PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18567745-0	2008	Enterolactone induces heme oxygenase-1 expression through nuclear factor-E2-related factor 2 activation in endothelial cells.	2,3-bis(3'-hydroxybenzyl)butyrolactone	0-13	heme oxygenase 1	Homo sapiens	22-38	
18567745-4	2008	Our aim was therefore to assess whether enterolactone has indirect antioxidative effects via induction of HO-1 in endothelial cells.	2,3-bis(3'-hydroxybenzyl)butyrolactone	40-53	heme oxygenase 1	Homo sapiens	106-110	
18567745-5	2008	The effect of enterolactone on HO-1 mRNA and protein expression in human umbilical vein endothelial cells (HUVEC) was analyzed by quantitative real-time PCR and western blot.	2,3-bis(3'-hydroxybenzyl)butyrolactone	14-27	heme oxygenase 1	Homo sapiens	31-35	
18567745-6	2008	The role of nuclear factor-E2-related factor 2 (Nrf2) in HO-1 induction by enterolactone was studied using small interfering RNA (siRNA) and chromatin immunoprecipitation (ChIP) methods.	2,3-bis(3'-hydroxybenzyl)butyrolactone	75-88	heme oxygenase 1	Homo sapiens	57-61	
18567745-7	2008	Our results showed that enterolactone induced HO-1 in HUVEC in a time- and concentration-dependent manner.	2,3-bis(3'-hydroxybenzyl)butyrolactone	24-37	heme oxygenase 1	Homo sapiens	46-50	
18567745-8	2008	The induction appeared to be mediated via the transcription factor Nrf2, as Nrf2 siRNA abolished the HO-1 induction by enterolactone.	2,3-bis(3'-hydroxybenzyl)butyrolactone	119-132	heme oxygenase 1	Homo sapiens	101-105	
18567745-9	2008	We also showed using ChIP that exposure to enterolactone increased the binding of Nrf2 to the promoter region of HO-1.	2,3-bis(3'-hydroxybenzyl)butyrolactone	43-56	heme oxygenase 1	Homo sapiens	113-117	
18567745-10	2008	In conclusion, enterolactone increases the expression of HO-1 via Nrf2, which may contribute to its vasculoprotective effects.	2,3-bis(3'-hydroxybenzyl)butyrolactone	15-28	heme oxygenase 1	Homo sapiens	57-61