PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33906557-5	2022	Here, we review the physiological role of autophagy in the context of intestinal epithelial maintenance and how genetic mutations affecting autophagy contribute to the development of intestinal disease.Abbreviations: AKT1S1: AKT1 substrate 1; AMBRA1: autophagy and beclin 1 regulator 1; AMPK: AMP-activated protein kinase; APC: APC regulator of WNT signaling pathway; ATF6: activating transcription factor 6; ATG: autophagy related; atg16l1[DeltaIEC] mice: mice with a specific deletion of Atg16l1 in intestinal epithelial cells; ATP: adenosine triphosphate; BECN1: beclin 1; bsk/Jnk: basket; CADPR: cyclic ADP ribose; CALCOCO2: calcium binding and coiled-coil domain 2; CASP3: caspase 3; CD: Crohn disease; CDH1/E-cadherin: cadherin 1; CF: cystic fibrosis; CFTR: CF transmembrane conductance regulator; CGAS: cyclic GMP-AMP synthase; CLDN2: claudin 2; CoPEC: colibactin-producing E. coli; CRC: colorectal cancer; CYP1A1: cytochrome P450 family 1 subfamily A member 1; DC: dendritic cell; DDIT3: DNA damage inducible transcript 3; DEPTOR: DEP domain containing MTOR interacting protein; DSS: dextran sulfate sodium; EGF: epidermal growth factor; EGFR: epidermal growth factor receptor; EIF2A: eukaryotic translation initiation factor 2A; EIF2AK3: eukaryotic translation initiation factor 2 alpha kinase 3; EIF2AK4/GCN2: eukaryotic translation initiation factor 2 alpha kinase 4; ER: endoplasmic reticulum; ERN1: endoplasmic reticulum to nucleus signaling 1; GABARAP: GABA type A receptor-associated protein; HMGB1: high mobility group box 1; HSPA5/GRP78: heat shock protein family A (Hsp70) member 5; IBD: inflammatory bowel disease; IEC: intestinal epithelial cell; IFN: interferon; IFNG/IFNgamma:interferon gamma; IL: interleukin; IRGM: immunity related GTPase M; ISC: intestinal stem cell; LGR5: leucine rich repeat containing G protein-coupled receptor 5; LRRK2: leucine rich repeat kinase 2; MAP1LC3A/LC3: microtubule associated protein 1 light chain 3 alpha; MAPK/JNK: mitogen-activated protein kinase; MAPK14/p38 MAPK: mitogen-activated protein kinase 14; MAPKAP1: MAPK associated protein 1; MAVS: mitochondrial antiviral signaling protein; miRNA: microRNA; MLKL: mixed lineage kinase domain like pseudokinase; MLST8: MTOR associated protein, LST8 homolog; MNV: murine norovirus; MTOR: mechanistic target of rapamycin kinase; NBR1: NBR1 autophagy cargo receptor; NLRP: NLR family pyrin domain containing; NOD: nucleotide binding oligomerization domain containing; NRBF2: nuclear receptor binding factor 2; OPTN: optineurin; OXPHOS: oxidative phosphorylation; P: phosphorylation; Patj: PATJ crumbs cell polarity complex component; PE: phosphatidyl-ethanolamine; PI3K: phosphoinositide 3-kinase; PIK3C3/VPS34: phosphatidylinositol 3-kinase catalytic subunit type 3; PIK3R4: phosphoinositide-3-kinase regulatory subunit 4; PPARG: peroxisome proliferator activated receptor gamma; PRR5: proline rich 5; PRR5L: proline rich 5 like; PtdIns3K: phosphatidylinositol 3-kinase; PtdIns3P: phosphatidylinositol 3-phosphate; RB1CC1/FIP200: RB1 inducible coiled-coil 1; RER: rough endoplasmic reticulum; RHEB: Ras homolog, MTORC1 binding; RICTOR: RPTOR independent companion of MTOR complex 2; RIPK1: receptor interacting serine/threonine kinase 1; ROS: reactive oxygen species; RPTOR: regulatory associated protein of MTOR complex 1; RPS6KB1: ribosomal protein S6 kinase B1; SH3GLB1: SH3 domain containing GRB2 like, endophilin B1; SNP: single-nucleotide polymorphism; SQSTM1: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STING1: stimulator of interferon response cGAMP interactor 1; TA: transit-amplifying; TFEB: transcription factor EB; TFE3: transcription factor binding to IGHM enhancer 3; TGM2: transglutaminase 2; TJ: tight junction; TJP1/ZO1: tight junction protein 1; TNBS: 2,4,6-trinitrobenzene sulfonic acid; TNF/TNFalpha: tumor necrosis factor; Tor: target of rapamycin; TRAF: TNF receptor associated factor; TRIM11: tripartite motif containing 11; TRP53: transformation related protein 53; TSC: TSC complex subunit; Ub: ubiquitin; UC: ulcerative colitis; ULK1: unc-51 like autophagy activating kinase 1; USO1/p115: USO1 vesicle transport factor; UVRAG: UV radiation resistance associated; WIPI: WD repeat domain, phosphoinositide interacting; WNT: WNT family member; XBP1: X-box binding protein 1; ZFYVE1/DFCP1: zinc finger FYVE-type containing 1.	Serine	3215-3221	thymoma viral proto-oncogene 1	Mus musculus	217-221	
34014413-8	2021	Further study revealed that serum-derived exosomes enhanced phosphorylation of the serine-threonine kinase Akt in scalded skin tissue.	Serine	83-89	thymoma viral proto-oncogene 1	Mus musculus	107-110	
33985544-7	2021	Our data show that AKT can directly phosphorylate Sox9 in vitro at serine 181 and that AKT inhibition blocks Sox9 phosphorylation and Sox10 expression in SLK(-/-) tumor cells.	Serine	67-73	thymoma viral proto-oncogene 1	Mus musculus	19-22	
33839150-6	2021	Alpha cell lines with stable IRS1 knockdown (alphaIRS1KD) could not repress glucagon mRNA expression and exhibited a reduction in phosphorylation of AKT Ser/Thr kinase (AKT, at Ser-473 and Thr-308).	Serine	153-156	thymoma viral proto-oncogene 1	Mus musculus	149-152	
33189893-1	2021	BACKGROUND&AIMS: PAK1 belongs to a family of serine-threonine kinases and contributes to cellular pathways like NFkappaB, MAPK, PI3K/AKT and Wnt/ beta-catenin all of which are involved in intestinal homeostasis.	Serine	45-51	thymoma viral proto-oncogene 1	Mus musculus	133-136	
33226552-7	2021	Akt phosphorylation additionally phosphorylates Bad at serine-136 and inhibits its translocation to mitochondria thereby promoting mitochondrial biogenesis, enhanced ATP production and inhibit apoptosis mediated neuronal death.	Serine	55-61	thymoma viral proto-oncogene 1	Mus musculus	0-3	
33468664-4	2021	Akt phosphorylation of Mdm2 serine residue 183 increases nuclear Mdm2 stability, decreases p53 levels, and prevents senescence in primary cells exposed to reactive oxidative species (ROS).	Serine	28-34	thymoma viral proto-oncogene 1	Mus musculus	0-3	
33469368-10	2021	CircEIF6 silencing also hampered the activation of phosphatidylinositol 3-kinase (PI3K)/AKT serine/threonine kinase (AKT) pathway.	Serine	92-98	thymoma viral proto-oncogene 1	Mus musculus	88-91	
33869980-5	2021	Strikingly, VAT removal prevents obesity-induced insulin resistance and hyperinsulinemia and markedly enhances insulin-stimulated AKT-phosphorylation at serine-473 (Ser473) and threonine-308 (Thr308) sites in SAT, liver, and skeletal muscle.	Serine	153-159	thymoma viral proto-oncogene 1	Mus musculus	130-133	
32566257-4	2020	Mechanistic studies revealed inhibition of AMP-activated protein kinase (AMPK) phosphorylation at Thr-172 and activation of Akt phosphorylation at Ser-473 and Thr-308.	Serine	147-150	thymoma viral proto-oncogene 1	Mus musculus	124-127	
33240105-11	2020	We identified serine 861 in mouse HCN2 as a putative Akt phosphorylation site.	Serine	14-20	thymoma viral proto-oncogene 1	Mus musculus	53-56	
32786820-8	2020	However, some of key bone formatting factors such as ALP synthesis and serine residue phosphorylation of Akt by ovotransferrin remained independent of LRP1.	Serine	71-77	thymoma viral proto-oncogene 1	Mus musculus	105-108	
32531473-6	2020	In the immunoblot analysis, memantine significantly increased phosphorylation of CaMKIV (Thr-196) and Akt (Ser-473), but not ERK (Thr-202/Tyr-204), in the DG of OBX mice.	Serine	107-110	thymoma viral proto-oncogene 1	Mus musculus	102-105	
32531473-9	2020	Furthermore, the increase in CaMKIV (Thr-196) and Akt (Ser-473) phosphorylation and BDNF protein expression levels was not observed in OBX-treated Kir6.1 +/- mice.	Serine	55-58	thymoma viral proto-oncogene 1	Mus musculus	50-53	
33328854-3	2020	Glycogen synthase kinase-3beta (GSK3beta), as a major Tau kinase and a downstream target of the serine protein kinase B (AKT) signaling pathway, can regulate Tau phosphorylation in AD.	Serine	96-102	thymoma viral proto-oncogene 1	Mus musculus	121-124	
32450252-6	2020	In contrast, Akt-mediated phosphorylation of two serine residues of Mdm2 partly regulated the nuclear entry of Mdm2.	Serine	49-55	thymoma viral proto-oncogene 1	Mus musculus	13-16	
32144123-8	2020	eNOS (Ser-1177) and AKT (Ser-473) phosphorylation were decreased (P<0.05) in the bladder of SCD compared to WT mice and reversed by NO-np.	Serine	25-28	thymoma viral proto-oncogene 1	Mus musculus	20-23	
31936236-4	2020	We established that IGF-1 induced BNIP3 expression through a known AKT serine/threonine kinase 1 (AKT)-mediated inhibitory phosphorylation on Glycogen Synthase Kinase-3beta (GSK-3beta), leading to activation of Nuclear Factor Erythroid 2-related Factor 2 (NFE2L2/Nrf2) and acting through the downstream transcriptional regulators Nuclear Respiratory Factor-1 (NRF1) and Hypoxia-inducible Factor 1 subunit alpha (HIF-1alpha).	Serine	71-77	thymoma viral proto-oncogene 1	Mus musculus	67-70	
32312949-8	2020	Also, loss of AKAP1 decreases Akt phosphorylation at Serine 473 (Ser473) and threonine 308 (Thr308) and activates the Bim/Bax signaling pathway in the retina.	Serine	53-59	thymoma viral proto-oncogene 1	Mus musculus	30-33	
31981662-5	2020	In mechanism study, it was found that KMPS reduced the serine phosphorylation of IRS-1 by inhibiting the activation of the NF-kappaB pathway, thereby restoring the utilization of glucose by the PI3K/AKT pathway.	Serine	55-61	thymoma viral proto-oncogene 1	Mus musculus	199-202	
31215069-3	2020	Hyperactivated phosphoinositide 3-kinase (PI3K)/Akt serine/threonine kinase (Akt) and mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling pathways play central roles in cancer cell metabolic adaptation given that their downstream effectors, such as Akt and c-Myc, control most of the glycolytic and glutaminolysis genes.	Serine	52-58	thymoma viral proto-oncogene 1	Mus musculus	48-51	
30984553-2	2019	In the present study, we investigated the role of the serine/threonine kinase Akt in angiogenesis.	Serine	54-60	thymoma viral proto-oncogene 1	Mus musculus	78-81	
32432228-6	2020	This led to decreased Akt phosphorylation on serine 473 and increased cleavage of caspase 3.	Serine	45-51	thymoma viral proto-oncogene 1	Mus musculus	22-25	
31852639-1	2019	OBJECTIVE: To investigate the role of the protein-serine-threonine kinase (AKT)/glycogen synthase kinase 3beta (GSK3beta) signaling pathway in nicotinic acetylcholine receptors (nAChRs) aggregation disorder on skeletal muscle cell membranes induced by sepsis.	Serine	50-56	thymoma viral proto-oncogene 1	Mus musculus	75-78	
30734931-5	2019	We provide evidence using primary cortical cultured neurons from Pink1-deficient mice that Pink1 increases AKT phosphorylation at Serine 473 (Ser473) challenged by 1-methyl-4-phenylpyridinium (MPP+ ) and that over-expression of FKBP5 using an adeno-associated virus delivery system negatively regulates AKT phosphorylation at Ser473 in murine-cultured cortical neurons.	Serine	130-136	thymoma viral proto-oncogene 1	Mus musculus	107-110	
31272455-5	2019	Mechanistically, we found that upregulation in MMP expression associated with increased activity of the serine/threonine kinase Akt, and pharmacological inhibition of this enzyme resulted in a dramatic suppression of MMP expression in Ap3b1 deficient lung epithelial cells.	Serine	104-110	thymoma viral proto-oncogene 1	Mus musculus	128-131	
30975706-6	2019	Reduction of forkhead box O1 (FOXO1) with increased phosphorylation of upstream serine/threonine kinase (AKT) was detected under HBx Mut overexpression.	Serine	80-86	thymoma viral proto-oncogene 1	Mus musculus	105-108	
31205027-7	2019	This Gs/PKA-mediated pathway synergized with the AKT-mediated pathways leading to eNOS phosphorylation at serine 1177.	Serine	106-112	thymoma viral proto-oncogene 1	Mus musculus	49-52	
30980895-8	2019	Mechanistically, we found that IRW treatment resulted in a 4-fold increase of Akt serine phosphorylation and a 2-fold increase of its downstream target RUNX2.	Serine	82-88	thymoma viral proto-oncogene 1	Mus musculus	78-81	
30362584-3	2019	The phospho-Akt (Ser 473), phospho-Akt (Thr 308), and SREBP-1 expression were inhibited in the sciatic nerves of diabetic mice versus those of normal mice, accompanied with the atrophy of nerve fiber and the irregular myelin sheath.	Serine	17-20	thymoma viral proto-oncogene 1	Mus musculus	12-15	
31461543-10	2019	The latter involves GSK3beta inhibitory serine 9 phosphorylation downstream of Akt activation but not HDAC6 activity.	Serine	40-46	thymoma viral proto-oncogene 1	Mus musculus	79-82	
30885348-9	2019	In PTEN-KO cells, the levels of phosphorylated AKT (Ser-473 and Thr-308) were profoundly elevated and the expressions of phosphorylated GSK-3beta (Ser9, inactive form) increased, while that of beta-catenin decreased.	Serine	52-55	thymoma viral proto-oncogene 1	Mus musculus	47-50	
30592148-8	2019	Functional and pathway enrichment analyses revealed that these DEGs were closely related to cellular activity, androgen synthesis, DNA damage and repair, also involved in the ERK/MAPK, PI3K/serine-threonine protein kinase, also known as protein kinase B, PKB (AKT) and apoptosis signalling pathways.	Serine	190-196	thymoma viral proto-oncogene 1	Mus musculus	255-258	
30592148-8	2019	Functional and pathway enrichment analyses revealed that these DEGs were closely related to cellular activity, androgen synthesis, DNA damage and repair, also involved in the ERK/MAPK, PI3K/serine-threonine protein kinase, also known as protein kinase B, PKB (AKT) and apoptosis signalling pathways.	Serine	190-196	thymoma viral proto-oncogene 1	Mus musculus	260-263	
29391600-3	2018	By dephosphorylating specific serine residues in the hydrophobic motif, PHLPP1 and PHLPP2 restrain AKT signalings, thereby regulating cell proliferation and survival.	Serine	30-36	thymoma viral proto-oncogene 1	Mus musculus	99-102	
