PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34323489-3 2022 A tertiary cystein 797 to serine 797 (C797S) mutation in the EGFR kinase domain has hampered Osimertinib treatment in patients with advanced EGFR-mutated non-small-cell lung cancer (NSCLC). Serine 26-32 epidermal growth factor receptor Homo sapiens 61-65 34323489-3 2022 A tertiary cystein 797 to serine 797 (C797S) mutation in the EGFR kinase domain has hampered Osimertinib treatment in patients with advanced EGFR-mutated non-small-cell lung cancer (NSCLC). Serine 26-32 epidermal growth factor receptor Homo sapiens 141-145 35093568-2 2022 On the other hand, cellular stress triggers the non-canonical CME of ligand-free EGFR monomers via the phosphorylation of serine/threonine residues by p38. Serine 122-128 epidermal growth factor receptor Homo sapiens 81-85 3138233-13 1988 Regulated phosphorylation of the EGF receptor at these threonine and serine residues may influence aspects of receptor function. Serine 69-75 epidermal growth factor receptor Homo sapiens 33-45 2477372-11 1989 The homologous sequence in the chicken EGF receptor, which binds mouse EGF with a 100-fold lower affinity than the human EGF receptor, contains four amino acid differences including two in the Arg-Gly-Asp-Ser tetramer. Serine 205-208 epidermal growth factor receptor Homo sapiens 39-51 2477372-11 1989 The homologous sequence in the chicken EGF receptor, which binds mouse EGF with a 100-fold lower affinity than the human EGF receptor, contains four amino acid differences including two in the Arg-Gly-Asp-Ser tetramer. Serine 205-208 epidermal growth factor receptor Homo sapiens 121-133 3202876-3 1988 However, thapsigargin does stimulate phosphorylation of the EGF receptor at other serine and threonine residues. Serine 82-88 epidermal growth factor receptor Homo sapiens 60-72 2482148-5 1989 Using the conjugate Pam3 Cys-Ser-EGFR(516-529), a peptide-specific monoclonal antibody was produced. Serine 29-32 epidermal growth factor receptor Homo sapiens 33-37 2982824-6 1985 Immunoprecipitation of the EGF receptor from A431 cells labeled for 24 h with [32P]phosphate demonstrated that amiloride decreased the phosphorylation of the EGF receptor on serine and threonine residues and blocked the effect of EGF to cause phosphorylation of the receptor on tyrosine residues. Serine 174-180 epidermal growth factor receptor Homo sapiens 158-170 6092336-5 1984 OADG, like TPA, caused loss of binding to an apparent high affinity class of receptors, blocked EGF-induced tyrosine phosphorylation of the EGF receptor, and stimulated phosphorylation of the EGF receptor at both serine and threonine residues. Serine 213-219 epidermal growth factor receptor Homo sapiens 192-204 6321473-3 1984 Phosphorylation of the EGF receptor is Ca2+-dependent and occurs at threonine and serine residues. Serine 82-88 epidermal growth factor receptor Homo sapiens 23-35 33737524-6 2021 In comparison to untreated controls, treatment of EJ28Luc cells with 213Bi-anti-EGFR-MAb resulted in a significantly decreased incorporation of 13C from [U-13C6]glucose into alanine, aspartate, glutamate, glycine, proline and serine. Serine 226-232 epidermal growth factor receptor Homo sapiens 80-84 31488827-5 2019 EGFR-activated CDK5 directly binds to and phosphorylates TRIM59, a ubiquitin ligase at serine 308, which recruits PIN1 for cis-trans isomerization of TRIM59, leading to TRIM59 binding to importin alpha5 and nuclear translocation. Serine 87-93 epidermal growth factor receptor Homo sapiens 0-4 33372419-10 2021 Interestingly, p53 and EGFR exon 19 deletion mutations were more frequent in patients with hOGG1 Ser/Cys + Cys/Cys hOGG1-Cys variants than with the hOGG1 Ser/Ser genotype (P = 0.010 for p53, P = 0.032 for EGFR). Serine 97-100 epidermal growth factor receptor Homo sapiens 23-27 32697994-7 2020 We show that oncogenic EGFR(L858R) signaling leads to the phosphorylation of SPRED1 on serine 105, disrupting the SPRED1-neurofibromin complex. Serine 87-93 epidermal growth factor receptor Homo sapiens 23-27 29805654-0 2018 Cisplatin-induced non-canonical endocytosis of EGFR via p38 phosphorylation of the C-terminal region containing Ser-1015 in non-small cell lung cancer cells. Serine 112-115 epidermal growth factor receptor Homo sapiens 47-51 31173177-2 2019 The serine/threonine protein kinase casein kinase II (CK2) phosphorylates and modulates several members of the EGFR downstream signaling pathways. Serine 4-10 epidermal growth factor receptor Homo sapiens 111-115 32923966-2 2019 GPCRs can transactivate protein tyrosine kinase receptors (PTKRs) and serine/threonine kinase receptors (S/TKRs), notably the epidermal growth factor receptor (EGFR) and transforming growth factor-beta type 1 receptor (TGFBR1), respectively. Serine 70-76 epidermal growth factor receptor Homo sapiens 126-158 31221965-5 2019 Specifically, EGFR activation branches glycolysis to the serine synthesis for nucleotide biosynthesis and redox homeostasis, whereas FGFR activation recycles lactate to fuel oxidative phosphorylation for energy generation. Serine 57-63 epidermal growth factor receptor Homo sapiens 14-18 31221965-6 2019 Genetic alterations of EGFR and FGFR stratify the responsive tumors to pharmacological inhibitors that target serine synthesis and lactate