PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29981845-8 2018 Furthermore, we demonstrate that BVR-A impairment favors CK1-mediated Ser phosphorylation of BACE1 (known to mediate BACE1 recycling to plasma membrane) along with increased Abeta production in the parietal cortex, with age. Serine 70-73 biliverdin reductase A Homo sapiens 33-38 22584576-7 2012 LC-MS/MS analysis of PKCdelta-activated intact hBVR identified phosphorylated serine positions 21, 33, 230, and 237, corresponding to the hBVR Src homology-2 domain motif (Ser(230) and Ser(237)), flanking the ATP-binding motif (Ser(21)) and in PHPS sequence (Ser(33)) as targets of PKCdelta. Serine 78-84 biliverdin reductase A Homo sapiens 47-51 22584576-7 2012 LC-MS/MS analysis of PKCdelta-activated intact hBVR identified phosphorylated serine positions 21, 33, 230, and 237, corresponding to the hBVR Src homology-2 domain motif (Ser(230) and Ser(237)), flanking the ATP-binding motif (Ser(21)) and in PHPS sequence (Ser(33)) as targets of PKCdelta. Serine 172-175 biliverdin reductase A Homo sapiens 138-142 22584576-7 2012 LC-MS/MS analysis of PKCdelta-activated intact hBVR identified phosphorylated serine positions 21, 33, 230, and 237, corresponding to the hBVR Src homology-2 domain motif (Ser(230) and Ser(237)), flanking the ATP-binding motif (Ser(21)) and in PHPS sequence (Ser(33)) as targets of PKCdelta. Serine 78-84 biliverdin reductase A Homo sapiens 138-142 22584576-7 2012 LC-MS/MS analysis of PKCdelta-activated intact hBVR identified phosphorylated serine positions 21, 33, 230, and 237, corresponding to the hBVR Src homology-2 domain motif (Ser(230) and Ser(237)), flanking the ATP-binding motif (Ser(21)) and in PHPS sequence (Ser(33)) as targets of PKCdelta. Serine 185-188 biliverdin reductase A Homo sapiens 47-51 22584576-7 2012 LC-MS/MS analysis of PKCdelta-activated intact hBVR identified phosphorylated serine positions 21, 33, 230, and 237, corresponding to the hBVR Src homology-2 domain motif (Ser(230) and Ser(237)), flanking the ATP-binding motif (Ser(21)) and in PHPS sequence (Ser(33)) as targets of PKCdelta. Serine 185-188 biliverdin reductase A Homo sapiens 47-51 22584576-7 2012 LC-MS/MS analysis of PKCdelta-activated intact hBVR identified phosphorylated serine positions 21, 33, 230, and 237, corresponding to the hBVR Src homology-2 domain motif (Ser(230) and Ser(237)), flanking the ATP-binding motif (Ser(21)) and in PHPS sequence (Ser(33)) as targets of PKCdelta. Serine 172-175 biliverdin reductase A Homo sapiens 47-51 22584576-7 2012 LC-MS/MS analysis of PKCdelta-activated intact hBVR identified phosphorylated serine positions 21, 33, 230, and 237, corresponding to the hBVR Src homology-2 domain motif (Ser(230) and Ser(237)), flanking the ATP-binding motif (Ser(21)) and in PHPS sequence (Ser(33)) as targets of PKCdelta. Serine 185-188 biliverdin reductase A Homo sapiens 47-51 22584576-8 2012 Ser(21) and Ser(230) were also phosphorylated in hBVR-based peptides. Serine 0-3 biliverdin reductase A Homo sapiens 49-53 21241799-1 2011 Biliverdin reductase-A is a pleiotropic enzyme involved not only in the reduction of biliverdin-IX-alpha into bilirubin-IX-alpha, but also in the regulation of glucose metabolism and cell growth secondary to its serine/threonine/tyrosine kinase activity. Serine 212-218 biliverdin reductase A Homo sapiens 0-22 22584576-8 2012 Ser(21) and Ser(230) were also phosphorylated in hBVR-based peptides. Serine 12-15 biliverdin reductase A Homo sapiens 49-53 21241799-4 2011 Moreover a significant reduction in the phosphorylation of serine, threonine and tyrosine residues of biliverdin reductase-A was found, and this was paralleled by a marked reduction in its reductase activity. Serine 59-65 biliverdin reductase A Homo sapiens 102-124 21241799-6 2011 These results demonstrated a dichotomy between biliverdin reductase-A protein levels and activity in the hippocampus of subjects affected by Alzheimer