PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21123042-1	2011	This paper describes the preparation of a biomimetic Langmuir-Blodgett film of tyrosinase incorporated in a lipidic layer and the use of lutetium bisphthalocyanine as an electron mediator for the voltammetric detection of phenol derivatives, which include one monophenol (vanillic acid), two diphenols (catechol and caffeic acid) and two triphenols (gallic acid and pyrogallol).	caffeic acid	316-328	tyrosinase	Homo sapiens	79-89	
21458432-11	2011	Caffeic acid, a hydrolyzed product of CAPE, showed a similar GST inhibition in the presence of tyrosinase.	caffeic acid	0-12	tyrosinase	Homo sapiens	95-105	
21458432-13	2011	In conclusion, both CAPE and caffeic acid selectively inhibited GST in the presence of tyrosinase.	caffeic acid	29-41	tyrosinase	Homo sapiens	87-97	
16325827-1	2006	The products of tyrosinase-catalyzed caffeic acid oxidation at pH 6.5 were investigated using high-performance liquid chromatography (HPLC) coupled to electrospray ionization mass spectrometry (ESI-MS).	caffeic acid	37-49	tyrosinase	Homo sapiens	16-26	
17716620-2	2007	In the present study, we show that the polyphenols, (+)-catechin and caffeic acid, which contain a catechol moiety, inhibit tyrosinase-induced formation of 5-S-cysteinyl-dopamine via their capacity to undergo tyrosinase-induced oxidation to yield cysteinyl-polyphenol adducts.	caffeic acid	69-81	tyrosinase	Homo sapiens	124-134	
17716620-2	2007	In the present study, we show that the polyphenols, (+)-catechin and caffeic acid, which contain a catechol moiety, inhibit tyrosinase-induced formation of 5-S-cysteinyl-dopamine via their capacity to undergo tyrosinase-induced oxidation to yield cysteinyl-polyphenol adducts.	caffeic acid	69-81	tyrosinase	Homo sapiens	209-219	
30042336-1	2018	Caffeic acid derivatives represent promising lead compounds in the search for tyrosinase inhibitors to be used in the treatment of skin local hyperpigmentation associated to an overproduction or accumulation of melanin.	caffeic acid	0-12	tyrosinase	Homo sapiens	78-88	
32625101-5	2020	In addition, coumaric acid- and caffeic acid-conjugated peptides suppressed tyrosinase activity more than arbutin, a known tyrosinase inhibitor.	caffeic acid	32-44	tyrosinase	Homo sapiens	76-86	
32625101-5	2020	In addition, coumaric acid- and caffeic acid-conjugated peptides suppressed tyrosinase activity more than arbutin, a known tyrosinase inhibitor.	caffeic acid	32-44	tyrosinase	Homo sapiens	123-133	
32337685-8	2020	Kinetic data showed that tyrosinase had the greatest substrate affnity to chlorogenic acid compared with its isomers and caffeic acid.	caffeic acid	121-133	tyrosinase	Homo sapiens	25-35	
30063931-3	2018	However, 3-hydroxycinnamic, 4-hydroxycinnamic and 3,4-dihydroxycinnamic acids were seen to be substrates of tyrosinase at the same time.	caffeic acid	50-77	tyrosinase	Homo sapiens	108-118	
30042336-2	2018	We recently reported the marked inhibitory activity of a conjugate of caffeic acid with dihydrolipoic acid, 2-S-lipoylcaffeic acid (LCA), on the tyrosine hydroxylase (TH) and dopa oxidase (DO) activities of mushroom tyrosinase.	caffeic acid	70-82	tyrosinase	Homo sapiens	216-226	
28388092-5	2017	The kcat value of tyrosinase obtained for caffeic acid was higher than that obtained for p-coumaric acid, while the affinity was higher for p-coumaric acid.	caffeic acid	42-54	tyrosinase	Homo sapiens	18-28	
29080822-0	2018	Action of tyrosinase on caffeic acid and its n-nonyl ester.	caffeic acid	24-36	tyrosinase	Homo sapiens	10-20	
29080822-3	2018	The action of tyrosinase on caffeic acid and its n-nonyl ester (n-nonyl caffeate) was characterized kinetically in this work.	caffeic acid	28-40	tyrosinase	Homo sapiens	14-24	
28012343-3	2017	To this purpose, we evaluated the capability of tyrosinase to oxidize a natural o-diphenol substrate to o-quinone analyzing the changes in the UV-Vis spectrum of a solution of caffeic acid and the reduction of the cathodic current in a tyrosinase-biosensor, respectively.	caffeic acid	176-188	tyrosinase	Homo sapiens	48-58