PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10403802-2 1999 L-Asparaginase preparation derived from E. coli converts asparagine (Asn) and glutamine (Gln) to aspartate (Asp) and glutamate (Glu), respectively, and causes rapid depletion of Asn and Gln. Aspartic Acid 97-106 asparaginase and isoaspartyl peptidase 1 Homo sapiens 0-14 16892900-2 2006 L-asparaginase leads to enzymatic cleavage of L-asparagine (amino acid essential for lymphoblasts" growth) to ammonia and L-aspartic acid, what results in depletion of L-asparagine in a serum and cerebrospinal fluid, and finally leads to destruction of lymphoblasts, which lack ability of endogenic L-asparagine production. Aspartic Acid 122-137 asparaginase and isoaspartyl peptidase 1 Homo sapiens 0-14 16260050-3 2006 The fusion partner gene with 127 amino acid residues of the C-terminus from L-asparaginase was recombined respectively with asp-pro-pro-hGHRH(1-44), asp-pro-hGHRH(1-44) or asp-1pro-GHRH(2-44) genes synthesized by PCR method to form three kinds of fusion proteins with unique acid labile linker Asp-Pro. Aspartic Acid 294-297 asparaginase and isoaspartyl peptidase 1 Homo sapiens 76-90 17717965-8 2006 Native or pegylated L-asparaginase (ASNase or PEG-ASNase) are highly specific for the deamination of L-asparagine (Asn) to aspartic acid and ammonia. Aspartic Acid 123-136 asparaginase and isoaspartyl peptidase 1 Homo sapiens 20-34 12142634-2 2002 L-Asparagine is an essential amino acid for many lymphoid tumor cells and L-asparaginase catalyzes its conversion to L-aspartic acid and ammonia. Aspartic Acid 117-132 asparaginase and isoaspartyl peptidase 1 Homo sapiens 74-88 34249720-1 2021 Background: The enzyme L-asparaginase (ASRGL1) catalyzes the hydrolysis of L-asparagine (Asn) to L-aspartic acid (Asp) and ammonia. Aspartic Acid 97-112 asparaginase and isoaspartyl peptidase 1 Homo sapiens 39-45 34728685-1 2021 L-asparaginase (ASNase, EC 3.5.1.1) is an enzyme that catalyzes the L-asparagine hydrolysis into L-aspartic acid and ammonia, being mainly applied in pharmaceutical and food industries. Aspartic Acid 97-112 asparaginase and isoaspartyl peptidase 1 Homo sapiens 0-14 34728685-1 2021 L-asparaginase (ASNase, EC 3.5.1.1) is an enzyme that catalyzes the L-asparagine hydrolysis into L-aspartic acid and ammonia, being mainly applied in pharmaceutical and food industries. Aspartic Acid 97-112 asparaginase and isoaspartyl peptidase 1 Homo sapiens 16-22 34249720-1 2021 Background: The enzyme L-asparaginase (ASRGL1) catalyzes the hydrolysis of L-asparagine (Asn) to L-aspartic acid (Asp) and ammonia. Aspartic Acid 114-117 asparaginase and isoaspartyl peptidase 1 Homo sapiens 39-45 34076169-1 2021 L-Asparaginase catalysing the breakdown of L-Asparagine to L-Aspartate and ammonia is an enzyme of therapeutic importance in the treatment of cancer, especially the lymphomas and leukaemia. Aspartic Acid 59-70 asparaginase and isoaspartyl peptidase 1 Homo sapiens 0-14 33911966-1 2021 L-Asparaginase is an antileukemic agent that depletes L-asparagine "an important nutrient for cancer cells" through the hydrolysis of L-asparagine into L-aspartic acid and ammonia leading to leukemia cell starvation and apoptosis in susceptible leukemic cell populations. Aspartic Acid 152-167 asparaginase and isoaspartyl peptidase 1 Homo sapiens 0-14 27885727-0 2017 Growth inhibitory and proapoptotic effects of l-asparaginase from Fusarium culmorum ASP-87 on human leukemia cells (Jurkat). Aspartic Acid 84-87 asparaginase and isoaspartyl peptidase 1 Homo sapiens 46-60 32707027-1 2021 L-Asparaginase is an important enzyme which converts L-asparagine to L-aspartate and ammonia. Aspartic Acid 69-80 asparaginase and isoaspartyl peptidase 1 Homo sapiens 0-14 32020477-7 2020 L-asparaginase