PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23836902-3 2013 These are increased amounts of POR, the allosteric action of cytochrome b5 to promote POR-P450c17 interaction, and Ser/Thr phosphorylation of P450c17, which also appears to promote POR-P450c17 interaction. Serine 115-118 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 142-149 25224484-5 2015 Third, the serine/threonine phosphorylation of P450c17 itself promotes 17,20 lyase activity, again apparently by promoting the interaction of P450c17 with POR. Serine 11-17 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 47-54 25224484-5 2015 Third, the serine/threonine phosphorylation of P450c17 itself promotes 17,20 lyase activity, again apparently by promoting the interaction of P450c17 with POR. Serine 11-17 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 142-149 23836902-3 2013 These are increased amounts of POR, the allosteric action of cytochrome b5 to promote POR-P450c17 interaction, and Ser/Thr phosphorylation of P450c17, which also appears to promote POR-P450c17 interaction. Serine 115-118 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 142-149 20160131-0 2010 Human cytochrome p450c17: single step purification and phosphorylation of serine 258 by protein kinase a. Serine 74-80 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 6-24 20534731-9 2010 Although starvation increased serine phosphorylation of P450c17 specifically, cAMP stimulation enhanced threonine phosphorylation exclusively. Serine 30-36 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 56-63 20160131-4 2010 One factor favoring more efficient electron transfer and 17,20 lyase activity is cAMP-dependent serine/threonine phosphorylation of P450c17. Serine 96-102 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 132-139 20160131-8 2010 Using this vector, we explored P450c17 phosphorylation by mutagenesis of Ser and/or Thr residues to Asp or Glu to mimic the approximate size and charge of phospho-Ser or phospho-Thr. Serine 73-76 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 31-38 16350721-12 2005 Serine phosphorylation is also involved in the postranslational regulation of 17,20-lyase activity (CYP17). Serine 0-6 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 100-105 18821018-9 2009 The discrimination between 17alpha-hydroxylase and 17,20 lyase activities is regulated by two post-translational events, the serine phosphorylation of P450c17 and the allosteric action of cytochrome b5, both of which act to optimize the interaction of P450c17 with its obligatory electron donor, P450 oxidoreductase. Serine 125-131 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 151-158 18821018-9 2009 The discrimination between 17alpha-hydroxylase and 17,20 lyase activities is regulated by two post-translational events, the serine phosphorylation of P450c17 and the allosteric action of cytochrome b5, both of which act to optimize the interaction of P450c17 with its obligatory electron donor, P450 oxidoreductase. Serine 125-131 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 252-259 18187541-3 2008 Serine phosphorylation of P450c17 increases 17,20 lyase activity by increasing the enzyme"s affinity for its redox partner, P450 oxidoreductase. Serine 0-6 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 26-33 16616104-0 2006 Mutagenesis of putative serine-threonine phosphorylation sites proximal to Arg255 of human cytochrome P450c17 does not selectively promote its 17,20-lyase activity. Serine 24-30 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 91-109 16616104-1 2006 OBJECTIVE: To investigate the role of serine-threonine phosphorylation on the activity of human P450c17. Serine 38-44 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 96-103 18493130-10 2008 The discrimination between 17alpha-hydroxylase and 17,20 lyase activities is regulated by two posttranslational events, the serine phosphorylation of P450c17 and the allosteric action of cytochrome b5, both of which act to optimize the interaction of P450c17 with its obligatory electron donor, P450 oxidoreductase. Serine 124-130 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 150-157 18493130-10 2008 The discrimination between 17alpha-hydroxylase and 17,20 lyase activities is regulated by two posttranslational events, the serine phosphorylation of P450c17 and the allosteric action of cytochrome b5, both of which act to optimize the interaction of P450c17 with its obligatory electron donor, P450 oxidoreductase. Serine 124-130 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 251-258 16103714-10 2005 This ratio is regulated posttranslationally by at least three factors: the abundance of the electron-donating protein P450 oxidoreductase (POR), the presence of cytochrome b5 and the serine phosphorylation of P450c17. Serine 183-189 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 