fluxes, respectively. Serine 110-116 epidermal growth factor receptor Homo sapiens 23-27 29805654-3 2018 It was recently reported that the phosphorylation of epidermal growth factor receptor (EGFR) at C-terminal Ser-1015 serves a critical role in growth factor and cytokine signaling. Serine 107-110 epidermal growth factor receptor Homo sapiens 53-85 29805654-3 2018 It was recently reported that the phosphorylation of epidermal growth factor receptor (EGFR) at C-terminal Ser-1015 serves a critical role in growth factor and cytokine signaling. Serine 107-110 epidermal growth factor receptor Homo sapiens 87-91 29805654-5 2018 Cisplatin-induced p38 activation triggered the Ser-1015 phosphorylation of EGFR, with similar kinetics to previously reported Ser-1047 phosphorylation, in a tyrosine kinase-independent manner. Serine 47-50 epidermal growth factor receptor Homo sapiens 75-79 29805654-5 2018 Cisplatin-induced p38 activation triggered the Ser-1015 phosphorylation of EGFR, with similar kinetics to previously reported Ser-1047 phosphorylation, in a tyrosine kinase-independent manner. Serine 126-129 epidermal growth factor receptor Homo sapiens 75-79 29805654-6 2018 In addition, phosphorylation around Ser-1015 triggered endocytosis of a dimer deficient mutant of EGFR. Serine 36-39 epidermal growth factor receptor Homo sapiens 98-102 29805654-7 2018 The non-canonical endocytosis of EGFR monomers was primarily controlled by the region around Ser-1015 only; however, Ser-1047 on internalized EGFR was equally phosphorylated. Serine 93-96 epidermal growth factor receptor Homo sapiens 33-37 29805654-7 2018 The non-canonical endocytosis of EGFR monomers was primarily controlled by the region around Ser-1015 only; however, Ser-1047 on internalized EGFR was equally phosphorylated. Serine 117-120 epidermal growth factor receptor Homo sapiens 142-146 28899709-0 2018 Phosphorylation of epidermal growth factor receptor at serine 1047 in cultured lung alveolar epithelial cells by bradykinin B2 receptor stimulation. Serine 55-61 epidermal growth factor receptor Homo sapiens 19-51 29255092-4 2018 Here we demonstrate that a minimal level of activation of epidermal growth factor receptor (EGFR) tyrosine kinase by low levels of ligand is sufficient to fully activate downstream mitogen-activated protein kinase (MAPK) pathways, with most of the remaining unbound EGFR molecules being efficiently phosphorylated at intracellular serine/threonine residues by activated mitogen-activated protein kinase. Serine 331-337 epidermal growth factor receptor Homo sapiens 58-90 29255092-4 2018 Here we demonstrate that a minimal level of activation of epidermal growth factor receptor (EGFR) tyrosine kinase by low levels of ligand is sufficient to fully activate downstream mitogen-activated protein kinase (MAPK) pathways, with most of the remaining unbound EGFR molecules being efficiently phosphorylated at intracellular serine/threonine residues by activated mitogen-activated protein kinase. Serine 331-337 epidermal growth factor receptor Homo sapiens 92-96 29255092-5 2018 This non-canonical, p38-mediated phosphorylation of the C-tail of EGFR, near Ser-1015, induces the clathrin-mediated endocytosis of the unliganded EGFR monomers, which occurs slightly later than the canonical endocytosis of ligand-bound EGFR dimers via tyrosine autophosphorylation. Serine 77-80 epidermal growth factor receptor Homo sapiens 66-70 29255092-5 2018 This non-canonical, p38-mediated phosphorylation of the C-tail of EGFR, near Ser-1015, induces the clathrin-mediated endocytosis of the unliganded EGFR monomers, which occurs slightly later than the canonical endocytosis of ligand-bound EGFR dimers via tyrosine autophosphorylation. Serine 77-80 epidermal growth factor receptor Homo sapiens 147-151 29255092-5 2018 This non-canonical, p38-mediated phosphorylation of the C-tail of EGFR, near Ser-1015, induces the clathrin-mediated endocytosis of the unliganded EGFR monomers, which occurs slightly later than the canonical endocytosis of ligand-bound EGFR dimers via tyrosine autophosphorylation. Serine 77-80 epidermal growth factor receptor Homo sapiens 147-151 29136465-3 2018 However, a high percentage of these treated patients developed a tertiary cystein-797 to serine-790 (C797S) mutation in the EGFR kinase domain. Serine 89-95 epidermal growth factor receptor Homo sapiens 124-128 28899709-1 2018 Accumulating evidence indicates that epidermal growth factor receptor (EGFR) is desensitized by phosphorylation of serine 1047 (Ser1047). Serine 115-121 epidermal growth factor receptor Homo sapiens 37-69 28899709-1 2018 Accumulating evidence indicates that epidermal growth factor receptor (EGFR) is desensitized by phosphorylation of serine 1047 (Ser1047). Serine 115-121 epidermal growth factor receptor Homo sapiens 71-75 29029422-4 2017 Our data shows that activation of the EGFR results in phosphorylation of LysRS at position serine 207, its release from the MSC and translocation to the nucleus. Serine 91-97 epidermal growth factor receptor Homo sapiens 38-42 28486761-8 2017 Panitumumab and the tyrosine kinase inhibitor erlotinib reduced the basal level of EGFR tyrosine phosphorylation and reversed FTD-induced ERK/AKT/STAT3 and EGFR serine/threonine phosphorylation. Serine 161-167 epidermal growth