hydrolyzes asparagine into aspartate and depletes asparagine. Aspartic Acid 42-51 asparaginase and isoaspartyl peptidase 1 Homo sapiens 0-14 29299118-1 2017 L-Asparaginase (L-Asp) is an enzyme that catalyzes the hydrolysis of L-asparagine to L-aspartic acid, and its depletion induces leukemic cell death. Aspartic Acid 85-100 asparaginase and isoaspartyl peptidase 1 Homo sapiens 0-14 29299118-1 2017 L-Asparaginase (L-Asp) is an enzyme that catalyzes the hydrolysis of L-asparagine to L-aspartic acid, and its depletion induces leukemic cell death. Aspartic Acid 85-100 asparaginase and isoaspartyl peptidase 1 Homo sapiens 0-5 27885727-7 2017 l-asparaginase purified from F. culmorum ASP-87 showed significant and selective cytotoxic and apoptotic effects on human T-cell leukemic cells in dose-dependent manner. Aspartic Acid 41-44 asparaginase and isoaspartyl peptidase 1 Homo sapiens 0-14 28245869-9 2017 L-asparaginase, an enzyme that catalyzes the hydrolysis of asparagine and glutamine to aspartic acid and glutamate, respectively, mimics the effect of glutamine withdrawal and also diminished the proportion of SP cells. Aspartic Acid 87-100 asparaginase and isoaspartyl peptidase 1 Homo sapiens 0-14 26672444-1 2016 L-Asparaginase (L-asparagine amidohydrolase, EC 3.5.1.1) catalyzes the hydrolysis of L-asparagine to L-aspartic acid and ammonia. Aspartic Acid 101-116 asparaginase and isoaspartyl peptidase 1 Homo sapiens 0-14 27866936-1 2016 l-asparaginase (EC 3.5.1.1) is an enzyme that catalysis mainly the asparagine hydrolysis in l-aspartic acid and ammonium. Aspartic Acid 92-107 asparaginase and isoaspartyl peptidase 1 Homo sapiens 0-14 27452168-1 2016 l-Asparaginase, an enzyme that catalyzes l-asparagine into aspartic acid and ammonia, has relevant applications in the pharmaceutical and food industry. Aspartic Acid 59-72 asparaginase and isoaspartyl peptidase 1 Homo sapiens 0-14 27770857-1 2016 l-Asparaginase (EC 3.5.1.1) is an enzyme that catalyzes the hydrolysis of l-asparagine to l-aspartic acid. Aspartic Acid 90-105 asparaginase and isoaspartyl peptidase 1 Homo sapiens 0-14 26672444-1 2016 L-Asparaginase (L-asparagine amidohydrolase, EC 3.5.1.1) catalyzes the hydrolysis of L-asparagine to L-aspartic acid and ammonia. Aspartic Acid 101-116 asparaginase and isoaspartyl peptidase 1 Homo sapiens 16-43 21305874-1 2010 L-asparaginase catalyzes the hydrolysis of L-asparagine into aspartate and ammonia, which is used as an anti-neoplastic agent. Aspartic Acid 61-70 asparaginase and isoaspartyl peptidase 1 Homo sapiens 0-14 25177232-5 2014 Interestingly, intracellular asparagine was also depleted rapidly, and the mechanism was suggested to involve rapid export of intracellular asparagine followed by rapid conversion to aspartic acid by L-ASP. Aspartic Acid 183-196 asparaginase and isoaspartyl peptidase 1 Homo sapiens 200-205 22356135-6 2012 However, it may be overcome by continuous action of L-Asp, which is mirrored by increased aspartic acid levels but unchanged low asparagine levels in BM, suggesting a higher BM turnover of asparagine generated by L-Asp during induction therapy. Aspartic Acid 90-103 asparaginase and isoaspartyl peptidase 1 Homo sapiens 52-57 22944204-4 2012 The expression plasmid contained a gene fragment encoding the Tat-HA-NR2B9c was ligated to the C-terminal fragment of l-asparaginase (AnsB-C) via a unique acid labile Asp-Pro linker. Aspartic Acid 167-170 asparaginase and isoaspartyl peptidase 1 Homo sapiens 118-132 18823071-1 2009 A novel assay for the determination of l-asparaginase activity in human plasma is described that is based on the HPLC quantitation of l-aspartic acid produced during enzyme incubation. Aspartic Acid 134-149 asparaginase and isoaspartyl peptidase 1 Homo sapiens 39-53