29669220-4	2018	This study investigated the temporal patterns and prospective role(s) for interactions between SUMOylation and Akt serine-phosphorylation during oocyte meiotic resumption.	Serine	115-121	thymoma viral proto-oncogene 1	Mus musculus	111-114	
29588368-8	2018	Thus, CLOCK phosphorylation by AKT on Ser-845 regulates its nuclear translocation and the expression levels of certain core circadian genes in insulin-sensitive tissues.	Serine	38-41	thymoma viral proto-oncogene 1	Mus musculus	31-34	
29454793-15	2018	In HSCs, substrate stiffness activated AKT signaling via RHOA to induce phosphorylation of p300 at serine 1834; this caused p300 to translocate to the nucleus, where it up-regulated transcription of genes that increase activation of HSCs and metastasis, including CXCL12.	Serine	99-105	thymoma viral proto-oncogene 1	Mus musculus	39-42	
29474930-4	2018	Insulin-stimulated insulin receptor tyrosine and Akt serine phosphorylation markedly increased in Prep1i/+ mice, paralleled by 3-fold higher glucose uptake and a significant increase of proadipogenic genes such as C/EBPalpha, GLUT4, and FABP4.	Serine	53-59	thymoma viral proto-oncogene 1	Mus musculus	49-52	
30018139-6	2018	SCF/c-Kit-mediated phosphorylation of P38, STAT1, Akt (Thr-308), and Akt (Ser-473) was also significantly reduced in c-Kit+ cells from Fpr2-/- mice.	Serine	74-77	thymoma viral proto-oncogene 1	Mus musculus	69-72	
28526415-8	2017	Consistently, LNK specific siRNA further decreased the Akt Ser-473 phosphorylation reduced by palmitate and located on upstream of Bax and cytochrome C. The siRNA-mediated LNK knockdown exacerbated mitochondrial membrane depolarization and mitochondrial-derived reactive oxygen species production induced by palmitate, whereas overexpression of LNK attenuated that.	Serine	59-62	thymoma viral proto-oncogene 1	Mus musculus	55-58	
29472543-8	2018	PI3K-Akt pathway and H3K27me3 form a feedback loop in rd1 retina, thus PI3K inhibitor LY294002 reduces phosphorylation of Ezh2 at serine 21 and enhances H3K27me3 deposition, and inhibiting H3K27me3 by DZNep can activate PI3K-Akt pathway by de-repressing gene expression of PI3K subunits Pik3r1 and Pik3r3.	Serine	130-136	thymoma viral proto-oncogene 1	Mus musculus	5-8	
27966074-7	2018	Phosphorylation of Akt at serine 473 (AktpSer473) and of GSK3 at serine 9 (GSK3betapSer9) were also decreased in hippocampi of post-septic animals, further indicating that brain insulin signaling is disrupted by sepsis.	Serine	26-32	thymoma viral proto-oncogene 1	Mus musculus	19-22	
28756309-5	2017	Simultaneously, metabolic homeostatic factors were critical for glucose metabolism, including phosphorylated adenosine monophosphate-activated protein kinase (AMPK) and AKT serine/threonine kinase.	Serine	173-179	thymoma viral proto-oncogene 1	Mus musculus	169-172	
28425986-6	2017	The Akt inhibitor MK-2206 decreased the expression of p16 and Bmi1 serine phosphorylation.	Serine	67-73	thymoma viral proto-oncogene 1	Mus musculus	4-7	
28559285-7	2017	Akt kinase activity was higher in HCV mice than in WT mice, but Akt-dependent phosphorylation of the forkhead transcription factor FoxO1 at serine 256, which triggers its nuclear exclusion, was lower in HCV mouse livers.	Serine	140-146	thymoma viral proto-oncogene 1	Mus musculus	64-67	
28490443-7	2017	The IR-B isoform phosphorylated at tyrosines 1150/1151 was increased, but the AKT phosphorylation in serine 473 was reduced in cKD-ILK tissues.	Serine	101-107	thymoma viral proto-oncogene 1	Mus musculus	78-81	
28075049-4	2017	The decreased SHIP and increased phospho-Akt (Ser 473, Thr 308) were found in the renal tubular cells of diabetic mice, which were accompanied by overexpression of transforming growth factor-beta1 (TGF-beta1), alpha-smooth muscle actin (alpha-SMA), and secreted collagen type 3 (Col 3) and a low expression of E-cadherin compared to that in normal mice.	Serine	46-49	thymoma viral proto-oncogene 1	Mus musculus	41-44	
27799485-8	2017	In mechanistic studies, we showed coimmunoprecipitation of PKCdelta and AKT from lysates of cisplatin-treated cells and direct phosphorylation of AKT at serine-473 by PKCdeltain vitro Finally, administration of the PKCdelta inhibitor rottlerin with cisplatin protected against cisplatin nephrotoxicity in wild-type mice, but not in renal autophagy-deficient mice.	Serine	153-159	thymoma viral proto-oncogene 1	Mus musculus	146-149	
29035165-6	2017	Here we report the development of highly sensitive in-vitro cell-based kinase ELISA which quantifies the phosphorylated AKT kinase (serine 473) and total AKT kinase directly within the cells upon compound treatment.	Serine	132-138	thymoma viral proto-oncogene 1	Mus musculus	120-123	
28440748-3	2017	Membrane-located SCP1 dephosphorylates AKT at serine 473, leading to the abolishment of serine 473 phosphorylation that results in suppressed angiogenesis and a decreased risk of tumorigenesis.	Serine	46-52	thymoma viral proto-oncogene 1	Mus musculus	39-42	
28440748-3	2017	Membrane-located SCP1 dephosphorylates AKT at serine 473, leading to the abolishment of serine 473 phosphorylation that results in suppressed angiogenesis and a decreased risk of tumorigenesis.	Serine	88-94	thymoma viral proto-oncogene 1	Mus musculus	39-42	
28319140-3	2017	We also evaluated the responses to leptin and the activity of the insulin signalling pathway in skeletal muscle and liver by phosphorylation of Akt at Ser 473.	Serine	151-154	thymoma viral proto-oncogene 1	Mus musculus	144-147	
27935220-3	2017	Myotubes as compared to myoblasts of C2 C12 cells were found to be more sensitive in response to insulin as increase in insulin-stimulated phosphorylation of AKT at serine 473 residue (pAKTS473 ) was significantly higher in myotubes.	Serine	165-171	thymoma viral proto-oncogene 1	Mus musculus	158-161	
27775852-3	2017	Acute cotinine treatment increased the inhibitory serine-phosphorylation of GSK3beta and the activating phosphorylation of AKT, which can mediate serine-phosphorylation of GSK3beta, in both wild-type and Fmr1-/- mouse hippocampus.	Serine	146-152	thymoma viral proto-oncogene 1	Mus musculus	123-126	
28123351-5	2017	Knockdown of Rictor by shRNA significantly reduced the phosphorylation of Akt at serine 473 followed by a decrease in cardiomyocyte differentiation detected by beating embryoid bodies.	Serine	81-87	thymoma viral proto-oncogene 1	Mus musculus	74-77	
27344443-3	2016	In cultured adipocytes, Syap1 functions as part of a complex that phosphorylates protein kinase Balpha/Akt1 (Akt1) at Ser(473) and promotes differentiation.	Serine	118-121	thymoma viral proto-oncogene 1	Mus musculus	103-107	
26523428-11	2016	Furthermore, pre-treatment of the primary MRPE cells with ZnS-NPs led to phosphorylation of Akt (Ser 473), which indicates the crucial role of ZnS-NPs in regulating cell survival at minimal concentration.	Serine	97-100	thymoma viral proto-oncogene 1	Mus musculus	92-95	
27344443-3	2016	In cultured adipocytes, Syap1 functions as part of a complex that phosphorylates protein kinase Balpha/Akt1 (Akt1) at Ser(473) and promotes differentiation.	Serine	118-121	thymoma viral proto-oncogene 1	Mus musculus	109-113	
27412013-5	2016	In vivo, DNA-PKcs knockdown or oral administration of the DNA-PKcs inhibitor NU-7441 inhibited AKT Ser-473 phosphorylation, HIF-2alpha expression and 786-0 RCC xenograft growth in nude mice.	Serine	99-102	thymoma viral proto-oncogene 1	Mus musculus	95-98	
27525439-3	2016	HTT has a highly conserved Akt phosphorylation site at serine 421, and prior work in HD models found that phosphorylation at S421 (S421-P) diminishes the toxicity of mutant HTT (mHTT) fragments in neuronal cultures.	Serine	55-61	thymoma viral proto-oncogene 1	Mus musculus	27-30	
27226588-8	2016	In addition, Zfat deficiency increases the phosphorylation levels of Thr-308 and Ser-473 of Akt and the relative amounts of cytoplasmic to nuclear FoxO1 protein levels, indicating that Zfat deficiency causes Akt activation, leading to nuclear exclusion of FoxO1.	Serine	81-84	thymoma viral proto-oncogene 1	Mus musculus	92-95	
27106789-5	2016	We find that CXCR4 signaling activates mTORC2 as indicated by phosphorylation of serine 473 on Akt and does so through a G-protein- and PI3K-dependent pathway.	Serine	81-87	thymoma viral proto-oncogene 1	Mus musculus	95-98	
27000529-6	2016	Sakuranetin was also found to inhibit the phosphorylation of AKT at threonine 308 and serine 473 and leads to activation of GSK3beta via decreased phosphorylation at serine 9.	Serine	86-92	thymoma viral proto-oncogene 1	Mus musculus	61-64	
27000529-6	2016	Sakuranetin was also found to inhibit the phosphorylation of AKT at threonine 308 and serine 473 and leads to activation of GSK3beta via decreased phosphorylation at serine 9.	Serine	166-172	thymoma viral proto-oncogene 1	Mus musculus	61-64	
26407610-4	2016	Our data show that in antigen-activated mast cells, reduced expression of the ORMDL3 protein had no effect on degranulation and calcium response, but significantly enhanced phosphorylation of AKT kinase at Ser 473 followed by enhanced phosphorylation and degradation of IkappaBalpha and translocation of the NF-kappaB p65 subunit into the nucleus.	Serine	206-209	thymoma viral proto-oncogene 1	Mus musculus	192-195	
26447680-6	2016	Again, in vitro experiment revealed 1.89, 2.18, 1.92, 3.06, 2.06-fold increases of phospho-Akt (Ser 473), phospho-Akt (Thr 308), CTGF, secreted fibronectin, and secreted Col 3 in high glucose-stimulated HKC cells in comparison with normal control cells.	Serine	96-99	thymoma viral proto-oncogene 1	Mus musculus	91-94	
26988296-8	2016	Insulin-stimulated serine-phosphorylation of Akt and glucose transporter 4 translocation were decreased in the skeletal muscle of MI compared to Sham by 57% and 69%, and both changes were ameliorated in the MI+Aliskiren group (91% and 94%).	Serine	19-25	thymoma viral proto-oncogene 1	Mus musculus	45-48	
26447680-10	2016	The treatment of LY294002 inhibited phospho-Akt (Ser 473) and phospho-Akt (Thr 308) expression followed by decreased CTGF, secretory fibronectin and secretory Col 3 in high glucose-treated HKC cells.	Serine	49-52	thymoma viral proto-oncogene 1	Mus musculus	44-47	
26739493-6	2016	PKCbetaII via its phosphorylation at Ser-660 regulated phosphorylation of Akt at both catalytic loop and hydrophobic motif sites, resulting in phosphorylation and inactivation of its substrate PRAS40.	Serine	37-40	thymoma viral proto-oncogene 1	Mus musculus	74-77	
26739493-10	2016	Finally, using renal cortexes from type 1 diabetic mice, we found that increased phosphorylation of PKCbetaII at Ser-660 was associated with enhanced Akt phosphorylation and mTORC1 activation.	Serine	113-116	thymoma viral proto-oncogene 1	Mus musculus	150-153	
26393439-10	2015	These findings suggest an important role of Girdin phosphorylation at serine 1416 in cardiac repair after acute myocardial infarction and provide insights into the complex mechanism of cardiac rupture through the Akt/Girdin-mediated regulation of cardiac myofibroblasts.	Serine	70-76	thymoma viral proto-oncogene 1	Mus musculus	213-216	
26722032-7	2016	RESULTS: Torin2 exhibited greater efficacy in cell growth inhibition than rapamycin, associated with a strong reduction of phosphorylated v-akt murine thymoma viral oncogene homolog (AKT) (Ser 473), that is downstream of mTORC2.	Serine	189-192	thymoma viral proto-oncogene 1	Mus musculus	183-186	
25968579-6	2015	LIF increased Akt Ser(473) phosphorylation (P) in soleus and EDL, whereas AMPK Thr(172) P was unaffected.	Serine	18-21	thymoma viral proto-oncogene 1	Mus musculus	14-17	
26254337-6	2015	Chemerin significantly increased ROS production in SMCs and phosphorylation of Akt (Ser(473)) and ERK, as measured by fluorescent staining and Western blot analysis, respectively.	Serine	84-87	thymoma viral proto-oncogene 1	Mus musculus	79-82	
25858697-7	2015	Chronic melatonin treatment attenuated the hyperphosphorylation of tau protein via PI3K/Akt/GSK3beta signaling by activating the p-PI3K, p-Akt (Ser 473) and p-GSK3beta (Ser9) in the Abeta1-42-treated mice.	Serine	144-147	thymoma viral proto-oncogene 1	Mus musculus	88-91	
25858697-7	2015	Chronic melatonin treatment attenuated the hyperphosphorylation of tau protein via PI3K/Akt/GSK3beta signaling by activating the p-PI3K, p-Akt (Ser 473) and p-GSK3beta (Ser9) in the Abeta1-42-treated mice.	Serine	144-147	thymoma viral proto-oncogene 1	Mus musculus	139-142	
26100639-9	2015	IR also resulted in the overactivation of Akt by AICAR treatment; however, preventing Akt overactivation during IR prevented AMPK(Ser-485) hyperphosphorylation and restored AMPK-mediated Tau dephosphorylation.	Serine	130-133	thymoma viral proto-oncogene 1	Mus musculus	42-45	
26100639-9	2015	IR also resulted in the overactivation of Akt by AICAR treatment; however, preventing Akt overactivation during IR prevented AMPK(Ser-485) hyperphosphorylation and restored AMPK-mediated Tau dephosphorylation.	Serine	130-133	thymoma viral proto-oncogene 1	Mus musculus	86-89	
26100639-11	2015	Therefore, our results suggest the following mechanism for the adverse effect of IR on AD pathology: IR   chronic overactivation of Akt   AMPK(Ser-485) hyperphosphorylation   inhibition of AMPK-mediated Tau dephosphorylation.	Serine	143-146	thymoma viral proto-oncogene 1	Mus musculus	132-135	
25713323-4	2015	In the liver, there was a 2.5-fold increase in insulin stimulated Akt(SER) (473) phosphorylation, and a threefold increase in insulin-stimulated (0.5 U/kg) GSK3beta(SER) (9) phosphorylation in RUN compared to SED mice.	Serine	70-73	thymoma viral proto-oncogene 1	Mus musculus	66-69	
25790950-3	2015	The PI3K regulatory subunit p85alpha and phosphorylation of Akt on serine 473 (p-Akt S473) are downregulated in sensory hair cells, including both outer and inner hair cells, and supporting cells of the mouse organ of Corti 1 h after exposure to permanent-threshold-shift-inducing noise (PTS noise), but not with temporary-threshold-shift-inducing noise (TTS noise).	Serine	67-73	thymoma viral proto-oncogene 1	Mus musculus	60-63	
