PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35069549-7 2021 Results: Pretreatment with SMS ameliorated MSU-induced acute gouty arthritis in mice with increased PI3K/Akt activation and M2 macrophage polarization in the joint tissues. sms 27-30 thymoma viral proto-oncogene 1 Mus musculus 105-108 35069549-8 2021 In vitro, SMS treatment significantly inhibited MSU-triggered inflammatory response, increased p-Akt and Arg-1 expression in macrophages, and promoted M2 macrophage polarization. sms 10-13 thymoma viral proto-oncogene 1 Mus musculus 97-100 35069549-13 2021 The anti-inflammatory mechanism of SMS may exert anti-inflammatory effects by promoting M2 polarization via PI3K/Akt signaling. sms 35-38 thymoma viral proto-oncogene 1 Mus musculus 113-116