factor receptor Homo sapiens 156-160 27169346-4 2016 The protein kinase activity of PI3K phosphorylates serine residue 70 on Src to enhance its activity and induce EGFR transactivation following betaAR stimulation. Serine 51-57 epidermal growth factor receptor Homo sapiens 111-115 26727965-7 2016 Concerning the positive Sprouty2 effect on epidermal growth factor receptor activation the serine variant is more potent. Serine 91-97 epidermal growth factor receptor Homo sapiens 43-75 22815474-0 2012 Nuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776. Serine 120-126 epidermal growth factor receptor Homo sapiens 8-12 26733497-3 2016 In this study, we found that phosphorylation of a serine residue of EGFR via transforming growth factor beta-activated kinase-1 (TAK1), and subsequent p38alpha activation is essential for H. pylori-induced hBD3 release from gastric epithelial cells. Serine 50-56 epidermal growth factor receptor Homo sapiens 68-72 26733497-5 2016 H. pylori infection induced phosphorylation of serine residue of EGFR, and this phosphorylation was followed by internalization of EGFR; consequently, hBD3 was released at an early phase of the infection. Serine 47-53 epidermal growth factor receptor Homo sapiens 65-69 26751287-2 2016 Here, we identify a cytoplasmic lncRNA, LINK-A (long intergenic non-coding RNA for kinase activation), which mediates HB-EGF-triggered, EGFR:GPNMB heterodimer-dependent HIF1alpha phosphorylation at Tyr 565 and Ser 797 by BRK and LRRK2, respectively. Serine 210-213 epidermal growth factor receptor Homo sapiens 136-140 26211551-9 2015 Moreover, we demonstrated that coupling of the PKCdelta/EGFR/beta-arrestin2 transactivation pathway to delta receptor-mediated ERK1/2 activation was ligand-specific and the Ser(363) of delta receptors was crucial for ligand-specific implementation of this ERK1/2 activation pathway. Serine 173-176 epidermal growth factor receptor Homo sapiens 56-60 26141950-5 2015 Using in vitro studies, we tested the hypothesis that cisplatin and EGFR inhibitors rely on the activation of the tumor suppressor STAT1, characterized by its phosphorylation at serine (S727) or tyrosine (Y701) residues. Serine 178-184 epidermal growth factor receptor Homo sapiens 68-72 26622773-6 2015 In addition, it was revealed that the inhibition of p38 enhanced apoptosis in epidermal growth factor receptor (EGFR)-overexpressing MDA-MB-468 TNBC cells and EGFR-mutant PC-9 non-small-cell lung carcinoma cells, which was associated with the downregulation of EGFR serine phosphorylation. Serine 266-272 epidermal growth factor receptor Homo sapiens 78-110 26622773-6 2015 In addition, it was revealed that the inhibition of p38 enhanced apoptosis in epidermal growth factor receptor (EGFR)-overexpressing MDA-MB-468 TNBC cells and EGFR-mutant PC-9 non-small-cell lung carcinoma cells, which was associated with the downregulation of EGFR serine phosphorylation. Serine 266-272 epidermal growth factor receptor Homo sapiens 112-116 25824408-4 2015 Among several important phosphorylation sites in cytoplasmic EGFR, Rg3 increased the phosphorylation of tyrosine 1045 (pY1045) and serine 1046/1047 (pS1046/1047) for EGFR degradation and coincidently, attenuated pY1173 and pY1068 for mitogen-activated protein kinase activity. Serine 131-137 epidermal growth factor receptor Homo sapiens 61-65 24615012-5 2014 Both Thr(714) and Ser(727) are required for STAT3-dependent gene induction in response to simultaneous activation of epidermal growth factor receptor (EGFR) and protease-activated receptor 1 (PAR-1) in endothelial cells. Serine 18-21 epidermal growth factor receptor Homo sapiens 117-149 24615012-5 2014 Both Thr(714) and Ser(727) are required for STAT3-dependent gene induction in response to simultaneous activation of epidermal growth factor receptor (EGFR) and protease-activated receptor 1 (PAR-1) in endothelial cells. Serine 18-21 epidermal growth factor receptor Homo sapiens 151-155 24553453-7 2014 It has been reported that heterologous desensitization of EGFR is induced by serine phosphorylation of EGFR via the p38 mitogen-activated protein kinase (p38 MAP kinase) pathway in various cell lines, including alveolar epithelial cells. Serine 77-83 epidermal growth factor receptor Homo sapiens 58-62 24553453-7 2014 It has been reported that heterologous desensitization of EGFR is induced by serine phosphorylation of EGFR via the p38 mitogen-activated protein kinase (p38 MAP kinase) pathway in various cell lines, including alveolar epithelial cells. Serine 77-83 epidermal growth factor receptor Homo sapiens 103-107 24240702-2 2013 In this study, we report the identification of a naturally occurring and widely expressed EGFR isoform termed EGFRvA, which substitutes a Ser/Thr-rich peptide for part of the carboxyl-terminal regulatory domain of the receptor. Serine 138-141 epidermal growth factor receptor Homo sapiens 90-94 23822636-1 2013 We have recently identified tumor necrosis factor (TNF)-alpha-induced phosphorylation of epidermal growth factor receptor (EGFR) at Thr-669 and Ser-1046/1047 via ERK and p38 pathways, respectively. Serine 144-147 epidermal growth factor receptor Homo sapiens 123-127 23822636-2 2013 In the present study, we investigated the roles of ligand-induced phosphorylation of serine and