25790950-3	2015	The PI3K regulatory subunit p85alpha and phosphorylation of Akt on serine 473 (p-Akt S473) are downregulated in sensory hair cells, including both outer and inner hair cells, and supporting cells of the mouse organ of Corti 1 h after exposure to permanent-threshold-shift-inducing noise (PTS noise), but not with temporary-threshold-shift-inducing noise (TTS noise).	Serine	67-73	thymoma viral proto-oncogene 1	Mus musculus	81-84	
25825734-4	2015	Igf2-Akt signaling, in turn, stabilizes full-length Gli2 through Serine 230, thus enhancing the output of transcriptional activation by Hh.	Serine	65-71	thymoma viral proto-oncogene 1	Mus musculus	5-8	
25564616-6	2015	Furthermore, reduced levels of Ser-473-phosphorylated Akt and Ser-253-phosphorylated Foxo3a and elevated pro-apoptotic proteins, Bad, Bax, and cleaved poly ADP-ribose polymerase (PARP), were observed in cKO mice, replicating the signaling alterations in 4-VCD-treated ovaries.	Serine	31-34	thymoma viral proto-oncogene 1	Mus musculus	54-57	
25853295-7	2015	Our findings suggest for the first time that a site-specific phosphorylation at the serine 473 residue of AKT1 modifies the capacity for tumors to disseminate.	Serine	84-90	thymoma viral proto-oncogene 1	Mus musculus	106-110	
25231380-4	2015	Multivariate statistics highlighted consistent metabolic changes in gastrocnemius muscle following Akt1 activation, which included significant reductions of serine and histidine-containing dipeptides (anserine and carnosine), in addition to increased concentrations of phosphorylated sugars.	Serine	157-163	thymoma viral proto-oncogene 1	Mus musculus	99-103	
24488013-4	2015	The effects required Akt-mediated phosphorylation of EphA2 on serine 897.	Serine	62-68	thymoma viral proto-oncogene 1	Mus musculus	21-24	
25997722-9	2015	The levels of p-Akt (Ser 473) and Bcl-2 were significantly increased while Bax and cleaved caspase-3 were decreased by hydrogen treatment on the model of H/R.	Serine	21-24	thymoma viral proto-oncogene 1	Mus musculus	16-19	
25378391-4	2014	Akt modulated the pathway by phosphorylating mevalonate diphosphate decarboxylase (MDD) at Ser(96).	Serine	91-94	thymoma viral proto-oncogene 1	Mus musculus	0-3	
25228694-7	2014	Compared with mono-cultured melanoma, co-cultured melanoma cells had a higher proliferation and phospho-Akt (Ser-473 and Thr-450) expression.	Serine	109-112	thymoma viral proto-oncogene 1	Mus musculus	104-107	
25228694-10	2014	Interestingly, we found that palmitic acid stimulated melanoma cell proliferation, changed the cell cycle distribution, and increased phospho-Akt (Ser-473 and Thr-450) and PI3K but not phospho-PTEN (phosphophosphatase and tensin homolog) expressions.	Serine	147-150	thymoma viral proto-oncogene 1	Mus musculus	142-145	
25074979-6	2014	Inhibiting AKT or preventing SIRT6 phosphorylation by mutating Ser(338) prevented the degradation of SIRT6 mediated by MDM2, suppressed the proliferation of breast cancer cells in culture, and inhibited the growth of breast tumor xenografts in mice.	Serine	63-66	thymoma viral proto-oncogene 1	Mus musculus	11-14	
25264192-4	2014	In mouse osteoblasts, LDI (1Gy) induced phosphorylation of DNA-PKcs and Akt (mainly at Ser-473).	Serine	87-90	thymoma viral proto-oncogene 1	Mus musculus	72-75	
25264192-6	2014	Further, siRNA-knockdown of SIN1, a key component of mTOR complex 2 (mTORC2), also inhibited LDI-induced Akt Ser-473 phosphorylation as well as ALP activity increase and Col I/Runx2 expression in mouse osteoblasts.	Serine	109-112	thymoma viral proto-oncogene 1	Mus musculus	105-108	
25264192-8	2014	In summary, our data suggest that DNA-PKcs-SIN1 complexation-mediated Akt activation (Ser-473 phosphorylation) is required for mouse osteoblast differentiation.	Serine	86-89	thymoma viral proto-oncogene 1	Mus musculus	70-73	
24933620-4	2014	Mutation of cysteines to serines at 296 and 310 in Akt1 did not affect its basal kinase activity but abolished cadmium- and Grx1 downregulation-induced reduction in Akt1 kinase activity, indicating their critical role in redox modulation of Akt1 function and turnover.	Serine	25-32	thymoma viral proto-oncogene 1	Mus musculus	51-55	
24933620-4	2014	Mutation of cysteines to serines at 296 and 310 in Akt1 did not affect its basal kinase activity but abolished cadmium- and Grx1 downregulation-induced reduction in Akt1 kinase activity, indicating their critical role in redox modulation of Akt1 function and turnover.	Serine	25-32	thymoma viral proto-oncogene 1	Mus musculus	165-169	
24933620-4	2014	Mutation of cysteines to serines at 296 and 310 in Akt1 did not affect its basal kinase activity but abolished cadmium- and Grx1 downregulation-induced reduction in Akt1 kinase activity, indicating their critical role in redox modulation of Akt1 function and turnover.	Serine	25-32	thymoma viral proto-oncogene 1	Mus musculus	165-169	
24933620-7	2014	Moreover, preventing oxidative modification of Akt1 cysteines 296 and 310 by mutating them to serines increased the cell survival effects of Akt1.	Serine	94-101	thymoma viral proto-oncogene 1	Mus musculus	47-51	
24933620-7	2014	Moreover, preventing oxidative modification of Akt1 cysteines 296 and 310 by mutating them to serines increased the cell survival effects of Akt1.	Serine	94-101	thymoma viral proto-oncogene 1	Mus musculus	141-145	
25074986-8	2014	Insulin-stimulated serine phosphorylation of Akt and glucose transporter 4 translocation were decreased in the skeletal muscle from MI by 48 and 49% of Sham, both of which were ameliorated in MI+HRP.	Serine	19-25	thymoma viral proto-oncogene 1	Mus musculus	45-48	
24985103-11	2014	At the end of the 2-wk treatment period, SCO- and SAN-treated mice had enhanced insulin-responsive Akt serine-473 phosphorylation and significantly decreased monocyte chemotactic protein-1 levels in visceral WAT compared with control mice; these differences were depot specific.	Serine	103-109	thymoma viral proto-oncogene 1	Mus musculus	99-102	
25057205-5	2014	The serine/threonine kinase Akt, which regulates HTT function, rescued the spindle misorientation caused by the mHTT, by serine 421 (S421) phosphorylation, in cultured cells and in mice.	Serine	4-10	thymoma viral proto-oncogene 1	Mus musculus	28-31	
24629015-8	2014	Skeletal muscle atrophy of infarcted beta2 KO mice was paralleled by reduced levels of phosphorylated Akt at Ser 473 while increased levels of proteins related with the ubiquitin--proteasome system, and increased 26S proteasome activity.	Serine	109-112	thymoma viral proto-oncogene 1	Mus musculus	102-105	
24777252-4	2014	In resting macrophages, CKIP-1 was phosphorylated at Serine 342 by constitutively active GSK3beta, the downstream target of Akt.	Serine	53-59	thymoma viral proto-oncogene 1	Mus musculus	124-127	
24728251-7	2014	There was increase in phosphorylation by protein kinase B/Akt serine, improve in insulin signaling and reduce of fasting glucose in mice that swam for 1 hour without overload and mice that swan for 1 hour with overload of 5%.	Serine	62-68	thymoma viral proto-oncogene 1	Mus musculus	58-61	
24662050-1	2014	The protein kinase Akt plays a critical role in heart function and is activated by phosphorylation of threonine 308 (T308) and serine 473 (S473).	Serine	127-133	thymoma viral proto-oncogene 1	Mus musculus	19-22	
24944899-2	2014	Rictor is a key regulatory/structural subunit of the mTORC2 complex and is required for hydrophobic motif site phosphorylation of Akt at serine 473.	Serine	137-143	thymoma viral proto-oncogene 1	Mus musculus	130-133	
24334165-7	2014	Next, we investigated whether SA4503 affected the phosphorylation levels of Akt (Ser 473) and extracellular signal-regulated kinase (ERK) 1/2 and the expression of the sigma-1 receptor.	Serine	81-84	thymoma viral proto-oncogene 1	Mus musculus	76-79	
24332015-8	2014	IHC of male mice AAA aortas showed increased p308, AKT-Ser-473, and T-AKT compared with female mice.	Serine	55-58	thymoma viral proto-oncogene 1	Mus musculus	51-54	
24299616-5	2014	However, starting at early time points, 1 consistently inhibited the phosphorylation of protein kinase B/Akt at serine 473.	Serine	112-118	thymoma viral proto-oncogene 1	Mus musculus	105-108	
24334165-8	2014	SA4503 promoted the phosphorylation of Akt (Ser 473) and ERK1/2 in a time-dependent manner, but SA4503 did not affect the expression of the sigma-1 receptor.	Serine	44-47	thymoma viral proto-oncogene 1	Mus musculus	39-42	
23188702-5	2013	Here, we show that phosphorylation of Akt occurs at serine 473 (Ser473) in the CA3 region of WT but not D2R-/- mice following KA.	Serine	52-58	thymoma viral proto-oncogene 1	Mus musculus	38-41	
25136373-7	2014	SJW also exerted an insulin-sensitizing effect as indicated by a significant increase in insulin-stimulated Akt serine phosphorylation in epididymal white adipose tissue (P &lt; 0.01).	Serine	112-118	thymoma viral proto-oncogene 1	Mus musculus	108-111	
24391749-5	2013	As well as the stimulation of IRS1 and Akt serine phosphorylation, insulin-stimulated phosphorylation of mTOR and S6K is time-dependent in 3T3-L1 adipocytes, whereas evodiamine does not affect their phosphorylation except for an inhibitory effect on mTOR phosphorylation.	Serine	43-49	thymoma viral proto-oncogene 1	Mus musculus	39-42	
24068707-6	2013	Saccharin-stimulated Akt phosphorylation at Thr-308 occurred within 5 min, was phosphatidylinositol 3-kinase-dependent, and occurred in the presence of high concentrations of insulin and dexamethasone; phosphorylation of Ser-473 occurred more gradually.	Serine	221-224	thymoma viral proto-oncogene 1	Mus musculus	21-24	
23868942-5	2013	Phosphorylation of mTORC2 downstream target Akt at Serine 473 was reduced in PVAT from rictor(ad-/-) mice but unaffected in aortic tissue.	Serine	51-57	thymoma viral proto-oncogene 1	Mus musculus	44-47	
23713790-14	2013	In addition, GYY4137 increased aortic eNOS phosphorylation and expression of PI3K, enhanced Akt Ser(473) phosphorylation and down-regulated the expression of LOX-1.	Serine	96-99	thymoma viral proto-oncogene 1	Mus musculus	92-95	
23762260-2	2013	Here we demonstrate that Akt phosphorylates special AT-rich sequences binding protein 1 (SATB1) at serine 47 and protects SATB1 from apoptotic cleavage.	Serine	99-105	thymoma viral proto-oncogene 1	Mus musculus	25-28	
23361301-7	2013	In colonic epithelial cells, exposure to a PAF analog led to dephosphorylation of Akt at serine-473 and induction of apoptosis.	Serine	89-95	thymoma viral proto-oncogene 1	Mus musculus	82-85	
23435959-4	2013	The present study showed that reverse D-4F (10-100 mug/ml) significantly improved the proliferation, migration, and tube formation of EPCs in a dose-dependent manner, and activated phospho-AKT at serine residue 473 and phospho-eNOS at serine residue 1177.	Serine	196-202	thymoma viral proto-oncogene 1	Mus musculus	189-192	
23435959-4	2013	The present study showed that reverse D-4F (10-100 mug/ml) significantly improved the proliferation, migration, and tube formation of EPCs in a dose-dependent manner, and activated phospho-AKT at serine residue 473 and phospho-eNOS at serine residue 1177.	Serine	235-241	thymoma viral proto-oncogene 1	Mus musculus	189-192	
23369342-10	2013	Meanwhile, 6-gingerol diminished the insulin-stimulated serine phosphorylation of Akt (Ser473) and GSK3beta (Ser9).	Serine	56-62	thymoma viral proto-oncogene 1	Mus musculus	82-85	
23462102-5	2013	At later developmental stages, the abundance of the kinase Akt increased, resulting in the binding of Akt to Dock6 and the phosphorylation of Dock6 at Ser(1194).	Serine	151-154	thymoma viral proto-oncogene 1	Mus musculus	59-62	
23359699-4	2013	Increasing the cellular ratio of 20:4-PC by supplementation of 20:4-PC to the cell culture medium diminished Akt [serine (Ser)473] phosphorylation.	Serine	114-120	thymoma viral proto-oncogene 1	Mus musculus	109-112	
23359699-4	2013	Increasing the cellular ratio of 20:4-PC by supplementation of 20:4-PC to the cell culture medium diminished Akt [serine (Ser)473] phosphorylation.	Serine	122-125	thymoma viral proto-oncogene 1	Mus musculus	109-112	
24260338-10	2013	Reduced expression of phosphorylated MAPKAP-2, ERK, and Akt (ser(473) &amp; thr(308)) were noticed.	Serine	61-64	thymoma viral proto-oncogene 1	Mus musculus	56-59	
23748360-4	2013	Palmitate-induced mtDNA damage, mtROS, mitochondrial dysfunction, and activation of JNK were all diminished, whereas ATP levels, mitochondrial mass, insulin-stimulated phosphorylation of Akt (Ser 473), and insulin sensitivity were increased in primary myotubes isolated from Tg/MTS-hOGG1 mice compared to myotubes isolated from either knockout or wild-type mice.	Serine	192-195	thymoma viral proto-oncogene 1	Mus musculus	187-190	
23512198-7	2013	Protein kinase AKT-mediated phosphorylation of Rac1 at serine(71) was essential for FBXL19-mediated Rac1 ubiquitination and depletion.	Serine	55-61	thymoma viral proto-oncogene 1	Mus musculus	15-18	
23504323-3	2013	Protein suppression using specific siRNAs revealed that heparanase-induced phosphorylation of AKT at Ser-473 was RICTOR-mTOR-dependent, whereas ILK and PAK1/2 were dispensable.	Serine	101-104	thymoma viral proto-oncogene 1	Mus musculus	94-97	
23593332-8	2013	DHEA treatment also significantly increased phosphorylation of Akt (Ser-473), Akt (Ser-308) and ERK in the DG.	Serine	68-71	thymoma viral proto-oncogene 1	Mus musculus	63-66	
23593332-8	2013	DHEA treatment also significantly increased phosphorylation of Akt (Ser-473), Akt (Ser-308) and ERK in the DG.	Serine	83-86	thymoma viral proto-oncogene 1	Mus musculus	78-81	
23593332-9	2013	Furthermore, GSK-3beta (Ser-9) phosphorylation increased in the DG of OBX mice possibly accounting for increased neurogenesis through Akt activation.	Serine	24-27	thymoma viral proto-oncogene 1	Mus musculus	134-137	
23340653-11	2013	NF-kappaB activation was reduced but phospho-(Ser/Ther) Akt substrate expression was increased in corneas after irradiation when treated with GGA.	Serine	46-49	thymoma viral proto-oncogene 1	Mus musculus	56-59	
