PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10947965-1	2000	We have determined that the mutation of the cysteine-230 residue to either glycine or serine in TRAIL (tumour necrosis factor-alpha-related apoptosis-inducing ligand) results in the formation of a structurally incompetent dimer and a consequent loss of apoptotic activity.	Serine	86-92	TNF superfamily member 10	Homo sapiens	96-101	
12649200-3	2003	Apoptosis assays and Western blot analyses revealed that apoptosis resistance to TRAIL correlates well with the level of Akt phosphorylation at Ser 473 rather than protein expression levels of TRAIL receptors, DR4 and DR5.	Serine	144-147	TNF superfamily member 10	Homo sapiens	81-86	
10947965-1	2000	We have determined that the mutation of the cysteine-230 residue to either glycine or serine in TRAIL (tumour necrosis factor-alpha-related apoptosis-inducing ligand) results in the formation of a structurally incompetent dimer and a consequent loss of apoptotic activity.	Serine	86-92	TNF superfamily member 10	Homo sapiens	103-165	
24308965-7	2014	By overexpression of HSP27(15A) or HSP27(78/82A) phosphorylation mutant, we further showed that phosphorylation of HSP27 at serine 78/82 residues was essential to TRAIL-triggered Src-Akt/ERK signaling transduction.	Serine	124-130	TNF superfamily member 10	Homo sapiens	163-168	
26572549-10	2015	Importantly, TRAIL-inducible endothelial nitric oxide synthase phosphorylation at Ser-1177 and intracellular human microvascular endothelial cell-1 cell nitric oxide levels were NOX4 dependent.	Serine	82-85	TNF superfamily member 10	Homo sapiens	13-18	
26165401-5	2015	Downregulation of CK2 combined with a sub-dose of TRAIL suppressed p65 phosphorylation at serine 536.	Serine	90-96	TNF superfamily member 10	Homo sapiens	50-55	
21683075-8	2011	Mimicking constitutive phosphorylation of Bcl-xL by site-directed mutagenesis at serine 62 restored sensitivity of cells to TRAIL.	Serine	81-87	TNF superfamily member 10	Homo sapiens	124-129	
23587601-5	2013	Treatment of LX-2 cells with TRAIL decreased the active trimer formation of HSF1, increased the dephosphorylation of HSF1 (Ser(230)), and enhanced the translocation of HSF1 into cytosol.	Serine	123-126	TNF superfamily member 10	Homo sapiens	29-34	
15368357-3	2004	These preliminary results let us to speculate on the possible involvement of PI-3-kinase in TRAIL resistance disclosed by surviving cells (20%), may be phosphorylating Akt-1 and, in parallel, IkappaB alpha on both serine and tyrosine residues.	Serine	214-220	TNF superfamily member 10	Homo sapiens	92-97	
15252032-6	2004	The late phase of TRAIL-induced NF-kappaB activation involves caspase mediated cleavage of IkappaBalpha between Asp(31) and Ser(32) residues to generate an N-terminal truncated fragment that is degraded by the proteasome via the N-end rule pathway.	Serine	124-127	TNF superfamily member 10	Homo sapiens	18-23