PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35196878-5	2022	Diacerein treatment mitigated the cartilage damage and significantly inhibited the DNMT1/3a upregulations, the PPARgamma promoter hypermethylation and the PPARgamma loss, and effectively corrected the adverse expression of antioxidant enzymes and inflammatory cytokines.	diacerein	0-9	DNA methyltransferase (cytosine-5) 1	Mus musculus	83-91	
35196878-6	2022	In cultured chondrocytes, diacerein reduced the IL-1beta-induced PPARgamma suppression and the abnormal expression of its downstream antioxidant enzymes in a gain of DNMT and PPARgamma inhibition-sensitive manner, and in PPARgamma knockout mice, the anti-OA effects of diacerein were significantly reduced.	diacerein	26-35	DNA methyltransferase (cytosine-5) 1	Mus musculus	166-170	
35196878-7	2022	INNOVATION: Our work reveals a novel anti-OA pharmacological property of diacerein, and identifies the aberrant DNMT elevations and the resultant PPARgamma suppression as an important epigenetic pathway that mediates diacerein"s anti-OA activities.	diacerein	73-82	DNA methyltransferase (cytosine-5) 1	Mus musculus	112-116