PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33348310-0	2021	Diacerein protects rats with liver ischemia/reperfusion damage: Down-regulation of TLR4/ NFkappa-B signaling pathway.	diacerein	0-9	toll-like receptor 4	Rattus norvegicus	83-87	
33348310-8	2021	RESULTS: Diacerein pretreatment has the ability to restore the hepatic I/R damaging effect, proved by the reduction of serum liver enzymes, the decrease of the oxidative stress and hepatic inflammation via down-regulation of TLR4/ NFkappa-B signaling pathway together with the restoration of L-FABP level and improvement of the histopathological and immunohistochemical study findings in the hepatic tissue.	diacerein	9-18	toll-like receptor 4	Rattus norvegicus	225-229	
33348310-9	2021	CONCLUSION: These results suggested the hepatoprotective effect of diacerein relies on its antioxidant and anti-inflammatory effects reducing TLR4/ NFkappa-B signaling pathway.	diacerein	67-76	toll-like receptor 4	Rattus norvegicus	142-146	
35366176-0	2022	Diacerein ameliorates acetaminophen hepatotoxicity in rats via inhibiting HMGB1/TLR4/NF-kappaB and upregulating PPAR-gamma signal.	diacerein	0-9	toll-like receptor 4	Rattus norvegicus	80-84	
35366176-5	2022	Hence, this study attempted to evaluate the impact of DIA treatment on liver injury induced by APAP and its influence on nuclear factor-kappaB (NF-kappaB) /toll-like receptor 4 (TLR4)/high mobility group box-1(HMGB-1) signaling as well as the expression of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) expression.	diacerein	54-57	toll-like receptor 4	Rattus norvegicus	156-176	
35366176-5	2022	Hence, this study attempted to evaluate the impact of DIA treatment on liver injury induced by APAP and its influence on nuclear factor-kappaB (NF-kappaB) /toll-like receptor 4 (TLR4)/high mobility group box-1(HMGB-1) signaling as well as the expression of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) expression.	diacerein	54-57	toll-like receptor 4	Rattus norvegicus	178-182	
35366176-13	2022	CONCLUSIONS: This study demonstrated that DIA exerts anti-apoptotic, anti-inflammatory, and antioxidant properties against liver injury induced by APAP that is attributed to inhibition of the HMGB1/TLR4/NF-kappaB pathway, besides upregulation of the expression of PPAR-gamma.	diacerein	42-45	toll-like receptor 4	Rattus norvegicus	198-202