PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25521189-0	2015	The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells.	Dexrazoxane	41-52	activating transcription factor 3	Homo sapiens	73-77	
25521189-2	2015	EXPERIMENTAL APPROACH: We investigated the DNA damage response and the role of the activating transcription factor 3 (ATF3) accumulation in tumour cells exposed to dexrazoxane.	Dexrazoxane	164-175	activating transcription factor 3	Homo sapiens	83-116	
25521189-2	2015	EXPERIMENTAL APPROACH: We investigated the DNA damage response and the role of the activating transcription factor 3 (ATF3) accumulation in tumour cells exposed to dexrazoxane.	Dexrazoxane	164-175	activating transcription factor 3	Homo sapiens	118-122	
25521189-6	2015	ATF3 protein was induced by dexrazoxane in a concentration- and time-dependent manner, which was abolished in TOP2A-depleted cells and in cells pre-incubated with ATM inhibitor.	Dexrazoxane	28-39	activating transcription factor 3	Homo sapiens	0-4	
25521189-7	2015	Knockdown of ATF3 gene expression by siRNA triggered apoptosis in control cells and diminished the p53 protein level in both control and dexrazoxane -treated cells.	Dexrazoxane	137-148	activating transcription factor 3	Homo sapiens	13-17	
25521189-9	2015	ATF3 knockdown also delayed the repair of dexrazoxane -induced DNA double-strand breaks.	Dexrazoxane	42-53	activating transcription factor 3	Homo sapiens	0-4	
25521189-11	2015	The DNA damage-triggered ATF3 controlled p53 accumulation and generation of double-strand breaks and is proposed to serve as a switch between DNA damage and cell death following dexrazoxane treatment.	Dexrazoxane	178-189	activating transcription factor 3	Homo sapiens	25-29