PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6924862-4	1982	The kallikrein has an unusual amino acid composition: aspartic acid and glutamic acid comprise 40% of the residues; the total number of basic residues is less than 5%; glycine and proline together make up more than 40% of the residues.	Aspartic Acid	54-67	kallikrein related peptidase 4	Homo sapiens	4-14	
12228221-6	2002	Our previous studies using point-mutated M-form PSTs established that the Mn(2+) (in the substrate-Mn(2+) complex) exerts its stimulatory effect by binding predominantly to the Asp-86 residue at the active site.	Aspartic Acid	177-180	kallikrein related peptidase 4	Homo sapiens	48-52	
3065335-11	1988	Key amino acid residues, His(41), Asp(96), and Ser(190), required for catalytic activity and Asp (184) required for kallikrein-type specificity are completely conserved.	Aspartic Acid	34-37	kallikrein related peptidase 4	Homo sapiens	116-126	
3065335-11	1988	Key amino acid residues, His(41), Asp(96), and Ser(190), required for catalytic activity and Asp (184) required for kallikrein-type specificity are completely conserved.	Aspartic Acid	93-96	kallikrein related peptidase 4	Homo sapiens	116-126	
3853975-6	1985	As expected, the amino acids required for catalytic activity are conserved as is the Asp residue required for the kallikrein-type specificity.	Aspartic Acid	85-88	kallikrein related peptidase 4	Homo sapiens	114-124	
17142774-5	2006	ASP produced VL activity from human plasma apparently through kallikrein/kinin system activation, suggesting that ASP can generate kinin in humans.	Aspartic Acid	0-3	kallikrein related peptidase 4	Homo sapiens	62-72	
17142774-6	2006	Consistent with the finding that a major part of the ASP-induced VL was reduced by a potent kallikrein inhibitor, soybean trypsin inhibitor that does not affect ASP enzymatic activity, ASP activated prekallikrein but not factor XII to generate kallikrein in a dose- and incubation time-dependent manner.	Aspartic Acid	53-56	kallikrein related peptidase 4	Homo sapiens	92-102	
17142774-6	2006	Consistent with the finding that a major part of the ASP-induced VL was reduced by a potent kallikrein inhibitor, soybean trypsin inhibitor that does not affect ASP enzymatic activity, ASP activated prekallikrein but not factor XII to generate kallikrein in a dose- and incubation time-dependent manner.	Aspartic Acid	53-56	kallikrein related peptidase 4	Homo sapiens	202-212