209-216 15687493-0 2005 Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17. Serine 59-65 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 85-92 15687493-3 2005 We have shown that serine phosphorylation of P450c17 and the allosteric action of cytochrome b5 increase 17,20 lyase activity, but it has not been apparent whether these two post-translational mechanisms interact. Serine 19-25 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 45-52 12706306-6 2003 The other allele contained nine-base pair deletion, located in exon 8, eliminating codons 487-489 (Asp-Ser-Phe) near the carboxy-terminus of P450c17. Serine 103-106 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 141-148 12444089-2 2003 Serine phosphorylation of P450c17 specifically increases 17,20 lyase activity, but the physiological factors regulating this effect remain unknown. Serine 0-6 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 26-33 9408743-6 1997 Serine phosphorylation appears to modulate the activity of the key regulatory enzyme of androgen biosynthesis, P450c17. Serine 0-6 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 111-118 10626547-8 1999 P450c17 appears to catalyze 17,20-lyase activity only if P450c17 has undergone serine phosphorylation and has access to cytochrome b5 as an allosteric cofactor. Serine 79-85 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 10626547-8 1999 P450c17 appears to catalyze 17,20-lyase activity only if P450c17 has undergone serine phosphorylation and has access to cytochrome b5 as an allosteric cofactor. Serine 79-85 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 57-64 10626547-11 1999 Mechanistic considerations of PCOS suggest a key role for serine phosphorylation of P450c17 in both adrenarche and some forms of heritable PCOS. Serine 58-64 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 84-91 12573809-8 2002 This ratio is regulated post-translationally by at least three factors: the abundance of the electron-donating protein P450 oxidoreductase, the presence of cytochrome b(5), and the serine phosphorylation of P450c17. Serine 181-187 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 207-214 11095477-4 2000 Previous studies have shown that serine hyperphosphorylation of P450c17 increases the enzyme"s 17,20-lyase activity, thereby favoring androgen production, and that serine phosphorylation of the insulin receptor beta-chain (IR-beta) inhibits IR-beta tyrosine phosphorylation, causing insulin resistance in vitro. Serine 33-39 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 64-71 9922107-11 1998 An integrating link between insulin resistance and hyperandrogenemia may be serine phosphorylation, which inhibits activity of the insulin receptor and promotes the 17,20-lyase activity of P450c17. Serine 76-82 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 189-196 18406239-4 1998 Lyase activity and androgen synthesis are particularly dependent on the serine phosphorylation of P450c17. Serine 72-78 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 98-105 9029728-9 1997 We have recently shown that P450c17 must be phosphorylated on serine and threonine residues by a cAMP-dependent protein kinase to acquire 17,20 lyase activity. Serine 62-68 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 28-35 9029728-14 1997 Alternatively, the affinity of P450c17 for redox partners may be selectively increased by Ser/Thr phosphorylation, or selectively decreased by certain mutations in the redox partner binding site, in either case altering an electrostatic interaction between P450c17 and the redox partner. Serine 90-93 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 31-38 7479852-0 1995 Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome. Serine 0-6 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 32-39 7479852-3 1995 We show that human P450c17 is phosphorylated on serine and threonine residues by a cAMP-dependent protein kinase. Serine 48-54 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 19-26 7479852-5 1995 Hormonally regulated serine phosphorylation of human P450c17 suggests a possible mechanism for human adrenarche and may be a unifying etiologic link between the hyperandrogenism and insulin resistance that characterize the polycystic ovary syndrome. Serine 21-27 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 53-60 8345056-4 1993 Analysis of her P450c17 gene by polymerase chain reaction amplification and sequencing showed a nine-base deletion, eliminating codons 487-489 (Asp-Ser-Phe) near the carboxy-terminus of P450c17. Serine 148-151 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 16-23 8504753-7 1993 Ser is found at position 106 in P450c17 in all mammals and birds studied, but the corresponding residue (position 112) in fish (trout) is Thr. Serine 0-3 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 32-39