23204326-2	2013	One potential mechanism is PI3K- and Akt-mediated activation of mechanistic target of rapamycin (mTOR) and ribosomal protein S6 kinase (S6K), which may impair insulin-mediated activation of insulin receptor substrate (IRS)1/2 via inhibitory serine phosphorylation or proteasomal degradation.	Serine	241-247	thymoma viral proto-oncogene 1	Mus musculus	37-40	
22936801-7	2012	In addition, ASPP 049 induced phosphorylations at serine 473 of Akt and serine 9 of GSK-3beta.	Serine	50-56	thymoma viral proto-oncogene 1	Mus musculus	64-67	
23308182-7	2013	Akt sites on Clk1 are in the serine/arginine-rich domain and not the kinase domain.	Serine	29-35	thymoma viral proto-oncogene 1	Mus musculus	0-3	
23181282-9	2012	The results suggest that ASX treatment promotes the IRS-PI3K-Akt pathway of insulin signaling by decreasing serine phosphorylation of IRS proteins, and improves glucose metabolism by modulating metabolic enzymes.	Serine	108-114	thymoma viral proto-oncogene 1	Mus musculus	61-64	
23100026-3	2012	The ability of insulin to promote Akt phosphorylation on Ser(473) was significantly lower in extensor digitorum longus (EDL) and soleus muscles from Akt1(-/-) and Akt2(-/-) mice compared with WT mice.	Serine	57-60	thymoma viral proto-oncogene 1	Mus musculus	34-37	
22910893-4	2012	We assessed cerebral blood flow up to 6 hours, neurological deficits, injury size, and phosphorylation of Akt (Serine(473)) as a prosurvival signal in the ischemic hemisphere at 48 hours poststroke.	Serine	111-117	thymoma viral proto-oncogene 1	Mus musculus	106-109	
22773877-6	2012	Lrictor(KO) mice had defects in insulin-stimulated Akt Ser-473 and Thr-308 phosphorylation, leading to decreased phosphorylation of Akt substrates FoxO, GSK-3beta, PRAS40, AS160, and Tsc2.	Serine	55-58	thymoma viral proto-oncogene 1	Mus musculus	51-54	
22814108-5	2012	Experiments were performed in mutant mice in which Akt/SGK-dependent GSK3alpha,beta inhibition was disrupted by replacement of the serine residue in the respective SGK/Akt-phosphorylation consensus sequence by alanine (gsk3(KI)).	Serine	131-137	thymoma viral proto-oncogene 1	Mus musculus	51-54	
22753193-7	2012	VEGFR-1 knockout led to abundant accumulation of VEGFR-2 at the protein level, increased VEGFR-2 tyrosine phosphorylation transiently, and enhanced serine phosphorylation of Akt and ERK.	Serine	148-154	thymoma viral proto-oncogene 1	Mus musculus	174-177	
22471389-8	2012	Interestingly, CAF diminished the insulin-stimulated serine phosphorylation of Akt (Ser473) and GSK3beta (Ser9), which may reduce glucose uptake in response to insulin and lipid accumulation.	Serine	53-59	thymoma viral proto-oncogene 1	Mus musculus	79-82	
22581458-6	2012	These protective effects of the GRK2 inhibitor may be attributable to the augmented Akt/eNOS pathway activation (as evidenced by increases in Akt phosphorylation at Ser(473) and at Thr(308), and eNOS phosphorylation at Ser(1177)) and to the prevention of the GRK2 translocation and promotion of beta-arrestin 2 translocation to the membrane under clonidine stimulation.	Serine	165-168	thymoma viral proto-oncogene 1	Mus musculus	84-87	
22581458-6	2012	These protective effects of the GRK2 inhibitor may be attributable to the augmented Akt/eNOS pathway activation (as evidenced by increases in Akt phosphorylation at Ser(473) and at Thr(308), and eNOS phosphorylation at Ser(1177)) and to the prevention of the GRK2 translocation and promotion of beta-arrestin 2 translocation to the membrane under clonidine stimulation.	Serine	165-168	thymoma viral proto-oncogene 1	Mus musculus	142-145	
22581458-6	2012	These protective effects of the GRK2 inhibitor may be attributable to the augmented Akt/eNOS pathway activation (as evidenced by increases in Akt phosphorylation at Ser(473) and at Thr(308), and eNOS phosphorylation at Ser(1177)) and to the prevention of the GRK2 translocation and promotion of beta-arrestin 2 translocation to the membrane under clonidine stimulation.	Serine	219-222	thymoma viral proto-oncogene 1	Mus musculus	84-87	
21938726-4	2012	Here, we demonstrated that chronic exercise increased the basal levels and insulin-induced Akt serine phosphorylation in the liver of diet-induced obese mice.	Serine	95-101	thymoma viral proto-oncogene 1	Mus musculus	91-94	
21978520-3	2012	RESULTS: A single session of inescapable shocks (IES) in mice reduced FoxO3a phosphorylation at the Akt-regulating serine/threonine residues and induced prolonged nuclear accumulation of FoxO3a in the cerebral cortex, both indicating activation of FoxO3a in brain.	Serine	115-121	thymoma viral proto-oncogene 1	Mus musculus	100-103	
22792172-11	2012	Phosphatidylinositol 3-kinase (PI3K) activity and Akt-Ser(473) phosphorylation were both increased by IGFBP-3 and selectively blocked by the SRB1-Ab or PI3K blocker LY294002.	Serine	54-57	thymoma viral proto-oncogene 1	Mus musculus	50-53	
22184110-7	2012	Furthermore, kinase-dead mTOR increased and decreased phosphorylation of Akt at catalytic loop site Thr-308 and hydrophobic motif site Ser-473, respectively.	Serine	135-138	thymoma viral proto-oncogene 1	Mus musculus	73-76	
22064483-2	2012	In murine embryonic stem cells (mESCs), Gsk3beta is inhibited by multiple mechanisms, including its inhibitory phosphorylation on serine 9 by protein kinase B (Akt), a major effector of the canonical phosphatidylinositol 3-kinase (PI3K) pathway.	Serine	130-136	thymoma viral proto-oncogene 1	Mus musculus	160-163	
22984593-8	2012	The phosphorylation of AKT and p65 at serine 536 but not serine 468 was enhanced obviously by NCTD in a dose dependent manner, whereas the degradation of IkappaBalpha was little effected.	Serine	38-44	thymoma viral proto-oncogene 1	Mus musculus	23-26	
22764594-5	2012	Damp weights of the musculus soleus, plantaris, gastrocnemius, extensor digitorum longus and tibialis anterior were measured, and Western blot was used to measure the expression levels of pAkt (ser 473), pAkt(Thr 308), total Akt and caspase-3 proteins in the aforementioned skeleton muscles.	Serine	194-197	thymoma viral proto-oncogene 1	Mus musculus	189-192	
23419399-9	2012	Coffee ingestion significantly increased the insulin-induced serine phosphorylation of Akt in liver and skeletal muscle, but not in epididymal fat, of KK-A(y) mice.	Serine	61-67	thymoma viral proto-oncogene 1	Mus musculus	87-90	
21712384-8	2011	In contrast, SODD(-/-) mouse embryonic fibroblasts exhibit reduced Akt-Ser(473) and -Thr(308) phosphorylation following EGF stimulation, associated with increased SKIP PI(3,4,5)P(3)-5-ptase activity.	Serine	71-74	thymoma viral proto-oncogene 1	Mus musculus	67-70	
21922189-3	2011	PI3/PKB/Akt/SGK-dependent inhibition of GSK3 is disrupted in gene-targeted knockin mice with mutated and thus PKB/SGK-resistant GSK3alpha,ss (gsk3                         (                            KI                         )) where the serine of the PKB/SGK phosphorylation site has been replaced by alanine.	Serine	240-246	thymoma viral proto-oncogene 1	Mus musculus	4-7	
21922189-3	2011	PI3/PKB/Akt/SGK-dependent inhibition of GSK3 is disrupted in gene-targeted knockin mice with mutated and thus PKB/SGK-resistant GSK3alpha,ss (gsk3                         (                            KI                         )) where the serine of the PKB/SGK phosphorylation site has been replaced by alanine.	Serine	240-246	thymoma viral proto-oncogene 1	Mus musculus	8-11	
21922189-3	2011	PI3/PKB/Akt/SGK-dependent inhibition of GSK3 is disrupted in gene-targeted knockin mice with mutated and thus PKB/SGK-resistant GSK3alpha,ss (gsk3                         (                            KI                         )) where the serine of the PKB/SGK phosphorylation site has been replaced by alanine.	Serine	240-246	thymoma viral proto-oncogene 1	Mus musculus	110-113	
21922189-3	2011	PI3/PKB/Akt/SGK-dependent inhibition of GSK3 is disrupted in gene-targeted knockin mice with mutated and thus PKB/SGK-resistant GSK3alpha,ss (gsk3                         (                            KI                         )) where the serine of the PKB/SGK phosphorylation site has been replaced by alanine.	Serine	240-246	thymoma viral proto-oncogene 1	Mus musculus	110-113	
22412835-5	2012	In the presence of CD152 signaling, the chemoattractant CCL4 selectively induces the full activation of Akt via phosphorylation at threonine 308 and serine 473 in pro-inflammatory Th lymphocytes expressing the cognate chemokine receptor CCR5.	Serine	149-155	thymoma viral proto-oncogene 1	Mus musculus	104-107	
21666107-8	2011	Immunoblot analysis data revealed that the levels of both phospho-AMP-activated protein kinase (Thr(172)) and phospho-Akt (Ser(473)) were significantly upregulated when RGZ was administered 5 min before reperfusion compared with vehicle.	Serine	123-126	thymoma viral proto-oncogene 1	Mus musculus	118-121	
21551011-3	2011	PKB activity, as assessed by Thr(308) and Ser(473) phosphorylation, was significantly higher in EDL and SOL muscles from AG than MA mice.	Serine	42-45	thymoma viral proto-oncogene 1	Mus musculus	0-3	
21737686-4	2011	In vitro and in vivo studies confirmed that Akt phosphorylates Ankrd2 at Ser-99.	Serine	73-76	thymoma viral proto-oncogene 1	Mus musculus	44-47	
21737686-8	2011	Moreover, the forced expression of a phosphorylation-defective mutant form of Ankrd2 in C(2)C(12) myoblasts promoted a faster differentiation program, implicating Akt-dependent phosphorylation at Ser-99 in the negative regulation of myogenesis in response to stress conditions.	Serine	196-199	thymoma viral proto-oncogene 1	Mus musculus	163-166	
21385608-5	2011	Procaterol induced eNOS phosphorylation at Ser(1177), which was prevented by PTX, PP2 or Akt inhibitor.	Serine	43-46	thymoma viral proto-oncogene 1	Mus musculus	89-92	
21385608-9	2011	To conclude, the mouse pulmonary endothelial beta2-AR is coupled to a G(i/o)-Src kinase-PI3K/Akt pathway to promote eNOS phosphorylation at Ser(1177) leading to a NO-dependent vasorelaxation.	Serine	140-143	thymoma viral proto-oncogene 1	Mus musculus	93-96	
21460185-5	2011	Akt feeds back and phosphorylates PIKE-A on Ser-472 and subsequently enhances its stimulatory effect on Akt kinase activity.	Serine	44-47	thymoma viral proto-oncogene 1	Mus musculus	0-3	
21460185-5	2011	Akt feeds back and phosphorylates PIKE-A on Ser-472 and subsequently enhances its stimulatory effect on Akt kinase activity.	Serine	44-47	thymoma viral proto-oncogene 1	Mus musculus	104-107	
21270764-8	2011	ATP depletion in vitro caused greater mitochondrial Bax accumulation and death in primary proximal tubule cells harvested from knockout compared with wild-type mice and altered serine phosphorylation of a Bax peptide at the Akt-specific target site.	Serine	177-183	thymoma viral proto-oncogene 1	Mus musculus	224-227	
21335475-9	2011	Insulin-stimulated serine phosphorylation of Akt and glucose transporter-4 translocation were decreased in MI mice by 61 and 23%, respectively.	Serine	19-25	thymoma viral proto-oncogene 1	Mus musculus	45-48	
21360043-13	2011	PIO similarly increased myocardial Ser-473 P-Akt, cPLA(2), and COX-2 levels after hypoxia/reoxygenation in cells with and without intact PPAR-gamma.	Serine	35-38	thymoma viral proto-oncogene 1	Mus musculus	45-48	
21143412-7	2011	eNOS phosphorylation on Ser-1177 (positive regulatory site) and Thr-495 (negative regulatory site), total eNOS, and phosphorylated AKT (upstream mediator of eNOS phosphorylation on Ser-1177) expressions, and eNOS interactions with heat-shock protein 90 (HSP90) and caveolin-1 were measured by Western blot.	Serine	181-184	thymoma viral proto-oncogene 1	Mus musculus	131-134	
21209093-9	2011	Both PKA and AKT inhibitors attenuated AMPK Ser(485/491) phosphorylation resulting from alpha-adrenergic blockade and prevented decreases in AMPK activity.	Serine	44-47	thymoma viral proto-oncogene 1	Mus musculus	13-16	
21106850-5	2011	In vitro kinase assays combined with reversed-phase liquid chromatography mass spectrometry analysis showed that TBK1 enhanced phosphorylation of Akt on Ser(473), whereas knockdown of TBK1 expression by short interfering RNA in macrophages decreased poly(I:C)- and LPS-induced Akt phosphorylation.	Serine	153-156	thymoma viral proto-oncogene 1	Mus musculus	146-149	
21850156-7	2011	The decrease in Akt phosphorylation is likely caused by increased insulin receptor substrate-1 serine 307 (IRS-1(Ser307)) phosphorylation, which is inhibitory to IGF-1 receptor signaling.	Serine	95-101	thymoma viral proto-oncogene 1	Mus musculus	16-19	
20841468-2	2010	Phosphorylation of MDM2 on Ser(166) and Ser(186) by the survival kinase Akt inhibits p53-mediated apoptosis.	Serine	40-43	thymoma viral proto-oncogene 1	Mus musculus	72-75	
20847051-8	2010	We further demonstrated that SIRT6 negatively regulates AKT phosphorylation at Ser-473 and Thr-308 through inhibition of multiple upstream molecules, including insulin receptor, IRS1, and IRS2.	Serine	79-82	thymoma viral proto-oncogene 1	Mus musculus	56-59	
20813836-6	2010	Additionally, we show for the first time that although palmitate increases IRS-1 serine 307 phosphorylation in 3T3L1 adipocytes, AKT serine 473 phosphorylation is enhanced, not reduced, by palmitate.	Serine	133-139	thymoma viral proto-oncogene 1	Mus musculus	129-132	
20841468-2	2010	Phosphorylation of MDM2 on Ser(166) and Ser(186) by the survival kinase Akt inhibits p53-mediated apoptosis.	Serine	27-30	thymoma viral proto-oncogene 1	Mus musculus	72-75	
20638193-8	2010	Combination treatment mediated radiosensitization by selectively blocking the phosphorylation of the prosurvival protein Akt at serine 473, a process that is independent of DNA-dependent protein kinase catalytic subunit.	Serine	128-134	thymoma viral proto-oncogene 1	Mus musculus	121-124	
20600027-9	2010	Site-directed mutagenesis was employed to replace the serine residue of the consensus Akt substrate motifs of DLC1 with alanine.	Serine	54-60	thymoma viral proto-oncogene 1	Mus musculus	86-89	
