PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26518722-3 2015 In the context of antibody-mediated targeted cancer therapy, we evaluated the anti-tumor activity and therapeutic efficacy of Doxil, and that of Doxil modified with a monoclonal antibody (mAb) against CD44, which is one of the most well-known surface markers associated with Cancer Stem Cells (CSCs). liposomal doxorubicin 145-150 CD44 antigen Mus musculus 201-205 26518722-4 2015 Flow cytometry analyses and confocal laser scanning microscopy results showed significant enhanced cellular uptake of CD44-targeted Doxil (CD44-Doxil) in CD44-positive C-26 cells compared to Doxil. liposomal doxorubicin 132-137 CD44 antigen Mus musculus 118-122 26518722-4 2015 Flow cytometry analyses and confocal laser scanning microscopy results showed significant enhanced cellular uptake of CD44-targeted Doxil (CD44-Doxil) in CD44-positive C-26 cells compared to Doxil. liposomal doxorubicin 132-137 CD44 antigen Mus musculus 139-143 26518722-4 2015 Flow cytometry analyses and confocal laser scanning microscopy results showed significant enhanced cellular uptake of CD44-targeted Doxil (CD44-Doxil) in CD44-positive C-26 cells compared to Doxil. liposomal doxorubicin 132-137 CD44 antigen Mus musculus 139-143 26518722-4 2015 Flow cytometry analyses and confocal laser scanning microscopy results showed significant enhanced cellular uptake of CD44-targeted Doxil (CD44-Doxil) in CD44-positive C-26 cells compared to Doxil. liposomal doxorubicin 144-149 CD44 antigen Mus musculus 118-122 26518722-4 2015 Flow cytometry analyses and confocal laser scanning microscopy results showed significant enhanced cellular uptake of CD44-targeted Doxil (CD44-Doxil) in CD44-positive C-26 cells compared to Doxil. liposomal doxorubicin 144-149 CD44 antigen Mus musculus 139-143 26518722-4 2015 Flow cytometry analyses and confocal laser scanning microscopy results showed significant enhanced cellular uptake of CD44-targeted Doxil (CD44-Doxil) in CD44-positive C-26 cells compared to Doxil. liposomal doxorubicin 144-149 CD44 antigen Mus musculus 139-143 26518722-4 2015 Flow cytometry analyses and confocal laser scanning microscopy results showed significant enhanced cellular uptake of CD44-targeted Doxil (CD44-Doxil) in CD44-positive C-26 cells compared to Doxil. liposomal doxorubicin 144-149 CD44 antigen Mus musculus 118-122 26518722-4 2015 Flow cytometry analyses and confocal laser scanning microscopy results showed significant enhanced cellular uptake of CD44-targeted Doxil (CD44-Doxil) in CD44-positive C-26 cells compared to Doxil. liposomal doxorubicin 144-149 CD44 antigen Mus musculus 139-143 26518722-4 2015 Flow cytometry analyses and confocal laser scanning microscopy results showed significant enhanced cellular uptake of CD44-targeted Doxil (CD44-Doxil) in CD44-positive C-26 cells compared to Doxil. liposomal doxorubicin 144-149 CD44 antigen Mus musculus 139-143 26518722-5 2015 However, CD44-negative NIH-3T3 cells showed a similar uptake and in vitro cytotoxicity with both CD44-Doxil and non-targeted Doxil. liposomal doxorubicin 101-107 CD44 antigen Mus musculus 9-13 26518722-5 2015 However, CD44-negative NIH-3T3 cells showed a similar uptake and in vitro cytotoxicity with both CD44-Doxil and non-targeted Doxil. liposomal doxorubicin 102-107 CD44 antigen Mus musculus 9-13 26518722-5 2015 However, CD44-negative NIH-3T3 cells showed a similar uptake and in vitro cytotoxicity with both CD44-Doxil and non-targeted Doxil. liposomal doxorubicin 102-107 CD44 antigen Mus musculus 97-101 26518722-6 2015 In BALB/c mice bearing C-26 murine carcinoma, CD44-Doxil groups exhibited significantly higher doxorubicin concentration (than Doxil) inside the tumor cells, while their circulation time and distribution profile remained comparable. liposomal doxorubicin 51-56 CD44 antigen Mus musculus 46-50 26518722-6 2015 In BALB/c mice bearing C-26 murine carcinoma, CD44-Doxil groups exhibited significantly higher doxorubicin concentration (than Doxil) inside the tumor cells, while their circulation time and distribution profile remained comparable. liposomal doxorubicin 127-132 CD44 antigen Mus musculus 46-50 26518722-7 2015 CD44-Doxil at doses of either 10 or 15 mg/kg resulted in superior tumor growth inhibition and higher inclination to tumor, indicating the potential of anti-CD44 mAb targeting in therapeutic efficacy improvement. liposomal doxorubicin 5-10 CD44 antigen Mus musculus 0-4 26518722-7 2015 CD44-Doxil at doses of either 10 or 15 mg/kg resulted in superior tumor growth inhibition and higher inclination to tumor, indicating the potential of anti-CD44 mAb targeting in therapeutic efficacy improvement. liposomal doxorubicin 5-10 CD44 antigen Mus musculus 156-160