PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18003885-3 2008 Phosphorylation of RUNX1 by cdks on serine 303 was shown to mediate destabilization of RUNX1 in G2/M. Serine 36-42 runt related transcription factor 1 Mus musculus 19-24 18003885-3 2008 Phosphorylation of RUNX1 by cdks on serine 303 was shown to mediate destabilization of RUNX1 in G2/M. Serine 36-42 runt related transcription factor 1 Mus musculus 87-92 22531928-2 2012 It has been shown that RUNX1 is phosphorylated at specific serine and threonine residues by several kinase families. Serine 59-65 runt related transcription factor 1 Mus musculus 23-28 22531928-4 2012 Here, we evaluated hematopoietic activities of RUNX1 mutants with serine (S)/threonine (T) to alanine (A), aspartic acid (D), or glutamic acid (E) mutations at phosphorylation sites using primary culture systems. Serine 66-72 runt related transcription factor 1 Mus musculus 47-52 21059642-7 2011 Finally, RUNX1 or RUNX1(tripleD), in which Ser-48, Ser-303, and Ser-424 are mutated to aspartic acid, stimulated proliferation of transduced, lineage-negative murine marrow progenitors more potently than did RUNX1(tripleA), in which these serines are mutated to alanine, suggesting that stimulation of RUNX1 trans-activation by cdk-mediated reduction in HDAC interaction increases marrow progenitor cell proliferation. Serine 239-246 runt related transcription factor 1 Mus musculus 9-14 21059642-7 2011 Finally, RUNX1 or RUNX1(tripleD), in which Ser-48, Ser-303, and Ser-424 are mutated to aspartic acid, stimulated proliferation of transduced, lineage-negative murine marrow progenitors more potently than did RUNX1(tripleA), in which these serines are mutated to alanine, suggesting that stimulation of RUNX1 trans-activation by cdk-mediated reduction in HDAC interaction increases marrow progenitor cell proliferation. Serine 239-246 runt related transcription factor 1 Mus musculus 18-23 21059642-7 2011 Finally, RUNX1 or RUNX1(tripleD), in which Ser-48, Ser-303, and Ser-424 are mutated to aspartic acid, stimulated proliferation of transduced, lineage-negative murine marrow progenitors more potently than did RUNX1(tripleA), in which these serines are mutated to alanine, suggesting that stimulation of RUNX1 trans-activation by cdk-mediated reduction in HDAC interaction increases marrow progenitor cell proliferation. Serine 239-246 runt related transcription factor 1 Mus musculus 18-23 21059642-7 2011 Finally, RUNX1 or RUNX1(tripleD), in which Ser-48, Ser-303, and Ser-424 are mutated to aspartic acid, stimulated proliferation of transduced, lineage-negative murine marrow progenitors more potently than did RUNX1(tripleA), in which these serines are mutated to alanine, suggesting that stimulation of RUNX1 trans-activation by cdk-mediated reduction in HDAC interaction increases marrow progenitor cell proliferation. Serine 239-246 runt related transcription factor 1 Mus musculus 18-23 18261462-2 2008 Based on transfection assays, phosphorylation of Runx1 at the three serine residues, Ser249, Ser266, and Ser276, was thought to be important for trans-activation activity of Runx1. Serine 68-74 runt related transcription factor 1 Mus musculus 49-54 18261462-2 2008 Based on transfection assays, phosphorylation of Runx1 at the three serine residues, Ser249, Ser266, and Ser276, was thought to be important for trans-activation activity of Runx1. Serine 68-74 runt related transcription factor 1 Mus musculus 174-179 18261462-3 2008 By using "knock-in" gene targeting, we generated mouse strains expressing mutant Runx1 protein that harbored a combined serine-to-alanine substitution at either of two residues, Ser249/Ser266 or Ser249/Ser276. Serine 120-126 runt related transcription factor 1 Mus musculus 81-86 18261462-6 2008 These results not only challenge the predicted regulation of Runx1 activity by phosphorylation at these serine residues, but also reaffirm the effectiveness of "knock-in" mutagenesis as a powerful tool for addressing the physiological relevance of post-translation modifications. Serine 104-110 runt related transcription factor 1 Mus musculus 61-66