20153289-4	2010	Phosphorylation of serine and threonine residues on insulin receptor, insulin receptor substrates (IRS1 and IRS2), and on Akt has been shown to be the major step in insulin signaling that is altered due to the lack of SCD1.	Serine	19-25	thymoma viral proto-oncogene 1	Mus musculus	122-125	
20837912-6	2010	In keeping with a vascular protective effect, adropin stimulated Akt Ser(473) and endothelial nitric oxide (NO) synthase Ser(1177) phosphorylation.	Serine	69-72	thymoma viral proto-oncogene 1	Mus musculus	65-68	
20501873-7	2010	These changes were accompanied by slight reductions in specific p44/42 MAPK activity (-18% on day 72) and, surprisingly, by increased levels of phosphorylated Akt (Ser(473)) (+25% on day 30, +66% on day 72).	Serine	164-167	thymoma viral proto-oncogene 1	Mus musculus	159-162	
20362052-7	2010	Interestingly, stretch and PGE(2) each significantly reduced H(2)O(2)-mediated AKT phosphorylation and was reversed by pretreatment with orthovanadate while stretch alone reduced GSK-3beta inhibitory phosphorylation at ser-9.	Serine	219-222	thymoma viral proto-oncogene 1	Mus musculus	79-82	
20069552-3	2010	Phosphoprotein multiplex assay on lysates from muscle preparation was performed to detect phosphorylation of insulin-receptor on Tyr(1146), Akt on Ser(473) and glycogen-synthases-kinase-3 on Ser(21)/Ser(9).	Serine	147-150	thymoma viral proto-oncogene 1	Mus musculus	140-143	
19609947-7	2009	The phosphorylation of the p65 subunit of NFkappaB at serine 534 is also upregulated in Akt-transformed cells.	Serine	54-60	thymoma viral proto-oncogene 1	Mus musculus	88-91	
19921501-8	2010	Western blot analysis showed that the active form of caspase-3 was also down-regulated after TTC treatment and survival signals, such as the significant phosphorylation of serine/threonine protein kinase Akt, were also detected.	Serine	172-178	thymoma viral proto-oncogene 1	Mus musculus	204-207	
19751099-4	2010	In contrast, serine p-Akt levels increased significantly in homogenates at 6 h post-injury.	Serine	13-19	thymoma viral proto-oncogene 1	Mus musculus	22-25	
20158985-5	2010	Ser-473-phosphorylated Akt was localized uniformly to the meiotic spindle in more than 90% of oocytes.	Serine	0-3	thymoma viral proto-oncogene 1	Mus musculus	23-26	
19710241-8	2009	Inhibition of either the AKT or STAT3 pathway potentiated H2O2-induced cell death and increased GSK-3beta activity by dephosphorylation at serine 9.	Serine	139-145	thymoma viral proto-oncogene 1	Mus musculus	25-28	
20042390-4	2009	Prosaposin pro-tein was proved to activate the PI3K/Akt signal pathway, upregulate the phosphorylative activity of Akt at Serine 473, downregulate the expression of P27(Kip1) gene, upregulate the expression of Cyclin D1 gene and then promote the G1/S tran-sition, and upregulate the expression of survival genes cIAP1 and cIAP2 and then prevent cell apoptosis.	Serine	122-128	thymoma viral proto-oncogene 1	Mus musculus	115-118	
19844585-6	2009	At high H(2)O(2), Akt1-PDK1 association is disrupted and P-Akt1 Ser(473) accumulates in mitochondria in detriment to nuclear translocation; accordingly, Akt1 T308A is retained in mitochondria.	Serine	64-67	thymoma viral proto-oncogene 1	Mus musculus	59-63	
19682597-3	2009	Further, basal phosphorylation of Akt (p-Akt (Ser-473)/total Akt) and GSK-3beta (GSK-3beta (Ser-9)/total GSK-3beta) are reduced 60-70% in primary myotubes from eNOS(-/-) mice.	Serine	46-49	thymoma viral proto-oncogene 1	Mus musculus	34-37	
19844585-2	2009	Akt is differentially activated by growth factors and oxidative stress by sequential phosphorylation of Ser(473) by mTORC2 and Thr(308) by PDK1.	Serine	104-107	thymoma viral proto-oncogene 1	Mus musculus	0-3	
19844585-4	2009	We demonstrate that modulation by H(2)O(2) entails the entrance of cytosolic P-Akt1 Ser(473) to mitochondria, where it is further phosphorylated at Thr(308) by constitutive PDK1.	Serine	84-87	thymoma viral proto-oncogene 1	Mus musculus	79-83	
19844585-6	2009	At high H(2)O(2), Akt1-PDK1 association is disrupted and P-Akt1 Ser(473) accumulates in mitochondria in detriment to nuclear translocation; accordingly, Akt1 T308A is retained in mitochondria.	Serine	64-67	thymoma viral proto-oncogene 1	Mus musculus	59-63	
19434632-8	2009	In the polyps from the treated mice, phosphorylation of ribosomal p70 S6 kinase was maintained, while the phosphorylation of AKT at serine-473 was elevated, suggesting that mTORC1 function is maintained at this dosage.	Serine	132-138	thymoma viral proto-oncogene 1	Mus musculus	125-128	
19570880-10	2009	ATP significantly stimulated Akt1 phosphorylation at Ser(473) by 91 +/- 13%, whereas Akt2 phosphorylation remained unchanged and Akt3 phosphorylation decreased.	Serine	53-56	thymoma viral proto-oncogene 1	Mus musculus	29-33	
19724678-2	2009	Here, we report that long-term exposure to ultraviolet (UV) radiation resulted in enhancement of the levels of cell survival kinases, such as phosphatidylinositol 3-kinase (PI3K), Akt (Ser(473)), p-ERK1/2, and p-p38 in the skin of IL-12p40 knockout (IL-12 KO) mice compared with the skin of wild-type mice.	Serine	185-188	thymoma viral proto-oncogene 1	Mus musculus	180-183	
19013131-3	2009	The serine/threonine kinase Akt is a critical cell signaling to neuronal survival.	Serine	4-10	thymoma viral proto-oncogene 1	Mus musculus	28-31	
19403525-8	2009	In mice, high fat diet-induced diabetes was associated with aortic PTEN up-regulation, PTEN-Ser(380)/Thr(382/383) phosphorylation, and dephosphorylation of both Akt (at Ser(473)) and eNOS (at Ser(1177)).	Serine	169-172	thymoma viral proto-oncogene 1	Mus musculus	161-164	
19403525-8	2009	In mice, high fat diet-induced diabetes was associated with aortic PTEN up-regulation, PTEN-Ser(380)/Thr(382/383) phosphorylation, and dephosphorylation of both Akt (at Ser(473)) and eNOS (at Ser(1177)).	Serine	169-172	thymoma viral proto-oncogene 1	Mus musculus	161-164	
19497867-2	2009	mTORC2, which consists of rictor, mSIN1, mLST8, and mTOR, is activated by insulin/IGF1 and phosphorylates Ser-473 in the hydrophobic motif of Akt/PKB.	Serine	106-109	thymoma viral proto-oncogene 1	Mus musculus	142-149	
19406993-8	2009	Since Akt phosphorylates Chk1-Ser(280), the effect of Erbb2 on phosphatidyl inositol-3-kinase (PI3K)/Akt signaling during UV-induced cell cycle arrest was determined.	Serine	30-33	thymoma viral proto-oncogene 1	Mus musculus	6-9	
19289601-5	2009	LPS-induced phosphorylation of Akt serine 473 was blunted in MyD88(-/-) macrophages and was completely TLR4-dependent.	Serine	35-41	thymoma viral proto-oncogene 1	Mus musculus	31-34	
19064993-6	2009	The reduction in skeletal muscle insulin responsiveness occurred without any change in GLUT4 protein expression levels but was associated with an impairment of the insulin-stimulated protein kinase B/Akt serine 473 phosphorylation but not threonine 308.	Serine	204-210	thymoma viral proto-oncogene 1	Mus musculus	200-203	
18923161-8	2009	MDM2 activation is accompanied by phosphorylation of Ser-166, and this is commonly catalyzed by the phosphatidylinositol-3 kinase and RAC-alpha serine/threonine-protein kinase (AKT) signaling pathway.	Serine	53-56	thymoma viral proto-oncogene 1	Mus musculus	177-180	
19630168-8	2009	MDM2 activation is accompanied by phosphorylation of Ser-166, and this is commonly catalyzed by the phosphatidylinositol-3 kinase and RAC-alpha serine/threonine-protein kinase (AKT) signaling pathway.	Serine	53-56	thymoma viral proto-oncogene 1	Mus musculus	177-180	
19359162-9	2009	OSU-03012 induced apoptosis in both VS and HMS-97 cells and caused a marked reduction of AKT phosphorylation at both the Ser-308 and Thr-473 sites in a dose-dependent manner.	Serine	121-124	thymoma viral proto-oncogene 1	Mus musculus	89-92	
19066318-7	2009	Insulin-induced glucose uptake and Akt Ser(473) phosphorylation was blocked by hypoxia in the adipocytes.	Serine	39-42	thymoma viral proto-oncogene 1	Mus musculus	35-38	
18757368-5	2008	To address this, we analyzed basal, insulin-induced, and DNA damage-induced PKB Ser-473 phosphorylation in DNA-PK catalytic subunit-null DNA-PKcs(-/-) mice.	Serine	80-83	thymoma viral proto-oncogene 1	Mus musculus	76-79	
19365570-13	2009	While Akt Ser 473 phosphorylation was readily detectable in AND-34(+/+) lens epithelial cells, it was markedly reduced in the AND-34(-/-) lens epithelium.	Serine	10-13	thymoma viral proto-oncogene 1	Mus musculus	6-9	
18757368-1	2008	Full activation of protein kinase B (PKB/Akt) requires phosphorylation on Thr-308 and Ser-473.	Serine	86-89	thymoma viral proto-oncogene 1	Mus musculus	19-35	
18757368-1	2008	Full activation of protein kinase B (PKB/Akt) requires phosphorylation on Thr-308 and Ser-473.	Serine	86-89	thymoma viral proto-oncogene 1	Mus musculus	37-40	
18757368-1	2008	Full activation of protein kinase B (PKB/Akt) requires phosphorylation on Thr-308 and Ser-473.	Serine	86-89	thymoma viral proto-oncogene 1	Mus musculus	41-44	
20429421-4	2009	FOXO1 is phosphorylated on three sites (Thr-24, Ser-256 and Ser-319) in phosphatidylinositol 3-kinase (PI3-K)/Akt-dependenr manner, thereby inhibiting apoptosis signals.	Serine	48-51	thymoma viral proto-oncogene 1	Mus musculus	110-113	
20429421-4	2009	FOXO1 is phosphorylated on three sites (Thr-24, Ser-256 and Ser-319) in phosphatidylinositol 3-kinase (PI3-K)/Akt-dependenr manner, thereby inhibiting apoptosis signals.	Serine	60-63	thymoma viral proto-oncogene 1	Mus musculus	110-113	
18987114-3	2009	PKB/SGK-dependent GSK regulation is disrupted in mice carrying a mutation, in which the serine in the SGK/PKB-phosphorylation consensus sequence is replaced by alanine.	Serine	88-94	thymoma viral proto-oncogene 1	Mus musculus	0-3	
18987114-3	2009	PKB/SGK-dependent GSK regulation is disrupted in mice carrying a mutation, in which the serine in the SGK/PKB-phosphorylation consensus sequence is replaced by alanine.	Serine	88-94	thymoma viral proto-oncogene 1	Mus musculus	106-109	
18718531-10	2008	Moreover, JNK inhibition impairs leptin-stimulated Ser-473 phosphorylation of Akt that is required for its activation.	Serine	51-54	thymoma viral proto-oncogene 1	Mus musculus	78-81	
18721797-3	2008	Here, we determined that p-Ser(473)-PKB/Akt but not p-Thr(308)-PKB/Akt phosphorylation is highly temperature sensitive.	Serine	27-30	thymoma viral proto-oncogene 1	Mus musculus	40-43	
18721797-4	2008	p-Ser(473)-PKB/Akt phosphorylation was rapidly reduced to levels below 50% on exposure to 20-25 degrees C in murine and human cell lines including cells expressing constitutively active PI3K or lacking PTEN.	Serine	2-5	thymoma viral proto-oncogene 1	Mus musculus	15-18	
18369660-3	2008	Replacement of the serines in the PKB/SGK consensus sequences by alanine (gsk3 ( KI )) confers resistance of GSK3 to PKB/SGK.	Serine	19-26	thymoma viral proto-oncogene 1	Mus musculus	34-37	
18369660-3	2008	Replacement of the serines in the PKB/SGK consensus sequences by alanine (gsk3 ( KI )) confers resistance of GSK3 to PKB/SGK.	Serine	19-26	thymoma viral proto-oncogene 1	Mus musculus	117-120	
18413778-7	2008	Akt (Ser(473)) phosphorylation, Akt kinase activity, and phosphorylation of downstream targets of Akt in prostates were significantly reduced in the LF diet group compared with the HF group.	Serine	5-8	thymoma viral proto-oncogene 1	Mus musculus	0-3	
18701476-7	2008	The repression of Oct4 reduces Tcl1 expression and further down-regulates the level of p-Ser.473-Akt1.	Serine	89-92	thymoma viral proto-oncogene 1	Mus musculus	97-101	
18391484-7	2008	The expression levels of both total Akt protein and clonidine-induced Ser-473-phosphorylated Akt were significantly decreased in diabetic aortas, while chronic simvastatin administration improved these decreased levels.	Serine	70-73	thymoma viral proto-oncogene 1	Mus musculus	93-96	
17974583-10	2008	Significant increases of approximately 100% and approximately 200% in Akt (Ser-473) and p70(s6k) (Thr-389) phosphorylation were measured in overloaded plantaris from both WT and MKR mice, respectively.	Serine	75-78	thymoma viral proto-oncogene 1	Mus musculus	70-73	
18086904-8	2008	Analysis of intracellular signaling in muscle resistance arteries showed that PKC theta activation reduced insulin-mediated Akt phosphorylation (Ser(473)) and increased extracellular signal-related kinase (ERK) 1/2 phosphorylation.	Serine	145-148	thymoma viral proto-oncogene 1	Mus musculus	124-127	
18209096-3	2008	Coculture with T cells induced phosphorylation of Akt (Ser(473)) and its downstream mediators, GSK-3alpha/GSK-beta, FoxO1/3a, and mouse double minute-2, and enhanced FLS proliferation.	Serine	55-58	thymoma viral proto-oncogene 1	Mus musculus	50-53	
18042541-2	2008	Phosphorylation of Akt at regulatory residues Thr-308 and Ser-473 leads to its full activation.	Serine	58-61	thymoma viral proto-oncogene 1	Mus musculus	19-22	
17460049-3	2007	Akt1 deficiency delayed tumor growth and reduced lung metastases, correlating with a reduction in phosphorylation of the Akt1 target, tuberous sclerosis 2 (TSC2) at Ser-939.	Serine	165-168	thymoma viral proto-oncogene 1	Mus musculus	0-4	
20936097-7	2008	The survival protein kinase B (PKB/Akt) displayed a 2-fold increase in phosphorylation at its Ser-473 activation site following CG stimulation.	Serine	94-97	thymoma viral proto-oncogene 1	Mus musculus	31-34	
20936097-7	2008	The survival protein kinase B (PKB/Akt) displayed a 2-fold increase in phosphorylation at its Ser-473 activation site following CG stimulation.	Serine	94-97	thymoma viral proto-oncogene 1	Mus musculus	35-38	
20936097-10	2008	Our findings revealed that there may be a PI3K-independent pathway which also mediated Akt Ser-473 phosphorylation.	Serine	91-94	thymoma viral proto-oncogene 1	Mus musculus	87-90	
17634444-8	2007	Paf induced increased accumulation of serine 473-phosphorylated AKT in the region of the plasma membrane, consistent with its recruitment to membrane PIP3.	Serine	38-44	thymoma viral proto-oncogene 1	Mus musculus	64-67	
