PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24856768-3	2014	Furthermore, tetrandrine and fangchinoline increased the intracellular accumulation of the fluorescent P-glycoprotein (P-gp) substrate rhodamine 123 (Rho123) and inhibited its efflux in Caco-2 and CEM/ADR5000 cells.	fangchinoline	29-42	ATP binding cassette subfamily B member 1	Homo sapiens	119-123	
24856768-0	2014	Tetrandrine and fangchinoline, bisbenzylisoquinoline alkaloids from Stephania tetrandra can reverse multidrug resistance by inhibiting P-glycoprotein activity in multidrug resistant human cancer cells.	fangchinoline	16-29	ATP binding cassette subfamily B member 1	Homo sapiens	135-149	
24856768-3	2014	Furthermore, tetrandrine and fangchinoline increased the intracellular accumulation of the fluorescent P-glycoprotein (P-gp) substrate rhodamine 123 (Rho123) and inhibited its efflux in Caco-2 and CEM/ADR5000 cells.	fangchinoline	29-42	ATP binding cassette subfamily B member 1	Homo sapiens	103-117	
24856768-4	2014	In addition, tetrandrine and fangchinoline significantly reduced P-gp expression in a concentration-dependent manner.	fangchinoline	29-42	ATP binding cassette subfamily B member 1	Homo sapiens	65-69	
24856768-5	2014	These results suggest that tetrandrine and fangchinoline can reverse MDR by increasing the intracellular concentration of anticancer drugs, and thus they could serve as a lead for developing new drugs to overcome P-gp mediated drug resistance in clinic cancer therapy.	fangchinoline	43-56	ATP binding cassette subfamily B member 1	Homo sapiens	213-217	
20822025-0	2010	[Transmembrane transport activity of paclitaxel regulated by fangchinoline in MDR1-mDCK II cells].	fangchinoline	61-74	ATP binding cassette subfamily B member 1	Homo sapiens	78-82	
20822025-1	2010	OBJECTIVE: To research the regulation of transmembrane transport activity of paclitaxel influenced by fangchinoline in MDR1-MDCK II cells.	fangchinoline	102-115	ATP binding cassette subfamily B member 1	Homo sapiens	119-123	
20822025-3	2010	Verapamil hydrochloride was adopted as the active control to investigate the bilateral transport activity of paclitaxel regulated by fangchinoline in MDR1-MDCK II cells.	fangchinoline	133-146	ATP binding cassette subfamily B member 1	Homo sapiens	150-154	
9625436-0	1998	The bisbenzylisoquinoline alkaloids, tetrandine and fangchinoline, enhance the cytotoxicity of multidrug resistance-related drugs via modulation of P-glycoprotein.	fangchinoline	52-65	ATP binding cassette subfamily B member 1	Homo sapiens	148-162