PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33074129-0 2021 Rova-T enhances the anti-tumor activity of anti-PD1 in a murine model of small cell lung cancer with endogenous Dll3 expression. rovalpituzumab tesirine 0-6 programmed cell death 1 Mus musculus 48-51 33074129-3 2021 Using a pre-clinical murine SCLC tumor model that expresses Dll3 and has an intact murine immune system, we found that sub-efficacious doses of Rova-T with anti-PD1 resulted in enhanced anti-tumor activity, compared to either monotherapy. rovalpituzumab tesirine 144-150 programmed cell death 1 Mus musculus 161-164 33074129-7 2021 Whole transcriptome analysis as well as flow cytometry and IHC showed that Rova-T activates dendritic cells and increases Ccl5, Il-12, and Icam more than anti-PD1 alone. rovalpituzumab tesirine 75-81 programmed cell death 1 Mus musculus 159-162 33074129-8 2021 Increased tumor expression of PDL1 and MHC1 following Rova-T treatment also supports combination with anti-PD1. rovalpituzumab tesirine 54-60 programmed cell death 1 Mus musculus 107-110