PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25762088-3 2015 RESULTS: Tizoxanide, the primary active metabolite of the FDA approved drug nitazoxanide, fit in silico pharmacophore models constructed for both mGluR1 and mGluR5. tizoxanide 9-19 glutamate receptor, ionotropic, kainate 1 Mus musculus 157-163 25762088-4 2015 Subsequent calcium (Ca++) mobilization functional assays confirmed that tizoxanide exhibited appreciable antagonist activity for both mGluR1 and mGluR5 (IC50 = 1.8 muM and 1.2 muM, respectively). tizoxanide 72-82 glutamate receptor, ionotropic, kainate 1 Mus musculus 145-151