PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14561820-2 2003 Here we show that the two types of lipid act by the same mechanism: oleoyl-CoA potently reduced the ATP sensitivity of cardiac (Kir6.2/SUR2A) and pancreatic (Kir6.2/SUR1) KATP channels in a way very similar to PIP2. oleoyl-coenzyme A 68-78 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 128-134 14561820-2 2003 Here we show that the two types of lipid act by the same mechanism: oleoyl-CoA potently reduced the ATP sensitivity of cardiac (Kir6.2/SUR2A) and pancreatic (Kir6.2/SUR1) KATP channels in a way very similar to PIP2. oleoyl-coenzyme A 68-78 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 158-164 14561820-3 2003 Mutations (R54Q, R176A) in the C- and N-terminus of Kir6.2 that greatly reduced the PIP2 modulation of ATP sensitivity likewise reduced the modulation by oleoyl-CoA, indicating that the two lipids interact with the same site. oleoyl-coenzyme A 154-164 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 52-58