PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18485152-5	2008	Furthermore, AG490 and AG1478, JAK2 inhibitor and EGFR inhibitor, respectively, prevented the IL-6- and EGF-induced proliferation of the cells.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	13-18	interleukin 6	Mus musculus	94-98	
18656556-8	2008	The injection of zymosan resulted in a substantial increase in the serum level of TNF-alpha and IL-6, which was strongly inhibited by AG-490.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	134-140	interleukin 6	Mus musculus	96-100	
19416544-15	2009	These beneficial effects of AG-490 were related to lowered levels of circulating IL-6, MIP-1alpha and C5a, and to inhibited expression of STAT1, STAT3 and C5aR in kidneys.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	28-34	interleukin 6	Mus musculus	81-85	
34821076-8	2022	Mice lacking Il6st, encoding gp130, in myocytes (cKO) and WT controls, as well as mice treated with the JAK2 inhibitor AG490 or vehicle were exposed to CLP or sham surgery for 24 or 96 h. RESULTS: Analyses of differentially expressed genes in RNAseq (>=2-log2-fold change, P < 0.01) revealed an activation of IL-6-signalling and JAK/STAT-signalling pathways in muscle of septic mice, which occurred after 24 h and lasted at least for 96 h during sepsis.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	119-124	interleukin 6	Mus musculus	309-313	
33004756-11	2020	AG490, an IL-6 inhibitor, inhibited the occurrence of EMT.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	0-5	interleukin 6	Mus musculus	10-14	
29751177-8	2018	Furthermore, treatment with AG-490, an inhibitor of JAK family kinases, suppressed activation of the IL-6/JAK2/STAT3 signaling cascade, in turn resulting in a decreased number of plasma cells in the mammary gland and reversing the pathogenesis of PCM.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	28-34	interleukin 6	Mus musculus	101-105	
30643061-9	2018	Intrathecal injection of AG-490 can reduce the BCP, and inhibit the activation of IL-6-JAK2 signaling pathway, which may be one of the mechanisms for spinal astrocyte activation.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	25-31	interleukin 6	Mus musculus	82-86	
30403186-10	2018	By blocking this pathway with an antagonist, AG490, the expression of TNF-alpha, IL-1beta, and IL-6 was alleviated.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	45-50	interleukin 6	Mus musculus	95-99	
22969062-6	2012	Inhibition of JAK (STAT1/STAT5 kinase) with AG490 markedly reduced the production of IL-6 and TNF-alpha in macrophages.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	44-49	interleukin 6	Mus musculus	85-89	
23499905-6	2013	Inhibition of JAK2 with AG490 or inhibition of cholinergic signaling with the M1 mAChR antagonist dicyclomine counteracted the attenuating effects of rIL-6 on phosphorylated extracellular signal-regulated kinase (ERK) expression, or on cognitive impairment in TMT-treated IL-6(-/-) mice.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	24-29	interleukin 6	Mus musculus	151-155	
19327909-10	2009	IL-6 plus RT-induced HBV DNA replication in HepG2.2.15 cells was suppressed by the STAT3 inhibitor AG490 and by transfection with dominant-negative STAT3 plasmid.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	99-104	interleukin 6	Mus musculus	0-4