17584959-12	2007	Insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1 and serine phosphorylation of Akt/Akt2 in soleus muscle was markedly impaired in HFD-fed mice but reversed by L-NAME treatment.	Serine	80-86	thymoma viral proto-oncogene 1	Mus musculus	106-109	
17616749-10	2007	U0126 blocked the ATV induction of Ser(473) P-Akt and Thr(308) P-Akt while attenuating the induction of P-eNOS.	Serine	35-38	thymoma viral proto-oncogene 1	Mus musculus	46-49	
17629407-7	2007	VO(OPT) treatment inhibited reduced Akt phosphorylation at Ser-473 following brain ischemia and restored decreased phosphorylation of forkhead box class O (FOXO) family members such as FKHR, FKHRL1, and AFX.	Serine	59-62	thymoma viral proto-oncogene 1	Mus musculus	36-39	
17924178-6	2007	Basal and apelin-induced phosphorylation of Akt (at both the threonine 308 and serine 473 phosphorylation sites) and p44/42 during the reperfusion phase was determined by Western blotting and Akt activity measured using an Enzyme-Linked ImmunoSorbent Assay (ELISA).	Serine	79-85	thymoma viral proto-oncogene 1	Mus musculus	44-47	
18058367-9	2007	At 10 days after BIBX1382BS treatment, FaDu transfectants, in contrast to fibroblasts, showed reduced cell size, accumulation of G1 phase cells and reduced Akt-serine(S)473 phosphorylation.	Serine	160-166	thymoma viral proto-oncogene 1	Mus musculus	156-159	
17322282-7	2007	In these lungs, tyrosine phosphorylation of beta-catenin and serine/threonine phosphorylation of Akt, glycogen synthase kinase 3beta (GSK3beta), and ERK1/2 increased significantly with peak effects at 60 min.	Serine	61-67	thymoma viral proto-oncogene 1	Mus musculus	97-100	
17359956-8	2007	Finally, in db/db mice, considerable increases in phosphorylation of Akt on serine 473 and of eNOS on serine 1177 were found in aortas pretreated with apelin.	Serine	76-82	thymoma viral proto-oncogene 1	Mus musculus	69-72	
17409645-5	2007	Potential activation was measured by phosphorylation of Akt at Ser(473), Bad at Ser(136), FKHR at Ser(256), and FKHRL1 at Thr(32) using Western blot analysis.	Serine	63-66	thymoma viral proto-oncogene 1	Mus musculus	56-59	
17210832-9	2007	Moreover, the increase in the amount of Ser(473)-phosphorylated Akt, a stimulator of cardiac hypertrophy, was lower in the group lacking the Dvl-1 gene.	Serine	40-43	thymoma viral proto-oncogene 1	Mus musculus	64-67	
16982679-4	2006	Expression of myr-Akt1 in the salivary glands results in a significant reduction in phosphorylation of p53 at serine(18), total p53 protein accumulation, and p21(WAF1) or Bax mRNA following etoposide or gamma irradiation of primary salivary acinar cells.	Serine	110-116	thymoma viral proto-oncogene 1	Mus musculus	14-22	
18523362-7	2007	Either siRNA Raptor or siRNA Rictor suppressed TNF-alpha expression, but the latter suppressed the effects of GM3 on TNF-alpha expression and Akt phosphorylation at Ser(473), indicating the GM3 signal to be transduced via Rictor/mTOR and Akt (Ser(473)), leading to TNF-alpha stimulation.	Serine	165-168	thymoma viral proto-oncogene 1	Mus musculus	142-145	
16418171-5	2006	This Ser-318 phosphorylation improved insulin-stimulated Akt phosphorylation and glucose uptake in myotubes since transfection with an IRS-1/Glu-318 mutant simulating a permanent phospho-Ser-318 modification increased Akt phosphorylation and glucose uptake.	Serine	5-8	thymoma viral proto-oncogene 1	Mus musculus	57-60	
16778009-9	2006	In addition, INT-747 enhances both insulin-induced serine phosphorylation of Akt and glucose uptake by 3T3-L1 cells.	Serine	51-57	thymoma viral proto-oncogene 1	Mus musculus	77-80	
16823721-6	2006	Insulin-regulated serine phosphorylation of Akt and GSK3alpha and GSK3beta was unaltered in heart and skeletal muscle of knockout mice, suggesting unaltered insulin signaling.	Serine	18-24	thymoma viral proto-oncogene 1	Mus musculus	44-47	
16845229-8	2006	The involvement of PI 3-K /protein kinase B (PKB, Akt) pathway was confirmed by the results of the Western blot study, which showed that both drugs increased the level of active phospho-Ser-473 Akt, without changing the total Akt level, and decreased the level of active, nonphosphorylated glycogen synthase kinase-3 (GSK-3beta).	Serine	186-189	thymoma viral proto-oncogene 1	Mus musculus	45-48	
16845229-8	2006	The involvement of PI 3-K /protein kinase B (PKB, Akt) pathway was confirmed by the results of the Western blot study, which showed that both drugs increased the level of active phospho-Ser-473 Akt, without changing the total Akt level, and decreased the level of active, nonphosphorylated glycogen synthase kinase-3 (GSK-3beta).	Serine	186-189	thymoma viral proto-oncogene 1	Mus musculus	50-53	
16845229-8	2006	The involvement of PI 3-K /protein kinase B (PKB, Akt) pathway was confirmed by the results of the Western blot study, which showed that both drugs increased the level of active phospho-Ser-473 Akt, without changing the total Akt level, and decreased the level of active, nonphosphorylated glycogen synthase kinase-3 (GSK-3beta).	Serine	186-189	thymoma viral proto-oncogene 1	Mus musculus	194-197	
16845229-8	2006	The involvement of PI 3-K /protein kinase B (PKB, Akt) pathway was confirmed by the results of the Western blot study, which showed that both drugs increased the level of active phospho-Ser-473 Akt, without changing the total Akt level, and decreased the level of active, nonphosphorylated glycogen synthase kinase-3 (GSK-3beta).	Serine	186-189	thymoma viral proto-oncogene 1	Mus musculus	194-197	
16488889-1	2006	ARK5 is a tumor progression-associated factor that is directly phosphorylated by AKT at serine 600 in the regulatory domain, but phosphorylation at the conserved threonine residue on the active T loop has been found to be required for its full activation.	Serine	88-94	thymoma viral proto-oncogene 1	Mus musculus	81-84	
16157472-16	2006	These data provide the first evidence that PI 3 kinase-dependent Akt and PKCepsilon activation independently regulate MAPK activity and serine phosphorylation of STAT1alpha to increase expression of MCP-1.	Serine	136-142	thymoma viral proto-oncogene 1	Mus musculus	65-68	
16638822-7	2006	The preservation of insulin-induced tyrosine phosphorylation of IRbeta and IRS-1, of IRS-1 protein expression, and of insulin-induced serine phosphorylation of Akt observed in LPS-treated iNOS(-/-) mice strongly suggests that the insulin resistance induced by LPS is iNOS mediated, probably through S-nitrosation of proteins of early steps of insulin signaling.	Serine	134-140	thymoma viral proto-oncogene 1	Mus musculus	160-163	
16831409-12	2006	DMS also increased cytosolic Akt phosphorylation (Ser 473) and Akt translocation from a Triton-insoluble fraction to the cytosol.	Serine	50-53	thymoma viral proto-oncogene 1	Mus musculus	29-32	
16777975-5	2006	We examined signals that could activate muscle proteolysis and found low values of both phosphatidylinositol 3 kinase (PI3K) activity and phosphorylated Akt that were related to phosphorylation of serine 307 of insulin receptor substrate-1.	Serine	197-203	thymoma viral proto-oncogene 1	Mus musculus	153-156	
16157472-0	2006	PI 3 kinase-dependent Akt kinase and PKCepsilon independently regulate interferon-gamma-induced STAT1alpha serine phosphorylation to induce monocyte chemotactic protein-1 expression.	Serine	107-113	thymoma viral proto-oncogene 1	Mus musculus	22-25	
16157472-7	2006	Expression of dominant negative Akt kinase inhibited serine phosphorylation of STAT1alpha, without any effect on its tyrosine phosphorylation, and decreased IFN-gamma-induced expression of MCP-1.	Serine	53-59	thymoma viral proto-oncogene 1	Mus musculus	32-35	
16434614-6	2006	The phosphorylation of protein kinase B (Akt) (at serine 473), an essential mediator of IGF-I neuroprotective actions, increased after 17beta-estradiol and tended to increase with PPT but not with Delta5-diol treatments in MPTP mice.	Serine	50-56	thymoma viral proto-oncogene 1	Mus musculus	41-44	
16418171-5	2006	This Ser-318 phosphorylation improved insulin-stimulated Akt phosphorylation and glucose uptake in myotubes since transfection with an IRS-1/Glu-318 mutant simulating a permanent phospho-Ser-318 modification increased Akt phosphorylation and glucose uptake.	Serine	5-8	thymoma viral proto-oncogene 1	Mus musculus	218-221	
16418171-5	2006	This Ser-318 phosphorylation improved insulin-stimulated Akt phosphorylation and glucose uptake in myotubes since transfection with an IRS-1/Glu-318 mutant simulating a permanent phospho-Ser-318 modification increased Akt phosphorylation and glucose uptake.	Serine	187-190	thymoma viral proto-oncogene 1	Mus musculus	57-60	
16418171-5	2006	This Ser-318 phosphorylation improved insulin-stimulated Akt phosphorylation and glucose uptake in myotubes since transfection with an IRS-1/Glu-318 mutant simulating a permanent phospho-Ser-318 modification increased Akt phosphorylation and glucose uptake.	Serine	187-190	thymoma viral proto-oncogene 1	Mus musculus	218-221	
15925330-9	2005	However, serine phosphorylation of Akt in the arcuate nucleus of ob/ob mice increased significantly when compared to that in lean mice.	Serine	9-15	thymoma viral proto-oncogene 1	Mus musculus	35-38	
16338928-7	2006	Selective activation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced phospho-Ser-473-Akt, suggesting that activation of PKC inhibits Akt activity.	Serine	90-93	thymoma viral proto-oncogene 1	Mus musculus	98-101	
16338928-7	2006	Selective activation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced phospho-Ser-473-Akt, suggesting that activation of PKC inhibits Akt activity.	Serine	90-93	thymoma viral proto-oncogene 1	Mus musculus	146-149	
16338928-8	2006	TPA also attenuated IGF-1 and epidermal growth factor-induced phospho-Ser-473-Akt, reduced Akt kinase activity, and blocked IGF-1 protection from UVC-induced apoptosis.	Serine	70-73	thymoma viral proto-oncogene 1	Mus musculus	78-81	
16338928-11	2006	These studies indicated that PKCdelta and PKCepsilon were selectively potent at causing dephosphorylation of Akt and modifying cell survival, whereas PKCalpha enhanced phosphorylation of Akt on Ser-473.	Serine	194-197	thymoma viral proto-oncogene 1	Mus musculus	187-190	
15842198-12	2006	During resumption of meiosis, PKB phosphorylated on Ser(473) is associated with nuclear membrane and centrosome, whereas PKB phosphorylated on Thr(308) is localized on centrosome only.	Serine	52-55	thymoma viral proto-oncogene 1	Mus musculus	30-33	
16282323-7	2006	In vitro kinase assays showed that recombinant Akt could directly phosphorylate a GST-Bim(EL) fusion protein and identified the Akt phosphorylation site in the Bim(EL) domain as Ser(87).	Serine	178-181	thymoma viral proto-oncogene 1	Mus musculus	47-50	
16282323-7	2006	In vitro kinase assays showed that recombinant Akt could directly phosphorylate a GST-Bim(EL) fusion protein and identified the Akt phosphorylation site in the Bim(EL) domain as Ser(87).	Serine	178-181	thymoma viral proto-oncogene 1	Mus musculus	128-131	
16282323-10	2006	We propose that Ser(87) of Bim(EL) is an important regulatory site that is targeted by Akt to attenuate the pro-apoptotic function of Bim(EL), thereby promoting cell survival.	Serine	16-19	thymoma viral proto-oncogene 1	Mus musculus	87-90	
16208531-5	2006	Cell culture studies show that Akt-related phosphorylation of MDM2 at serine 166 allows MDM2 to gain nuclear entry and fulfil its p53 regulating function.	Serine	70-76	thymoma viral proto-oncogene 1	Mus musculus	31-34	
16208531-12	2006	These data confirm that MDM2 phosphorylation at serine 166 is mediated by Akt kinase.	Serine	48-54	thymoma viral proto-oncogene 1	Mus musculus	74-77	
16507763-10	2006	Furthermore, IC87114 treatment markedly attenuated OVA-induced serine phosphorylation of Akt, a downstream effector of PI3K signaling.	Serine	63-69	thymoma viral proto-oncogene 1	Mus musculus	89-92	
16338928-4	2006	During an examination of potential interactions among these two pathways, we found that the insulin-like growth factor (IGF-1) activates both the PKC and the Akt signaling pathways in cultured primary mouse keratinocytes as indicated by increased phospho-PKC and phospho-Ser-473-Akt.	Serine	271-274	thymoma viral proto-oncogene 1	Mus musculus	158-161	
16338928-6	2006	Furthermore, the PKC-specific inhibitor, GF109203X, increased IGF-1-induced phospho-Ser-473-Akt and Akt kinase activity and enhanced IGF-1 protection from UVC-induced apoptosis.	Serine	84-87	thymoma viral proto-oncogene 1	Mus musculus	92-95	
16141217-0	2005	Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588.	Serine	157-163	thymoma viral proto-oncogene 1	Mus musculus	83-99	
16141217-0	2005	Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588.	Serine	157-163	thymoma viral proto-oncogene 1	Mus musculus	101-104	
16141217-2	2005	In this study, we have identified APS as a novel substrate for protein kinase B/Akt using an antibody that exhibits insulin-dependent immunoreactivity with a phosphospecific antibody raised against the protein kinase B substrate consensus sequence RXRXX(pS/pT) and a phosphospecific antibody that recognizes serine 21/9 of glycogen synthase kinase-3alpha/beta.	Serine	308-314	thymoma viral proto-oncogene 1	Mus musculus	63-79	
16141217-2	2005	In this study, we have identified APS as a novel substrate for protein kinase B/Akt using an antibody that exhibits insulin-dependent immunoreactivity with a phosphospecific antibody raised against the protein kinase B substrate consensus sequence RXRXX(pS/pT) and a phosphospecific antibody that recognizes serine 21/9 of glycogen synthase kinase-3alpha/beta.	Serine	308-314	thymoma viral proto-oncogene 1	Mus musculus	80-83	
16141217-2	2005	In this study, we have identified APS as a novel substrate for protein kinase B/Akt using an antibody that exhibits insulin-dependent immunoreactivity with a phosphospecific antibody raised against the protein kinase B substrate consensus sequence RXRXX(pS/pT) and a phosphospecific antibody that recognizes serine 21/9 of glycogen synthase kinase-3alpha/beta.	Serine	308-314	thymoma viral proto-oncogene 1	Mus musculus	202-218	
