PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11394910-4 2001 Coimmunoprecipitation assays demonstrated that the interaction of RbAp46 with BRCA1 requires the first two of the four Trp-Asp (WD)-repeats of RbAp46. Aspartic Acid 123-126 BRCA1 DNA repair associated Homo sapiens 78-83 30714292-0 2019 Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation. Aspartic Acid 93-102 BRCA1 DNA repair associated Homo sapiens 11-16 30714292-3 2019 Here, we identified several metabolic genes, including the gene which encodes glutamate-oxaloacetate transaminase 2 (GOT2), a key enzyme for aspartate biosynthesis, which are repressed by BRCA1. Aspartic Acid 141-150 BRCA1 DNA repair associated Homo sapiens 188-193 30714292-8 2019 In summary, our findings reveal that BRCA1 modulates aspartate biosynthesis through transcriptional repression of GOT2, and provides a biological basis for treatment choices in breast cancer. Aspartic Acid 53-62 BRCA1 DNA repair associated Homo sapiens 37-42