PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27064126-5 2016 l-Serine inhibited homocysteine-induced ER stress as verified by decreased glucose-regulated protein 78kDa (GRP78) and C/EBP homologous protein (CHOP) expression as well as X-box binding protein 1 (xbp1) mRNA splicing. Serine 0-8 DNA damage inducible transcript 3 Homo sapiens 119-143 27650555-6 2016 Mechanistically, AMPKalpha1 was found to coimmunoprecipitate with CHOP and phosphorylate CHOP at serine 30. Serine 97-103 DNA damage inducible transcript 3 Homo sapiens 89-93 27650555-7 2016 Furthermore, serine 30 phosphorylation of CHOP triggered its ubiquitination and proteasomal degradation. Serine 13-19 DNA damage inducible transcript 3 Homo sapiens 42-46 27650555-11 2016 CONCLUSIONS: Our results indicate that AMPKalpha1 mediates CHOP ubiquitination and proteasomal degradation in macrophages by promoting the phosphorylation of CHOP at serine 30. Serine 166-172 DNA damage inducible transcript 3 Homo sapiens 59-63 27481183-3 2016 At the protein expression level, compared to the lean, the phosphorylation of AMPK, and p-Akt at serine 473 were significantly reduced from the overweight (OW) and/or obese (OB); while the protein expression of p-JNK, cleaved caspase 3, CHOP and p-eIF2alpha were elevated from the OW and/or OB. Serine 97-103 DNA damage inducible transcript 3 Homo sapiens 237-241 27064126-5 2016 l-Serine inhibited homocysteine-induced ER stress as verified by decreased glucose-regulated protein 78kDa (GRP78) and C/EBP homologous protein (CHOP) expression as well as X-box binding protein 1 (xbp1) mRNA splicing. Serine 0-8 DNA damage inducible transcript 3 Homo sapiens 145-149 21115923-6 2010 RT-PCR analysis confirmed the presence of EWS-CHOP chimeric transcript type 1, in which exon 7 of EWS was in-frame fused to exon 2 of CHOP with a serine (AGT) to methionine (ATG) transition at the junction. Serine 146-152 DNA damage inducible transcript 3 Homo sapiens 46-50 24990631-7 2014 SPOP recognizes a Ser/Thr-rich degron in the transactivation domain of DDIT3 and triggers DDIT3 degradation via the ubiquitin-proteasome pathway. Serine 18-21 DNA damage inducible transcript 3 Homo sapiens 71-76 24990631-7 2014 SPOP recognizes a Ser/Thr-rich degron in the transactivation domain of DDIT3 and triggers DDIT3 degradation via the ubiquitin-proteasome pathway. Serine 18-21 DNA damage inducible transcript 3 Homo sapiens 90-95 21115923-6 2010 RT-PCR analysis confirmed the presence of EWS-CHOP chimeric transcript type 1, in which exon 7 of EWS was in-frame fused to exon 2 of CHOP with a serine (AGT) to methionine (ATG) transition at the junction. Serine 146-152 DNA damage inducible transcript 3 Homo sapiens 134-138 12876286-4 2003 Phosphorylation of CHOP at serine 79 and serine 81 by p38-MAP kinase enhances its transcriptional activity. Serine 27-33 DNA damage inducible transcript 3 Homo sapiens 19-23 11381086-1 2001 Phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) on serine 51 integrates general translation repression with activation of stress-inducible genes such as ATF4, CHOP, and BiP in the unfolded protein response. Serine 98-104 DNA damage inducible transcript 3 Homo sapiens 206-210