disease and mild cognitive impairment, and this effect likely is attributable to a reduction in the phosphorylation of serine, threonine and tyrosine residues of biliverdin reductase-A. Serine 270-276 biliverdin reductase A Homo sapiens 47-69 34224815-2 2021 Furthermore, BVR is also endowed with both serine/threonine/tyrosine kinase and scaffold activities, through which it interacts with the insulin receptor kinase, conventional and atypical protein kinase C isoforms, mitogen-activated protein kinases as well as the phosphatidylinositol-3 kinase/Akt system. Serine 43-49 biliverdin reductase A Homo sapiens 13-16 21483094-2 2011 Together with heme oxygenase, BVR-A forms a powerful system involved in the cell stress response during neurodegenerative disorders including Alzheimer"s disease (AD), whereas due to the serine/threonine/tyrosine kinase activity the enzyme regulates glucose metabolism and cell proliferation. Serine 187-193 biliverdin reductase A Homo sapiens 30-35 17227757-1 2007 Human biliverdin reductase (hBVR), a dual specificity kinase (Ser/Thr/Tyr) is, as protein kinase C (PKC) betaII, activated by insulin and free radicals (Miralem, T., Hu, Z., Torno, M. D., Lelli, K. M., and Maines, M. D. (2005) J. Biol. Serine 62-65 biliverdin reductase A Homo sapiens 28-32 15870194-2 2005 BVR is both a substrate for insulin receptor (IR) tyrosine kinase (IRK) activity and a kinase for serine phosphorylation of IR substrate 1 (IRS-1). Serine 98-104 biliverdin reductase A Homo sapiens 0-3 15870194-8 2005 Serine residues in IRS-1 are targets for BVR phosphorylation, and point mutation of serine residues in the kinase domain of the reductase inhibits phosphotransferase activity. Serine 0-6 biliverdin reductase A Homo sapiens 41-44 15870194-9 2005 Because tyrosine phosphorylation of IRS-1 activates the insulin signaling pathway and serine phosphorylation of IRS-1 blocks insulin action, our findings that insulin increases BVR tyrosine phosphorylation and that there is an increase in glucose uptake in response to insulin when expression of BVR is "knocked down" by small interfering RNA suggest a potential role for BVR in the insulin signaling pathway. Serine 86-92 biliverdin reductase A Homo sapiens 177-180 15870194-9 2005 Because tyrosine phosphorylation of IRS-1 activates the insulin signaling pathway and serine phosphorylation of IRS-1 blocks insulin action, our findings that insulin increases BVR tyrosine phosphorylation and that there is an increase in glucose uptake in response to insulin when expression of BVR is "knocked down" by small interfering RNA suggest a potential role for BVR in the insulin signaling pathway. Serine 86-92 biliverdin reductase A Homo sapiens 296-299 15870194-9 2005 Because tyrosine phosphorylation of IRS-1 activates the insulin signaling pathway and serine phosphorylation of IRS-1 blocks insulin action, our findings that insulin increases BVR tyrosine phosphorylation and that there is an increase in glucose uptake in response to insulin when expression of BVR is "knocked down" by small interfering RNA suggest a potential role for BVR in the insulin signaling pathway. Serine 86-92 biliverdin reductase A Homo sapiens 296-299 19217170-2 2009 It is now recognized that human BVR (hBVR) is a dual-specificity kinase (Ser/Thr and Tyr) upstream activator of the insulin/insulin growth factor-1 (IGF-1) and mitogen-activated protein kinase (MAPK) signaling pathways. Serine 73-76 biliverdin reductase A Homo sapiens 32-35 19217170-2 2009 It is now recognized that human BVR (hBVR) is a dual-specificity kinase (Ser/Thr and Tyr) upstream activator of the insulin/insulin growth factor-1 (IGF-1) and mitogen-activated protein kinase (MAPK) signaling pathways. Serine 73-76 biliverdin reductase A Homo sapiens 37-41 15741166-5 2005 Activation of BVR involved increased serine/threonine phosphorylation but not its protein or transcript levels. Serine 37-43 biliverdin reductase A Homo sapiens 14-17