threonine residues in EGFR-overexpressing MDA-MB-468 breast cancer cells. Serine 85-91 epidermal growth factor receptor Homo sapiens 118-122 23897813-5 2013 Reduced ubiquitylation of EGFR is accompanied by PKC-dependent increase in serine phosphorylation of c-Cbl in cells expressing elevated levels of CD82. Serine 75-81 epidermal growth factor receptor Homo sapiens 26-30 23178880-2 2012 Here we demonstrate that EGFR-activated ERK2 binds directly to PKM2 Ile 429/Leu 431 through the ERK2 docking groove and phosphorylates PKM2 at Ser 37, but does not phosphorylate PKM1. Serine 143-146 epidermal growth factor receptor Homo sapiens 25-29 23178880-6 2012 In addition, levels of PKM2 Ser 37 phosphorylation correlate with EGFR and ERK1/2 activity in human glioblastoma specimens. Serine 28-31 epidermal growth factor receptor Homo sapiens 66-70 25701783-2 2015 In contrast to the canonical EGFR activation in which tyrosine residues are engaged, we have demonstrated that the non-canonical pathway is triggered by phosphorylation of serine and threonine residues through p38 and ERK MAPKs, respectively. Serine 172-178 epidermal growth factor receptor Homo sapiens 29-33 24091658-0 2013 EGFR/MEK/ERK/CDK5-dependent integrin-independent FAK phosphorylated on serine 732 contributes to microtubule depolymerization and mitosis in tumor cells. Serine 71-77 epidermal growth factor receptor Homo sapiens 0-4 23839800-4 2013 This protein, which behaves similarly to wild-type EGFR with respect to EGF binding, activation, and internalization, can be labeled at a specific serine in the acyl carrier tag with a fluorophore incorporated into a 4"-phosphopantetheine (P-pant) conjugate transferred enzymatically from the corresponding CoA derivative. Serine 147-153 epidermal growth factor receptor Homo sapiens 51-55 23220022-0 2013 Phosphorylation of epidermal growth factor receptor at serine 1047 by MAP kinase-activated protein kinase-2 in cultured lung epithelial cells treated with flagellin. Serine 55-61 epidermal growth factor receptor Homo sapiens 19-51 23220022-1 2013 It has been reported that tumor necrosis factor alpha (TNFalpha) activated the p38 MAP kinase pathway, followed by phosphorylation of epidermal growth factor receptor (EGFR) at serine 1047 (Ser1047). Serine 177-183 epidermal growth factor receptor Homo sapiens 134-166 23220022-1 2013 It has been reported that tumor necrosis factor alpha (TNFalpha) activated the p38 MAP kinase pathway, followed by phosphorylation of epidermal growth factor receptor (EGFR) at serine 1047 (Ser1047). Serine 177-183 epidermal growth factor receptor Homo sapiens 168-172 22464987-2 2012 For this purpose disulfide stabilized scFv domains of the EGFR/ADCC antibody GA201 were fused via serine-glycine connectors to the C-terminus of the heavy (XGFR2) or light chain (XGFR4), or the N-termini of the light (XGFR5) or heavy chain (XGFR3) of the IGF-1R antibody R1507 as parental IgG1 antibody. Serine 98-104 epidermal growth factor receptor Homo sapiens 58-62 21741919-13 2011 DARPP-32-mediated resistance to gefitinib resulted from increased phosphorylation of and interaction between EGFR and ERBB3, which led to phosphorylation of AKT (at serine 473). Serine 165-171 epidermal growth factor receptor Homo sapiens 109-113 20877636-4 2010 Recent reports demonstrated that, under certain types of stimulation, the serine/threonine residues at the pY+1 and/or pY+2 positions within this recognition motif of EGFR and Sprouty2 may be endogenously phosphorylated. Serine 74-80 epidermal growth factor receptor Homo sapiens 167-171 20628053-8 2010 However, Erk-mediated phosphorylation of paxillin on serines 83/126/130 is still needed for both EGFR and PKC-mediated cellular proliferation. Serine 53-60 epidermal growth factor receptor Homo sapiens 97-101 21487020-7 2011 Moreover, nuclear translocation of EGFR requires phosphorylation at Ser-229 by Akt. Serine 68-71 epidermal growth factor receptor Homo sapiens 35-39 21188622-3 2011 We have recently reported that TAK1 regulates phosphorylation of EGFR at Ser-1046/7 through p38 MAPK, which cooperates with NF-kappaB in TNF-alpha-induced apoptosis. Serine 73-76 epidermal growth factor receptor Homo sapiens 65-69 21188622-7 2011 Gomisin N also inhibited p38-mediated phosphorylation of the EGFR at Ser-1046/7 and subsequent endocytosis of EGFR, another prosurvival pathway. Serine 69-72 epidermal growth factor receptor Homo sapiens 61-65 20654626-2 2010 We describe a paratope raised against the human ErbB family member HER2, using a binary diversity tryptophan/serine library displayed on phage. Serine 109-115 epidermal growth factor receptor Homo sapiens 48-52 19531499-3 2009 In response to epidermal growth factor (EGF) stimulation of cells, phosphorylations at EGFR Ser(991) and Tyr(998) accumulated more slowly than at receptor sites involved in RAS-ERK signaling. Serine 92-95 epidermal growth factor receptor Homo sapiens 87-91 19615971-2 2009 Treatment of T84 cells with the selective inhibitor of EGF receptor (EGFR) tyrosine kinase AG1478 abrogated Akt phosphorylation on Ser(473) induced by either carbachol or EGF, indicating that carbachol-induced Akt activation is mediated through EGFR transactivation. Serine 131-134 epidermal growth factor receptor Homo sapiens 55-67 19615971-2 2009 Treatment