PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10947965-1 2000 We have determined that the mutation of the cysteine-230 residue to either glycine or serine in TRAIL (tumour necrosis factor-alpha-related apoptosis-inducing ligand) results in the formation of a structurally incompetent dimer and a consequent loss of apoptotic activity. Serine 86-92 TNF superfamily member 10 Homo sapiens 96-101 12649200-3 2003 Apoptosis assays and Western blot analyses revealed that apoptosis resistance to TRAIL correlates well with the level of Akt phosphorylation at Ser 473 rather than protein expression levels of TRAIL receptors, DR4 and DR5. Serine 144-147 TNF superfamily member 10 Homo sapiens 81-86 10947965-1 2000 We have determined that the mutation of the cysteine-230 residue to either glycine or serine in TRAIL (tumour necrosis factor-alpha-related apoptosis-inducing ligand) results in the formation of a structurally incompetent dimer and a consequent loss of apoptotic activity. Serine 86-92 TNF superfamily member 10 Homo sapiens 103-165 24308965-7 2014 By overexpression of HSP27(15A) or HSP27(78/82A) phosphorylation mutant, we further showed that phosphorylation of HSP27 at serine 78/82 residues was essential to TRAIL-triggered Src-Akt/ERK signaling transduction. Serine 124-130 TNF superfamily member 10 Homo sapiens 163-168 26572549-10 2015 Importantly, TRAIL-inducible endothelial nitric oxide synthase phosphorylation at Ser-1177 and intracellular human microvascular endothelial cell-1 cell nitric oxide levels were NOX4 dependent. Serine 82-85 TNF superfamily member 10 Homo sapiens 13-18 26165401-5 2015 Downregulation of CK2 combined with a sub-dose of TRAIL suppressed p65 phosphorylation at serine 536. Serine 90-96 TNF superfamily member 10 Homo sapiens 50-55 21683075-8 2011 Mimicking constitutive phosphorylation of Bcl-xL by site-directed mutagenesis at serine 62 restored sensitivity of cells to TRAIL. Serine 81-87 TNF superfamily member 10 Homo sapiens 124-129 23587601-5 2013 Treatment of LX-2 cells with TRAIL decreased the active trimer formation of HSF1, increased the dephosphorylation of HSF1 (Ser(230)), and enhanced the translocation of HSF1 into cytosol. Serine 123-126 TNF superfamily member 10 Homo sapiens 29-34 15368357-3 2004 These preliminary results let us to speculate on the possible involvement of PI-3-kinase in TRAIL resistance disclosed by surviving cells (20%), may be phosphorylating Akt-1 and, in parallel, IkappaB alpha on both serine and tyrosine residues. Serine 214-220 TNF superfamily member 10 Homo sapiens 92-97 15252032-6 2004 The late phase of TRAIL-induced NF-kappaB activation involves caspase mediated cleavage of IkappaBalpha between Asp(31) and Ser(32) residues to generate an N-terminal truncated fragment that is degraded by the proteasome via the N-end rule pathway. Serine 124-127 TNF superfamily member 10 Homo sapiens 18-23