16141217-4	2005	The insulin-stimulated serine phosphorylation of APS was inhibited by a PI3-kinase inhibitor, LY290004, a specific protein kinase B (PKB) inhibitor, deguelin, and knockdown of Akt.	Serine	23-29	thymoma viral proto-oncogene 1	Mus musculus	115-131	
16141217-4	2005	The insulin-stimulated serine phosphorylation of APS was inhibited by a PI3-kinase inhibitor, LY290004, a specific protein kinase B (PKB) inhibitor, deguelin, and knockdown of Akt.	Serine	23-29	thymoma viral proto-oncogene 1	Mus musculus	133-136	
16141217-4	2005	The insulin-stimulated serine phosphorylation of APS was inhibited by a PI3-kinase inhibitor, LY290004, a specific protein kinase B (PKB) inhibitor, deguelin, and knockdown of Akt.	Serine	23-29	thymoma viral proto-oncogene 1	Mus musculus	176-179	
16141217-5	2005	Serine 588 of APS is contained in a protein kinase B consensus sequence for phosphorylation conserved in APS across multiple species but not found in other members of this family, including SH2-B and Lnk.	Serine	0-6	thymoma viral proto-oncogene 1	Mus musculus	36-52	
16141217-7	2005	A glutathione S-transferase fusion protein containing amino acids 534-621 of APS was phosphorylated by purified PKB in vitro, and mutation of serine 588 abolished the PKB-mediated phosphorylation of APS in vitro.	Serine	142-148	thymoma viral proto-oncogene 1	Mus musculus	112-115	
16141217-7	2005	A glutathione S-transferase fusion protein containing amino acids 534-621 of APS was phosphorylated by purified PKB in vitro, and mutation of serine 588 abolished the PKB-mediated phosphorylation of APS in vitro.	Serine	142-148	thymoma viral proto-oncogene 1	Mus musculus	167-170	
15792956-7	2005	However, pretreatment of cells with the DNA-protein kinase (PK) inhibitor LY294002 strongly reversed silibinin-enhanced Akt-Ser(473) and p53-Ser(15) as well as ERK1/2 phosphorylation together with a dose-dependent decrease in cleaved caspase 3 and apoptosis (p &lt; 0.05).	Serine	124-127	thymoma viral proto-oncogene 1	Mus musculus	120-123	
15959754-8	2005	Also, an attenuated p85 regulatory subunit of phosphatidylinositol 3-kinase, Akt serine phosphorylation and the protein of glucose transporter subtype 4 were observed in insulin resistance.	Serine	81-87	thymoma viral proto-oncogene 1	Mus musculus	77-80	
15579463-12	2005	These results suggest that 1) Ser-10 phosphorylation is required for nuclear export of p27, 2) subsequent Akt-mediated phosphorylation at Thr-157 during G(1) phase corrals p27 in the cytosol, and 3) Thr-157 phosphorylation inhibits the association of p27 with importin alpha thus preventing its re-entry into the nucleus.	Serine	30-33	thymoma viral proto-oncogene 1	Mus musculus	106-109	
15684423-0	2005	Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40.	Serine	135-141	thymoma viral proto-oncogene 1	Mus musculus	36-39	
15688025-2	2005	Phosphorylation of HDM2 on serine 166 by AKT has been shown to enhance HDM2 activity and promote the degradation of p53.	Serine	27-33	thymoma viral proto-oncogene 1	Mus musculus	41-44	
15683846-7	2005	Western blot analysis of whole lung lysates shows that LY294002 markedly attenuated OVA-induced serine phosphorylation of Akt, a direct downstream substrate of PI3K.	Serine	96-102	thymoma viral proto-oncogene 1	Mus musculus	122-125	
15837948-4	2005	METHODS AND RESULTS: We show that insulin induces GATA2 phosphorylation on serine 401 in a PI-3K/Akt-dependent manner.	Serine	75-81	thymoma viral proto-oncogene 1	Mus musculus	97-100	
15278907-11	2004	Ser(473) phosphorylated Akt showed aberrant distribution and very low to undetectable levels of expression in LY294002-treated MI and MII oocytes, respectively.	Serine	0-3	thymoma viral proto-oncogene 1	Mus musculus	24-27	
15668399-5	2005	This effect of Skp2 requires Akt-specific phosphorylation of FOXO1 at Ser-256.	Serine	70-73	thymoma viral proto-oncogene 1	Mus musculus	29-32	
15591229-7	2005	This is mediated by serine 473 phosphorylation of Akt through PKA/Ca2+ and PI3K-dependent pathways.	Serine	20-26	thymoma viral proto-oncogene 1	Mus musculus	50-53	
15505117-8	2004	The clonidine-induced Ser-473 phosphorylation of Akt through PI3-K was significantly decreased in our model; however, that induced by ACh was not.	Serine	22-25	thymoma viral proto-oncogene 1	Mus musculus	49-52	
15517884-1	2004	The goal of the present study was to identify specific populations of cells that contain activated Akt-1, as determined by the presence ofphosphorylated Akt at serine 473 (p Akt), during development of skin tumors using a murine multi-stage carcinogenesis model.	Serine	160-166	thymoma viral proto-oncogene 1	Mus musculus	99-104	
15517884-1	2004	The goal of the present study was to identify specific populations of cells that contain activated Akt-1, as determined by the presence ofphosphorylated Akt at serine 473 (p Akt), during development of skin tumors using a murine multi-stage carcinogenesis model.	Serine	160-166	thymoma viral proto-oncogene 1	Mus musculus	99-102	
15517884-1	2004	The goal of the present study was to identify specific populations of cells that contain activated Akt-1, as determined by the presence ofphosphorylated Akt at serine 473 (p Akt), during development of skin tumors using a murine multi-stage carcinogenesis model.	Serine	160-166	thymoma viral proto-oncogene 1	Mus musculus	153-156	
15130773-7	2004	Furthermore, DEP promoted phosphorylation of Akt, a substrate of phosphatidylinositol 3-kinase (PI3K), on Ser-473 and Thr-308 in a PI3K-dependent manner, and enhanced phosphorylation of down-stream p70/p85 S6 kinases (p70/p85S6K) as well as glycogen synthase kinase-3beta (GSK-3beta).	Serine	106-109	thymoma viral proto-oncogene 1	Mus musculus	45-48	
15123689-6	2004	In response to IL-7, the PI3K/Akt pathway induced phosphorylation at Ser-136 and -155, but Ser-112 was partly independent of the PI3K/Akt pathway, indicating an as yet unknown pathway in this response.	Serine	69-72	thymoma viral proto-oncogene 1	Mus musculus	30-33	
14656892-11	2004	Serine phosphorylation of Akt, a marker of PI3-kinase activity, was detected in both wild-type and truncated proximal domain receptors, but not in the ADA and W650R mutants.	Serine	0-6	thymoma viral proto-oncogene 1	Mus musculus	26-29	
14998989-8	2004	The effects of LG268 on the IRS-1/Akt pathway were associated with a decrease in the level of IRS-1 Ser(307) phosphorylation.	Serine	100-103	thymoma viral proto-oncogene 1	Mus musculus	34-37	
12875741-7	2003	In both young (P&lt;0.01) and aged (P&lt;0.05) mice, des IGF-I significantly increased the phosphorylation of Akt-1 at Ser 473.	Serine	119-122	thymoma viral proto-oncogene 1	Mus musculus	110-115	
15065872-3	2004	In heat-shocked cells, PKBalpha was activated to a certain level without phosphorylation on Thr-308 in the activation loop and on Thr-450 and Ser-473 in the carboxyl-terminal end region, which is critical for growth-factor-induced activation of PKBalpha.	Serine	142-145	thymoma viral proto-oncogene 1	Mus musculus	23-31	
14522959-4	2003	Elevated levels of activated Ser(P)473-Akt are detected in extracts of Hdh(Q111/Q111) striatum and cultured mutant STHdh(Q111/Q111) striatal cells, compared with their wild type counterparts.	Serine	29-32	thymoma viral proto-oncogene 1	Mus musculus	39-42	
14522959-7	2003	Akt activation is phosphatidylinositol 3-kinase dependent, as demonstrated by increased levels of Ser(P)241-PDK1 kinase and decreased Ser(P)380-PTEN phosphatase.	Serine	98-101	thymoma viral proto-oncogene 1	Mus musculus	0-3	
14522959-7	2003	Akt activation is phosphatidylinositol 3-kinase dependent, as demonstrated by increased levels of Ser(P)241-PDK1 kinase and decreased Ser(P)380-PTEN phosphatase.	Serine	134-137	thymoma viral proto-oncogene 1	Mus musculus	0-3	
14522959-10	2003	Akt activation in mutant striatal cells is Ca(2+)-dependent, because treatment with EGTA reduces levels of Ser(P)473-Akt.	Serine	107-110	thymoma viral proto-oncogene 1	Mus musculus	0-3	
14522959-10	2003	Akt activation in mutant striatal cells is Ca(2+)-dependent, because treatment with EGTA reduces levels of Ser(P)473-Akt.	Serine	107-110	thymoma viral proto-oncogene 1	Mus musculus	117-120	
12738898-1	2003	BACKGROUND AND PURPOSE: The serine-threonine kinase Akt is activated by phosphorylation at serine-473.	Serine	28-34	thymoma viral proto-oncogene 1	Mus musculus	52-55	
12672057-4	2003	IL-7 also blocked dexamethasone-triggered dephosphorylation of the serine-threonine kinase Akt/PKB and its target, the Ser(136) residue in Bad.	Serine	119-122	thymoma viral proto-oncogene 1	Mus musculus	91-94	
12637511-4	2003	Stable expression of a beta(1) integrin mutated at this amino acid in GD25 beta(1)-null cells resulted in reduction of Akt phosphorylation at both Ser(473) and Thr(308) activation sites.	Serine	147-150	thymoma viral proto-oncogene 1	Mus musculus	119-122	
12672057-4	2003	IL-7 also blocked dexamethasone-triggered dephosphorylation of the serine-threonine kinase Akt/PKB and its target, the Ser(136) residue in Bad.	Serine	119-122	thymoma viral proto-oncogene 1	Mus musculus	95-98	
12351401-9	2002	Cross-linking CD150 on CD4 T cells induces rapid serine phosphorylation of Akt/PKB.	Serine	49-55	thymoma viral proto-oncogene 1	Mus musculus	75-82	
12529330-0	2003	Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1.	Serine	50-56	thymoma viral proto-oncogene 1	Mus musculus	75-79	
12529330-4	2003	Arsenite induces phosphorylation of Akt1 at serine 473 and increases Akt1 activity.	Serine	44-50	thymoma viral proto-oncogene 1	Mus musculus	36-40	
12529330-5	2003	A dominant-negative mutant of Akt1 inhibits the arsenite-induced phosphorylation of histone H3 at serine 10.	Serine	98-104	thymoma viral proto-oncogene 1	Mus musculus	30-34	
12529330-6	2003	Additionally, active Akt1 kinase strongly phosphorylates histone H3 at serine 10 in vitro.	Serine	71-77	thymoma viral proto-oncogene 1	Mus musculus	21-25	
12529330-10	2003	Taken together, these results suggested that arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2 and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1.	Serine	95-101	thymoma viral proto-oncogene 1	Mus musculus	120-124	
12489109-5	2002	The data obtained with Akt-transformed keratinocytes clearly suggested the involvement of Akt in serine 9 phosphorylation of GSK-3beta.	Serine	97-103	thymoma viral proto-oncogene 1	Mus musculus	23-26	
12489109-5	2002	The data obtained with Akt-transformed keratinocytes clearly suggested the involvement of Akt in serine 9 phosphorylation of GSK-3beta.	Serine	97-103	thymoma viral proto-oncogene 1	Mus musculus	90-93	
12190109-4	2002	In both skeletal and cardiac muscle, des IGF-I increased the phosphorylation of Akt-1 at Ser 473 (p &lt; 0.01) with no change in the phosphorylation of p44 and p42 MAP kinases at Thr202/Tyr204.	Serine	89-92	thymoma viral proto-oncogene 1	Mus musculus	80-85	
12153489-7	2002	Concurrently, ST-treatment significantly decreased the phosphorylation status of Akt at Ser-473 and Thr-308 as well as Akt activity, and this reduction was partially prevented by DHA enrichment.	Serine	88-91	thymoma viral proto-oncogene 1	Mus musculus	81-84	
12217896-7	2002	Glucose activation of the protein kinase Akt was demonstrated in both insulinoma cells and cultured mouse islets by means of an antibody specific for Ser(473) phospho-Akt and by an in vitro Akt kinase assay.	Serine	150-153	thymoma viral proto-oncogene 1	Mus musculus	41-44	
11507090-4	2001	This phosphorylation was confirmed by the observation that overexpression of Akt mutant, Akt-T308/S473A, attenuated phosphorylation of Akt at Ser-473 and Thr-308.	Serine	142-145	thymoma viral proto-oncogene 1	Mus musculus	77-80	
11950275-2	2002	The present study examined phosphorylation of Akt at serine-473 and DNA fragmentation after traumatic brain injury (TBI) in mice.	Serine	53-59	thymoma viral proto-oncogene 1	Mus musculus	46-49	
11571285-7	2001	InlB also activated the PI 3-kinase downstream effector, Akt, as assessed by increased phosphorylation of Akt on serine 473.	Serine	113-119	thymoma viral proto-oncogene 1	Mus musculus	57-60	
11571285-7	2001	InlB also activated the PI 3-kinase downstream effector, Akt, as assessed by increased phosphorylation of Akt on serine 473.	Serine	113-119	thymoma viral proto-oncogene 1	Mus musculus	106-109	
11740206-1	2001	The serine-threonine kinase, Akt, prevents apoptosis by phosphorylation at serine-473 in several cell systems.	Serine	4-10	thymoma viral proto-oncogene 1	Mus musculus	29-32	
11740206-3	2001	The present study examined phosphorylation of Akt at serine-473 and DNA fragmentation after transient focal cerebral ischemia in mice subjected to 60 minutes of focal cerebral ischemia by intraluminal blockade of the middle cerebral artery.	Serine	53-59	thymoma viral proto-oncogene 1	Mus musculus	46-49	
11507090-0	2001	UV Induces phosphorylation of protein kinase B (Akt) at Ser-473 and Thr-308 in mouse epidermal Cl 41 cells through hydrogen peroxide.	Serine	56-59	thymoma viral proto-oncogene 1	Mus musculus	48-51	
11507090-3	2001	Exposure of mouse epidermal JB6 Cl 41 cells to UV radiation led to specific phosphorylation of Akt at Ser-473 and Thr-308 in a time-dependent manner.	Serine	102-105	thymoma viral proto-oncogene 1	Mus musculus	95-98	
11507090-4	2001	This phosphorylation was confirmed by the observation that overexpression of Akt mutant, Akt-T308/S473A, attenuated phosphorylation of Akt at Ser-473 and Thr-308.	Serine	142-145	thymoma viral proto-oncogene 1	Mus musculus	89-92	
11507090-4	2001	This phosphorylation was confirmed by the observation that overexpression of Akt mutant, Akt-T308/S473A, attenuated phosphorylation of Akt at Ser-473 and Thr-308.	Serine	142-145	thymoma viral proto-oncogene 1	Mus musculus	89-92	