of T84 cells with the selective inhibitor of EGF receptor (EGFR) tyrosine kinase AG1478 abrogated Akt phosphorylation on Ser(473) induced by either carbachol or EGF, indicating that carbachol-induced Akt activation is mediated through EGFR transactivation. Serine 131-134 epidermal growth factor receptor Homo sapiens 69-73 19578043-8 2009 Taken together, our results strongly suggest that phosphorylation of EGFR at serine 1046/1047 via activation of p38 MAPK plays a pivotal role in EGCG-induced downregulation of EGFR in colon cancer cells. Serine 77-83 epidermal growth factor receptor Homo sapiens 69-73 19578043-8 2009 Taken together, our results strongly suggest that phosphorylation of EGFR at serine 1046/1047 via activation of p38 MAPK plays a pivotal role in EGCG-induced downregulation of EGFR in colon cancer cells. Serine 77-83 epidermal growth factor receptor Homo sapiens 176-180 19531499-13 2009 These results suggest that coordinated phosphorylation of EGFR involving sites Tyr(998), Ser(991), Ser(1039), and Thr(1041) governs the trafficking of EGF receptors. Serine 89-92 epidermal growth factor receptor Homo sapiens 58-62 19531499-13 2009 These results suggest that coordinated phosphorylation of EGFR involving sites Tyr(998), Ser(991), Ser(1039), and Thr(1041) governs the trafficking of EGF receptors. Serine 99-102 epidermal growth factor receptor Homo sapiens 58-62 19531499-8 2009 These residues reside in a serine/threonine-rich region of the receptor previously implicated in p38 mitogen-activated protein kinase-dependent stress/cytokine-induced EGFR internalization and recycling (Zwang, Y., and Yarden, Y. Serine 27-33 epidermal growth factor receptor Homo sapiens 168-172 18054338-4 2008 Prostasin"s role in EGFR cleavage is dependent on the serine active-site but not the GPI-anchor. Serine 54-60 epidermal growth factor receptor Homo sapiens 20-24 18687633-8 2008 These data suggest that a higher proportion of the EGFR mutant carcinoma cells may exhibit activation of the phosphatidylinositol 3-kinase/protein kinase B (AKT)/mammalian target of rapamycin (MTOR) pathway through Tyr-1148 and Tyr-1068 and suppression of IRS-1 Ser-612, altered heterodimerization with ERBB2, reduced response to transforming growth factor beta suppression, and reduced ubiquitination/degradation of the EGFR through EGFR Tyr-1045, thus providing a survival advantage. Serine 262-265 epidermal growth factor receptor Homo sapiens 51-55 19687304-0 2009 TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling. Serine 14-20 epidermal growth factor receptor Homo sapiens 50-82 19386603-6 2009 Both ADAM17 activation and IL-8 release were suppressed by inhibitors of EGFR/ERK1/2 signaling, which can regulate ADAM17 activity by serine/threonine phosphorylation. Serine 134-140 epidermal growth factor receptor Homo sapiens 73-77 18340549-7 2009 Amongst these modification sites, one residue is localized in the juxtamembrane (Thr 654) and two are found in the catalytic domain (Ser 1046/1047) of the EGFR. Serine 133-136 epidermal growth factor receptor Homo sapiens 155-159 18340549-8 2009 We propose that, when EGFR is O-GlcNAc modified on Thr 654, EGFR may be transferred from early to late endosomes, whereas when EGFR is O-GlcNAc modified on Ser 1046/1047 desensitization of the receptor may be prevented. Serine 156-159 epidermal growth factor receptor Homo sapiens 22-26 17720156-7 2007 The mutation at Ser(680) led to enhanced ubiquitin isopeptidase activity of UBPY toward poly-ubiquitin chains and a cellular substrate, epidermal growth factor receptor, in vitro and in vivo. Serine 16-19 epidermal growth factor receptor Homo sapiens 136-168 18354494-4 2008 Here, we show that upon activation of the epidermal growth factor receptor, CtBP1/BARS is (a) translocated to the macropinocytic cup and its surrounding membrane, (b) required for the fission of the macropinocytic cup and (c) phosphorylated on a specific serine that is a substrate for p21-activated kinase, with this phosphorylation being essential for the fission of the macropinocytic cup. Serine 255-261 epidermal growth factor receptor Homo sapiens 42-74 19036157-3 2008 Phosphorylation of YB-1 at the serine 102 residue is required for transcriptional activation of growth-enhancing genes, such as EGFR. Serine 31-37 epidermal growth factor receptor Homo sapiens 128-132 17615294-0 2007 Serine phosphorylation of the integrin beta4 subunit is necessary for epidermal growth factor receptor induced hemidesmosome disruption. Serine 0-6 epidermal growth factor receptor Homo sapiens 70-102 16651443-4 2006 We reasoned that the underlying cause for growth attenuation by YB-1(Ser(102)) is through the regulation of EGFR and/or HER-2. Serine 69-72 epidermal growth factor receptor Homo sapiens 108-112 16932740-6 2006 The underlying mechanism entails phosphorylation of EGFR at a short segment (amino acids 1002-1022) containing multiple serines and threonines, as well as phosphorylation of two Rab5 effectors, EEA1 and GDI. Serine 120-127 epidermal growth factor receptor Homo sapiens 52-56 16651443-13 2006 In conclusion, YB-1(Ser(102)) is a point of molecular vulnerability for maintaining the expression of EGFR and HER-2. Serine 20-23 epidermal growth factor receptor Homo sapiens 102-106 16015604-3 2005 EGFR activates