth factor receptor Homo sapiens 68-72 29288764-1 2018 INTRODUCTION: This exploratory subgroup analysis of the MARQUEE study evaluated the efficacy and safety of erlotinib plus tivantinib in patients with EGFR-mutant NSCLC. ARQ 197 122-132 epidermal growth factor receptor Homo sapiens 150-154 29288764-9 2018 CONCLUSIONS: Erlotinib plus tivantinib was tolerable and showed improved efficacy over erlotinib monotherapy in previously treated EGFR-mutant NSCLC. ARQ 197 28-38 epidermal growth factor receptor Homo sapiens 131-135