11507090-9	2001	The scavenging of UV-generated H(2)O(2) by N-acety-l-cyteine (NAC, a general antioxidant) or catalase (a specific H(2)O(2) inhibitor) inhibited Akt phosphorylation at Ser-473 and Thr-308, whereas the pretreatment of cells with sodium formate (an .OH radical scavenger) or superoxide dismutase (an O(-.2) radical scavenger) did not show any inhibitory effects.	Serine	167-170	thymoma viral proto-oncogene 1	Mus musculus	144-147	
11507090-10	2001	Furthermore, treatment of cells with H(2)O(2) increased UV-induced phosphorylation of Akt at Ser-473 and Thr-308.	Serine	93-96	thymoma viral proto-oncogene 1	Mus musculus	86-89	
11507090-11	2001	These results demonstrate that UV radiation generates a whole spectrum of ROS including O(-.2), .OH, and H(2)O(2) and induces phosphorylation of Akt at Ser-473.	Serine	152-155	thymoma viral proto-oncogene 1	Mus musculus	145-148	
11507090-12	2001	Among the various ROS, H(2)O(2) seems most potent in mediating UV-induced phosphorylation of Akt at Ser-473 and Thr-308.	Serine	100-103	thymoma viral proto-oncogene 1	Mus musculus	93-96	
11402048-0	2001	Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179).	Serine	100-103	thymoma viral proto-oncogene 1	Mus musculus	93-96	
11563975-7	2001	In WEHI cells overexpressing a form of PKB, IGF-1 increased phosphorylation of Ser(473) on PKB, but not its kinase activity, whereas TNF-alpha failed to induce Ser(473) phosphorylation or kinase activation of either overexpressed T308A or wild-type PKB (where T308A is the mutant bearing the substitution Thr(308)--&gt;A).	Serine	79-82	thymoma viral proto-oncogene 1	Mus musculus	39-42	
11563975-7	2001	In WEHI cells overexpressing a form of PKB, IGF-1 increased phosphorylation of Ser(473) on PKB, but not its kinase activity, whereas TNF-alpha failed to induce Ser(473) phosphorylation or kinase activation of either overexpressed T308A or wild-type PKB (where T308A is the mutant bearing the substitution Thr(308)--&gt;A).	Serine	79-82	thymoma viral proto-oncogene 1	Mus musculus	91-94	
11563975-7	2001	In WEHI cells overexpressing a form of PKB, IGF-1 increased phosphorylation of Ser(473) on PKB, but not its kinase activity, whereas TNF-alpha failed to induce Ser(473) phosphorylation or kinase activation of either overexpressed T308A or wild-type PKB (where T308A is the mutant bearing the substitution Thr(308)--&gt;A).	Serine	79-82	thymoma viral proto-oncogene 1	Mus musculus	91-94	
11563975-7	2001	In WEHI cells overexpressing a form of PKB, IGF-1 increased phosphorylation of Ser(473) on PKB, but not its kinase activity, whereas TNF-alpha failed to induce Ser(473) phosphorylation or kinase activation of either overexpressed T308A or wild-type PKB (where T308A is the mutant bearing the substitution Thr(308)--&gt;A).	Serine	160-163	thymoma viral proto-oncogene 1	Mus musculus	39-42	
11563975-9	2001	We conclude that, at physiological concentrations, TNF-alpha activates endogenous PKB by stimulating PDK2 (increase in Ser(473) phosphorylation) in a PI3-kinase-dependent (wortmannin-sensitive) manner, without causing detectable stimulation of PDK1 (no increase in Thr(308) phosphorylation) or ARNO translocation.	Serine	119-122	thymoma viral proto-oncogene 1	Mus musculus	82-85	
11133986-10	2001	Substitution analyses within this region indicate that phosphorylation of Ser(41) is necessary to respond to AKT.	Serine	74-77	thymoma viral proto-oncogene 1	Mus musculus	109-112	
10747954-7	2000	Furthermore, insulin-stimulated insulin receptor and Akt Ser(473) phosphorylation and phosphatidylinositol 3-kinase activity were 1.6-2.5-fold greater in skeletal muscle from C/EBPbeta(-/-) mice compared with WT mice.	Serine	57-60	thymoma viral proto-oncogene 1	Mus musculus	53-56	
11113183-10	2001	However, insulin-stimulated serine phosphorylation of Akt was significantly higher in the KO animals.	Serine	28-34	thymoma viral proto-oncogene 1	Mus musculus	54-57	
11018758-5	2000	Insulin increased Akt-Ser(473) phosphorylation by two- to fivefold in muscle and adipose tissue from all mice.	Serine	22-25	thymoma viral proto-oncogene 1	Mus musculus	18-21	
11018758-6	2000	However, in db/db mice, maximal Akt-Ser(473) phosphorylation was decreased by 32% (P&lt;0.05) and 69% (P&lt;0.05) in muscle and adipose tissue respectively.	Serine	36-39	thymoma viral proto-oncogene 1	Mus musculus	32-35	
11006271-1	2000	Phosphorylation of Thr(308) in the activation loop and Ser(473) at the carboxyl terminus is essential for protein kinase B (PKB/Akt) activation.	Serine	55-58	thymoma viral proto-oncogene 1	Mus musculus	124-131	
10969078-2	2000	In NMuMG mammary epithelial cells, exogenous TGFbeta1 induced phosphorylation of Akt at Ser-473 and Akt in vitro kinase activity against GSK-3beta within 30 min.	Serine	88-91	thymoma viral proto-oncogene 1	Mus musculus	81-84	
10969078-7	2000	Dominant-negative RhoA inhibited TGFbeta-induced phosphorylation of Akt at Ser-473, whereas constitutively active RhoA increased the basal phosphorylation of Akt, suggesting that RhoA in involved in TGFbeta-induced EMT.	Serine	75-78	thymoma viral proto-oncogene 1	Mus musculus	68-71	
10714768-9	2000	We now show in detached cells a cooperative effect of HGF and FN in the activation of PI 3-kinase and on the phosphorylation of PKB/Akt at serine 473.	Serine	139-145	thymoma viral proto-oncogene 1	Mus musculus	128-131	
10714768-9	2000	We now show in detached cells a cooperative effect of HGF and FN in the activation of PI 3-kinase and on the phosphorylation of PKB/Akt at serine 473.	Serine	139-145	thymoma viral proto-oncogene 1	Mus musculus	132-135	
34848742-3	2021	We hypothesized that the AhR enhances the activation of the AKT serine/threonine kinase (Akt) pathway to promote cell survival.	Serine	64-70	thymoma viral proto-oncogene 1	Mus musculus	89-92	
10438924-4	1999	Using an Ab that specifically recognizes the activated form of Akt that is phosphorylated on serine 473, we show that BCR engagement activates Akt in a PI 3-kinase-dependent manner.	Serine	93-99	thymoma viral proto-oncogene 1	Mus musculus	63-66	
10438924-4	1999	Using an Ab that specifically recognizes the activated form of Akt that is phosphorylated on serine 473, we show that BCR engagement activates Akt in a PI 3-kinase-dependent manner.	Serine	93-99	thymoma viral proto-oncogene 1	Mus musculus	143-146	
10438924-7	1999	In the DT40 chicken B cell line, phosphorylation of Akt on serine 473 was completely dependent on the Lyn tyrosine kinase, while the Syk tyrosine kinase was required for sustained phosphorylation of Akt.	Serine	59-65	thymoma viral proto-oncogene 1	Mus musculus	52-55	
10438924-8	1999	Complementary experiments in BCR-expressing AtT20 endocrine cells confirmed that Src kinases are sufficient for BCR-induced Akt phosphorylation, but that Syk is required for sustained phosphorylation of Akt on both serine 473 and threonine 308.	Serine	215-221	thymoma viral proto-oncogene 1	Mus musculus	203-206	
9927197-7	1999	Rac-induced Akt activation was mediated by phosphorylation of threonine-308 and serine-473.	Serine	80-86	thymoma viral proto-oncogene 1	Mus musculus	0-3	
9927197-7	1999	Rac-induced Akt activation was mediated by phosphorylation of threonine-308 and serine-473.	Serine	80-86	thymoma viral proto-oncogene 1	Mus musculus	12-15	
34331233-7	2021	Consequently, glucose stimulation failed to activate the downstream molecule phosphatidylinositol-3 kinase (PI3K) in 160Q cells, leading to reduced phosphorylation levels of serine-threonine protein kinase AKT and forkhead box protein O1 (FoxO1).	Serine	174-180	thymoma viral proto-oncogene 1	Mus musculus	206-209	
10597260-7	1999	Both basal and interleukin 3-stimulated phosphorylation of Akt on serine 473 was enhanced in the PKC-alpha and Akt contransfectants.	Serine	66-72	thymoma viral proto-oncogene 1	Mus musculus	59-62	
10597260-7	1999	Both basal and interleukin 3-stimulated phosphorylation of Akt on serine 473 was enhanced in the PKC-alpha and Akt contransfectants.	Serine	66-72	thymoma viral proto-oncogene 1	Mus musculus	111-114	
10454575-4	1999	Serine-273 of mouse PDE3B is located within a motif (RXRXXS) that is preferentially phosphorylated by Akt.	Serine	0-6	thymoma viral proto-oncogene 1	Mus musculus	102-105	
10454575-8	1999	These results suggest that PDE3B is a physiological substrate of Akt and that Akt-mediated phosphorylation of PDE3B on serine-273 is important for insulin-induced activation of PDE3B.	Serine	119-125	thymoma viral proto-oncogene 1	Mus musculus	65-68	
10454575-8	1999	These results suggest that PDE3B is a physiological substrate of Akt and that Akt-mediated phosphorylation of PDE3B on serine-273 is important for insulin-induced activation of PDE3B.	Serine	119-125	thymoma viral proto-oncogene 1	Mus musculus	78-81	
8510938-3	1993	v-akt encodes a 105 kilodalton (kd) Gag-Akt fusion protein which is phosphorylated on serine and threonine residues.	Serine	86-92	thymoma viral proto-oncogene 1	Mus musculus	2-5	
8510938-3	1993	v-akt encodes a 105 kilodalton (kd) Gag-Akt fusion protein which is phosphorylated on serine and threonine residues.	Serine	86-92	thymoma viral proto-oncogene 1	Mus musculus	40-43	
34917687-8	2021	The results showed that glargine was able to upregulate the expression of PI3K and activate serine phosphorylation of AKT through the upregulation of Cav-1 expression in paraepididymal adipose tissue of the insulin group.	Serine	92-98	thymoma viral proto-oncogene 1	Mus musculus	118-121	
34695518-8	2021	These results suggest PTEN and mTORC2 are associated with cellular senescence in VSMCs and that the mTORC2-Akt (Ser 473) signaling pathway be considered a new target for preventing senescence-related diseases.	Serine	112-115	thymoma viral proto-oncogene 1	Mus musculus	107-110	
34465724-9	2021	In addition, loss of function of NOTCH1 suppresses HER3 expression through increased phosphorylation of serine 473 of AKT in SCCHN cells, and promotes the aggressiveness of the tumor cells.	Serine	104-110	thymoma viral proto-oncogene 1	Mus musculus	118-121	
34751006-2	2022	Insulin and insulin-like growth factor-1 (IGF-1) are two potent anabolic hormones that activate a host of signalling intermediates including the serine/threonine kinase AKT to influence skeletal muscle physiology.	Serine	145-151	thymoma viral proto-oncogene 1	Mus musculus	169-172	
34769428-6	2021	Moreover, it suppressed the expression of Th2 type cytokines and chemokines in the AD mouse model and TNF-alpha/IFN-gamma-induced HaCaT keratinocytes by blocking the activation of serine-threonine kinase Akt, nuclear factor-kappaB, and the signal transducer and activator of transcription 1.	Serine	180-186	thymoma viral proto-oncogene 1	Mus musculus	204-207	
34666331-2	2021	OBJECTIVES: Previous studies showed that CALR mutations not only activated serine/threonine protein kinase (AKT) in primary mouse bone marrow cells but also mitogen-activated protein kinases (MAPKs) in MARIMO cells harboring a heterozygous 61-bp deletion in CALR exon 9, which were responsible for mutant CALR cell survival, respectively.	Serine	75-81	thymoma viral proto-oncogene 1	Mus musculus	108-111	
34068807-7	2021	Targeting BDNF receptor tropomyosin receptor kinase B (TRK-B) with siRNA knockdown substantially downregulated the activated (phosphorylated) form of serine/threonine-specific protein kinase (AKT) and extracellular signal-regulated kinase (ERK), classical survival and proliferation mediators.	Serine	150-156	thymoma viral proto-oncogene 1	Mus musculus	192-195	
34082428-6	2021	Moreover, pioglitazone significantly increased beta-arrestin2 signaling in all the examined tissues as estimated from significant increases in phosphatidylinositol 4,5 bisphosphate and phosphorylation of Akt at serine 473 and significant decrease in diacylglycerol level.	Serine	211-217	thymoma viral proto-oncogene 1	Mus musculus	204-207	
35617801-11	2022	An underlying improvement in synaptic plasticity was observed with MP treatment in 5XFAD mice along with an increased expression of phospho-Akt at serine 473 indicating a role of PI3K/Akt signaling in correcting these synaptic deficits.	Serine	147-153	thymoma viral proto-oncogene 1	Mus musculus	140-143	
35576690-6	2022	Furthermore, we found that signal transducer and activator of transcription 3 (STAT3) and serine/threonine kinase Akt (AKT) were upregulated in AKAP12Deltahep mice of chronic liver injury.	Serine	90-96	thymoma viral proto-oncogene 1	Mus musculus	114-117	
35576690-6	2022	Furthermore, we found that signal transducer and activator of transcription 3 (STAT3) and serine/threonine kinase Akt (AKT) were upregulated in AKAP12Deltahep mice of chronic liver injury.	Serine	90-96	thymoma viral proto-oncogene 1	Mus musculus	119-122	
35344847-5	2022	According to our findings, recombinant CXCL10 protein (rmCXCL10) could increase the phosphorylation of serine-threonine kinase AKT reduced by morphine in spinal cord.	Serine	103-109	thymoma viral proto-oncogene 1	Mus musculus	127-130	
35565964-4	2022	The results also showed that bergapten promotes the phosphorylation of Akt at Ser 473 and glycogen synthase kinase-3beta at Ser 9.	Serine	78-81	thymoma viral proto-oncogene 1	Mus musculus	71-74	
35532280-1	2022	The serine/threonine protein kinase Akt integrates diverse upstream inputs to regulate cell survival, growth, metabolism, migration, and differentiation.	Serine	4-10	thymoma viral proto-oncogene 1	Mus musculus	36-39	
34988938-11	2022	RESULTS: Treatment with BKM120 decreased AtT-20/D16v-F2 cell viability, induced a G0/G1 cell cycle arrest, reduced the phosphorylation of Akt at Serine 473, and increased p27 expression.	Serine	145-151	thymoma viral proto-oncogene 1	Mus musculus	138-141	
35565964-4	2022	The results also showed that bergapten promotes the phosphorylation of Akt at Ser 473 and glycogen synthase kinase-3beta at Ser 9.	Serine	124-127	thymoma viral proto-oncogene 1	Mus musculus	71-74	
35202857-8	2022	These effects were mediated by the cluster of differentiation (CD)-44 and phosphorylation of serine-threonine kinase (Akt).	Serine	93-99	thymoma viral proto-oncogene 1	Mus musculus	118-121