NF-kappaB through the PI3K/Akt pathway that leads to the phosphorylation of IkappaBalpha on serines 32 and 36, thereby promoting the nuclear translocation of the p65 subunit. Serine 107-114 epidermal growth factor receptor Homo sapiens 0-4 16540667-6 2006 In non-small-cell lung cancer cells, STAT3 activity is regulated by EGFR through modulation of STAT3 serine phosphorylation. Serine 101-107 epidermal growth factor receptor Homo sapiens 68-72 16261397-9 2006 These findings suggest that ERalpha function in Tam-R cells is maintained as a consequence of EGFR/MAPK-mediated phosphorylation at serine residue 118 resulting in the generation of a self-propogating autocrine growth-regulatory loop through the ERalpha-mediated production of AR. Serine 132-138 epidermal growth factor receptor Homo sapiens 94-98 15880609-5 2005 EGFR activates NF-kappaB through the phosphorylation of IkappaBalpha on serines 32/36 thereby influencing the nuclear translocation of the p65 subunit. Serine 72-79 epidermal growth factor receptor Homo sapiens 0-4 16226704-4 2005 Serine 112 phosphorylation is EGFR/MEK/MAPK dependent, whereas serine 136 phosphorylation is PI3K/Akt dependent. Serine 0-6 epidermal growth factor receptor Homo sapiens 30-34 16184431-6 2005 This might be an important contributory factor to differences in selectivity of the ligands between the two kinases, probably more so than the conservative change of Cys751 of EGFR to serine in HER-2 at the ATP site. Serine 184-190 epidermal growth factor receptor Homo sapiens 176-180 16113104-2 2005 Our recent in vitro studies also suggest that EGFR signalling productively cross-talks with insulin-like growth factor receptor (IGF-1R) and, where present, activates ER on key AF-1 serine residues to facilitate acquired tamoxifen-resistant growth. Serine 182-188 epidermal growth factor receptor Homo sapiens 46-50 8844333-6 1996 In contrast to v-Src, the activated epidermal growth factor receptor acts indirectly through activated MAP kinase which may stimulate phosphorylation of connexin43 exclusively on serine. Serine 179-185 epidermal growth factor receptor Homo sapiens 36-68 15161351-0 2004 UV-radiation-induced internalization of the epidermal growth factor receptor requires distinct serine and tyrosine residues in the cytoplasmic carboxy-terminal domain. Serine 95-101 epidermal growth factor receptor Homo sapiens 44-76 15161351-4 2004 Mutational removal of serine residues 1046, 1047, 1057 and 1142 within the carboxy-terminal receptor region was also sufficient to abolish UV-radiation-induced internalization of the EGFR. Serine 22-28 epidermal growth factor receptor Homo sapiens 183-187 15161351-7 2004 Our results suggest a mechanism for UV-radiation-induced internalization of EGFR involving a conformational change that is dependent on structural elements formed by specific serine and tyrosine residues in the carboxy-terminal domain. Serine 175-181 epidermal growth factor receptor Homo sapiens 76-80 12354760-7 2002 GM3 also induces delayed serine phosphorylation of EGFR-unassociated caveolin-1, suggesting a role for serine phosphorylation of caveolin-1 in regulating EGFR signaling. Serine 25-31 epidermal growth factor receptor Homo sapiens 51-55 12354760-7 2002 GM3 also induces delayed serine phosphorylation of EGFR-unassociated caveolin-1, suggesting a role for serine phosphorylation of caveolin-1 in regulating EGFR signaling. Serine 103-109 epidermal growth factor receptor Homo sapiens 51-55 12354760-7 2002 GM3 also induces delayed serine phosphorylation of EGFR-unassociated caveolin-1, suggesting a role for serine phosphorylation of caveolin-1 in regulating EGFR signaling. Serine 103-109 epidermal growth factor receptor Homo sapiens 154-158 11330837-1 2001 The carboxyterminal domain of the epidermal growth factor receptor (EGFR)--a putative binding site for the ubiquitin ligase Cbl--is the site of serine phosphorylation events which are essential for ligand-dependent EGFR desensitization and degradation. Serine 144-150 epidermal growth factor receptor Homo sapiens 34-66 11330837-1 2001 The carboxyterminal domain of the epidermal growth factor receptor (EGFR)--a putative binding site for the ubiquitin ligase Cbl--is the site of serine phosphorylation events which are essential for ligand-dependent EGFR desensitization and degradation. Serine 144-150 epidermal growth factor receptor Homo sapiens 68-72 11330837-1 2001 The carboxyterminal domain of the epidermal growth factor receptor (EGFR)--a putative binding site for the ubiquitin ligase Cbl--is the site of serine phosphorylation events which are essential for ligand-dependent EGFR desensitization and degradation. Serine 144-150 epidermal growth factor receptor Homo sapiens 215-219 10601235-4 1999 By using vascular smooth muscle cells in which we have demonstrated Ras/extracellular signal-regulated kinase (ERK) activation through Ca(2+)-dependent, epidermal growth factor (EGF) receptor transactivation by G(q)-coupled angiotensin II (Ang II) receptor, we present a unique cross-talk required for Ser(411) phosphorylation of p70(S6K) by Ang II. Serine 302-305 epidermal growth factor receptor Homo sapiens 153-191 10601235-5 1999 Both p70(S6K) Ser(411) and Akt Ser(473) phosphorylation by Ang II appear to involve EGF receptor transactivation and were