PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30145367-6	2018	The stimulatory effect of NK1R inhibition on ATO cytotoxicity is probably mediated through up-regulation of p73, which can subsequently engage p21 and NF-kappaB pathway via transcriptional suppression of c-Myc.	ato	45-48	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	204-209	
28901456-5	2017	In this study, ATO was shown to promote apoptosis and to inhibit cell viability in MCL cell lines, whereas, the expression of DNA methyltransferase-1 (DNMT-1), beta-catenin and the downstream molecules of Wnt/beta-catenin pathway such as c-myc, cyclin D1 and MMP7 were all decreased in a dose-dependent manner with ATO.	ato	15-18	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	238-243	
28533173-4	2017	The resulting data delineated that short-term treatment of the cells with hTR ASODN either as single agent or in combination with ATO resulted in apoptotic cell death through activation of DNA damage response via up-regulation of p73 and ATM coupled with down-regulation of c-Myc.	ato	130-133	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	274-279	
24161621-5	2013	Moreover, expressions of c-Myc, Bad, Bax and ATM in SK-N-BE(2) cell line were significantly increased by U0126+ATO treatment as compared to treatment with ATO alone.	ato	111-114	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	25-30	
24161621-5	2013	Moreover, expressions of c-Myc, Bad, Bax and ATM in SK-N-BE(2) cell line were significantly increased by U0126+ATO treatment as compared to treatment with ATO alone.	ato	155-158	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	25-30	
32553459-2	2020	Herein, we aimed to investigate whether c-Myc inhibition could reinforce the anti-leukemic effect of ATO, while reducing its concentration in APL cells.	ato	101-104	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	40-45	
32553459-6	2020	Moreover, the combination of 10058-F4 and ATO abrogated the activation of the PI3K pathway, while neither agent had significant suppressive impact on this pathway; suggesting for the first time that probably the companionship of c-Myc inhibitor may be an appealing strategy for shifting the resistance condition toward a chemo-sensitive phenotype, without the necessity to elevate the effective dose of ATO.	ato	42-45	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	229-234	
32553459-6	2020	Moreover, the combination of 10058-F4 and ATO abrogated the activation of the PI3K pathway, while neither agent had significant suppressive impact on this pathway; suggesting for the first time that probably the companionship of c-Myc inhibitor may be an appealing strategy for shifting the resistance condition toward a chemo-sensitive phenotype, without the necessity to elevate the effective dose of ATO.	ato	403-406	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	229-234