inhibited by dominant-negative Ras, whereas the phosphorylation of p70(S6K) and ERK but not Akt was sensitive to the MEK inhibitor. Serine 14-17 epidermal growth factor receptor Homo sapiens 84-96 10601235-5 1999 Both p70(S6K) Ser(411) and Akt Ser(473) phosphorylation by Ang II appear to involve EGF receptor transactivation and were inhibited by dominant-negative Ras, whereas the phosphorylation of p70(S6K) and ERK but not Akt was sensitive to the MEK inhibitor. Serine 31-34 epidermal growth factor receptor Homo sapiens 84-96 10347170-5 1999 Mutation of serines 1046/1047 in full-length EGFR enhanced both fibroblast transformation and tyrosine autokinase activity that was significantly potentiated by additional mutation of serines 1057 and 1142. Serine 12-19 epidermal growth factor receptor Homo sapiens 45-49 10347170-5 1999 Mutation of serines 1046/1047 in full-length EGFR enhanced both fibroblast transformation and tyrosine autokinase activity that was significantly potentiated by additional mutation of serines 1057 and 1142. Serine 184-191 epidermal growth factor receptor Homo sapiens 45-49 11058583-1 2001 We have identified a rapid protein phosphorylation event at residue serine 16 of stathmin using two-dimensional gel electrophoresis coupled to matrix-assisted laser desorption/ionization mass spectrometry in combination with post-source decay analysis, which is induced by the epidermal growth factor receptor. Serine 68-74 epidermal growth factor receptor Homo sapiens 277-309 9346957-4 1997 In contrast, only the non-serine/threonine-phosphorylated fraction of 66-kDa Shc was associated with the EGF receptor. Serine 26-32 epidermal growth factor receptor Homo sapiens 105-117 9346957-9 1997 Together, these data indicate that the serine/threonine phosphorylation of 66-kDa Shc impairs its ability to associate with the tyrosine-phosphorylated EGF receptor and can function in a dominant-interfering manner by inhibiting EGF receptor downstream signaling pathways. Serine 39-45 epidermal growth factor receptor Homo sapiens 152-164 9346957-9 1997 Together, these data indicate that the serine/threonine phosphorylation of 66-kDa Shc impairs its ability to associate with the tyrosine-phosphorylated EGF receptor and can function in a dominant-interfering manner by inhibiting EGF receptor downstream signaling pathways. Serine 39-45 epidermal growth factor receptor Homo sapiens 229-241 7812043-1 1994 We have shown previously that the epidermal growth factor (EGF) receptor is phosphorylated at Ser-1002 and that this phosphorylation is associated with desensitization of the EGF receptor. Serine 94-97 epidermal growth factor receptor Homo sapiens 34-72 8545122-2 1995 One event that occurs rapidly following EGF binding is the covalent modification of the EGF receptor (EGF-R) by phosphorylation on Ser, Thr, and Tyr residues. Serine 131-134 epidermal growth factor receptor Homo sapiens 88-100 8545122-2 1995 One event that occurs rapidly following EGF binding is the covalent modification of the EGF receptor (EGF-R) by phosphorylation on Ser, Thr, and Tyr residues. Serine 131-134 epidermal growth factor receptor Homo sapiens 102-107 7540771-1 1995 The crystal structures of a cysteine-215-->serine mutant of protein tyrosine phosphatase 1B complexed with high-affinity peptide substrates corresponding to an autophosphorylation site of the epidermal growth factor receptor were determined. Serine 46-52 epidermal growth factor receptor Homo sapiens 195-227 7523189-6 1994 Phosphoamino acid analysis demonstrated that the kinase domain of the epidermal growth factor receptor, p56lck and p60c-src phosphorylated myelin basic protein on tyrosines, that the protamine kinase phosphorylated myelin basic protein on serines, and that myelin basic protein kinase-1 phosphorylated myelin basic protein on threonines. Serine 239-246 epidermal growth factor receptor Homo sapiens 70-102 7523156-3 1994 Apparent phosphorylation of tyrosine residues was observed in addition to serine/threonine of the EGF receptor by EGF, but only a slightly if any tyrosine phosphorylation by TNF-alpha. Serine 74-80 epidermal growth factor receptor Homo sapiens 98-110 8700533-1 1996 Calmodulin-dependent protein kinase II (Cam kinase II) is known to desensitise epidermal growth factor receptor (HER-1) tyrosine kinase activity by a process involving phosphorylation at serines 1046/47 in the cytoplasmic tail. Serine 187-194 epidermal growth factor receptor Homo sapiens 79-111 8700533-1 1996 Calmodulin-dependent protein kinase II (Cam kinase II) is known to desensitise epidermal growth factor receptor (HER-1) tyrosine kinase activity by a process involving phosphorylation at serines 1046/47 in the cytoplasmic tail. Serine 187-194 epidermal growth factor receptor Homo sapiens 113-118 7536439-0 1995 In vivo and in vitro serine/threonine phosphorylations of epidermal growth factor receptor upon entry into the cell cycle. Serine 21-27 epidermal growth factor receptor Homo sapiens 58-90 7536439-3 1995 The epidermal growth factor receptor is phosphorylated primarily on serine and threonine, but not on tyrosine residues, in an S phase-dependent fashion, as determined by phosphoamino acid analysis and anti-phosphotyrosine immunoblotting. Serine 68-74 epidermal growth factor receptor Homo sapiens 4-36 7536439-7 1995 Although the mechanism for this ligand-independent phosphorylation is not known, its correlation with emergence from quiescence and entry into the cell cycle suggests that the phosphorylation of epidermal growth factor receptor on serine and threonine residues may have heretofore unknown role(s) in cell cycle entry and progression. Serine 231-237 epidermal growth factor receptor Homo sapiens 195-227 8555962-9 1995 In EC-R transfected cells the endogenous EGF-R showed enhanced phosphorylation of serine and threonine residues compared to EGF-R immunoprecipitated from control cells. Serine 82-88 epidermal growth factor receptor Homo sapiens 41-46 7812043-2 1994 Ser-1002 is followed immediately by Pro-1003, a residue that may promote the adoption of a specific conformation at this site or severe as a recognition element for the interaction of the EGF receptor with other proteins. Serine 0-3 epidermal growth factor receptor Homo sapiens 188-200 1480174-0 1992 Mutational removal of the major site of serine phosphorylation of the epidermal growth factor receptor causes potentiation of signal transduction: role of receptor down-regulation. Serine 40-46 epidermal growth factor receptor Homo sapiens 70-102 8106561-16 1994 However, the serine and threonine phosphorylation of the EGFR of APC-10 cells was consistently 2-3-fold lower than that seen in PC-10 cells. Serine 13-19 epidermal growth factor receptor Homo sapiens 57-61 7507488-15 1994 Findings iii and iv suggest that deNAcGM3 strongly promotes serine phosphorylation (in addition to Tyr phosphorylation) of EGF-R and may function as a second messenger in the process of cell growth stimulation. Serine 60-66 epidermal growth factor receptor Homo sapiens 123-128 7971947-0 1994 Comparison of conservation within and between the Ser/Thr and Tyr protein kinase family: proposed model for the catalytic domain of the epidermal growth factor receptor. Serine 50-53 epidermal growth factor receptor Homo sapiens 136-168 7505275-2 1994 We have found that calphostin-C induces substantial serine and threonine phosphorylation of the epidermal growth factor (EGF) receptor in a light-dependent fashion in the EGF receptor-hyperproducing squamous carcinoma cell line NA. Serine 52-58 epidermal growth factor receptor Homo sapiens 96-134 7505275-2 1994 We have found that calphostin-C induces substantial serine and threonine phosphorylation of the epidermal growth factor (EGF) receptor in a light-dependent fashion in the EGF receptor-hyperproducing squamous carcinoma cell line NA. Serine 52-58 epidermal growth factor receptor Homo sapiens 171-183 1379601-0 1992 Signal transduction by the epidermal growth factor receptor is attenuated by a COOH-terminal domain serine phosphorylation site. Serine 100-106 epidermal growth factor receptor Homo sapiens 27-59 1480174-1 1992 The major site of epidermal growth factor receptor (EGF-R) serine phosphorylation is located within the COOH-terminal domain of the receptor at Ser1046/7. Serine 59-65 epidermal growth factor receptor Homo sapiens 18-50 1480174-1 1992 The major site of epidermal growth factor receptor (EGF-R) serine phosphorylation is located within the COOH-terminal domain of the receptor at Ser1046/7. Serine 59-65 epidermal growth factor receptor Homo sapiens 52-57 1657956-4 1991 12-O-Tetradecanoylphorbol-13-acetate (TPA), a distinct tumor promoter and protein kinase C activator, also induces serine/threonine phosphorylation of the EGF receptor and is known to modulate receptor functions. Serine 115-121 epidermal growth factor receptor Homo sapiens 155-167 1349014-0 1992 Increased oncogenic potential of ErbB is associated with the loss of a COOH-terminal domain serine phosphorylation site. Serine 92-98 epidermal growth factor receptor Homo sapiens 33-37 1349014-9 1992 Here we show that the mutation of erbB at this negative regulatory serine phosphorylation site causes fibroblast transformation in vitro and is associated with an increased oncogenic potential in vivo. Serine 67-73 epidermal growth factor receptor Homo sapiens 34-38 1990291-2 1991 The stimulated EGF receptor coimmunoprecipitates with Raf-1 kinase and mediates protein kinase C-independent phosphorylation of Raf-1 on serine residues. Serine 137-143 epidermal growth factor receptor Homo sapiens 15-27 2105948-2 1990 The major sites of serine and threonine phosphorylation of the human epidermal growth factor (EGF) receptor observed in intact cells are Thr654, Thr669, Ser1046, and Ser1047. Serine 19-25 epidermal growth factor receptor Homo sapiens 69-107 2105948-5 1990 In order to test the hypothesis that the phosphorylation of the EGF receptor is mechanistically related to the modulation of EGF receptor function, we replaced the major sites of serine and threonine phosphorylation with alanine residues. Serine 179-185 epidermal growth factor receptor Homo sapiens 64-76 1688428-2 1990 Here we show transient increases in EGF-R serine/threonine phosphorylation which are temporally coordinated with the effects on EGF binding; we also demonstrate that the cytokine-mediated phosphorylations, unlike those caused by PKC activators, have little discernible effect upon intrinsic EGF-R-associated tyrosine kinase activity. Serine 42-48 epidermal growth factor receptor Homo sapiens 36-41