PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34299059-8 2021 Dox (10 mg/kg) increased the cardiac tissue levels of 4-hydroxynonenal, NQO1, C-MYC, and DRP1 phosphorylation at serine 616, but these increases were not observed with vitamin D + Dox (10 mg/kg). Serine 113-119 dynamin 1-like Mus musculus 89-93 34618332-6 2022 We found that Drp1 phosphorylation at serine 616 in macrophages/microglia was decreased with Mdivi-1 treatment, which was accompanied by decreased antigen presentation capacity of the macrophages/microglia in the EAE mouse spinal cord. Serine 38-44 dynamin 1-like Mus musculus 14-18 34705256-13 2021 In addition, ogt knockdown markedly decreased serine 637 phosphorylation level of mitochondrial fission protein dynamin-related protein 1 (Drp1) and promoted Drp1 translocation from the cytosol to the mitochondria. Serine 46-52 dynamin 1-like Mus musculus 112-137 34705256-13 2021 In addition, ogt knockdown markedly decreased serine 637 phosphorylation level of mitochondrial fission protein dynamin-related protein 1 (Drp1) and promoted Drp1 translocation from the cytosol to the mitochondria. Serine 46-52 dynamin 1-like Mus musculus 139-143 32686869-7 2020 LPS triggered acute Drp1 phosphorylation at serine 635 (S635), followed by sustained Drp1 dephosphorylation at serine 656 (S656), in BMMs. Serine 44-50 dynamin 1-like Mus musculus 20-24 33080440-8 2020 Moreover, Stat2 boosts Drp1 phosphorylation at serine 616, required for Drp1-mediated mitochondrial fission. Serine 47-53 dynamin 1-like Mus musculus 23-27 33080440-8 2020 Moreover, Stat2 boosts Drp1 phosphorylation at serine 616, required for Drp1-mediated mitochondrial fission. Serine 47-53 dynamin 1-like Mus musculus 72-76 32686869-7 2020 LPS triggered acute Drp1 phosphorylation at serine 635 (S635), followed by sustained Drp1 dephosphorylation at serine 656 (S656), in BMMs. Serine 111-117 dynamin 1-like Mus musculus 85-89 32291286-6 2020 In the mouse model, PKCdelta was activated and accumulated in mitochondria, where it mediated phosphorylation of a mitochondrial fission protein, dynamin-related protein 1 (Drp1), at serine 616. Serine 183-189 dynamin 1-like Mus musculus 146-171 32291286-6 2020 In the mouse model, PKCdelta was activated and accumulated in mitochondria, where it mediated phosphorylation of a mitochondrial fission protein, dynamin-related protein 1 (Drp1), at serine 616. Serine 183-189 dynamin 1-like Mus musculus 173-177 31881179-3 2020 Here, we demonstrate that dynamin-related protein 1(DRP1) is a substrate for p38 MAPK, mutant alpha-synuclein overexpression in SN4741 cell caused p38 MAPK activation, p38 MAPK-mediated phosphorylation DRP1 at serine 616 to activate DRP1 and is associated with increased mitochondrial fission, which resulted in mitochondrial dysfunction and neuronal loss. Serine 210-216 dynamin 1-like Mus musculus 26-51 31881179-3 2020 Here, we demonstrate that dynamin-related protein 1(DRP1) is a substrate for p38 MAPK, mutant alpha-synuclein overexpression in SN4741 cell caused p38 MAPK activation, p38 MAPK-mediated phosphorylation DRP1 at serine 616 to activate DRP1 and is associated with increased mitochondrial fission, which resulted in mitochondrial dysfunction and neuronal loss. Serine 210-216 dynamin 1-like Mus musculus 52-56 31510791-9 2019 Hypoxia or 4-hydroxynonenal increased stabilization of HIF (hypoxia-inducible factor)-1alpha, phosphorylation of Drp1 (dynamin-related protein 1) at serine 616, mitochondrial fission, and pulmonary artery smooth muscle cells proliferation, whereas ALDH2 activation suppressed the latter 3. Serine 149-155 dynamin 1-like Mus musculus 113-117 31781748-0 2019 Quercetin improves endothelial insulin sensitivity in obese mice by inhibiting Drp1 phosphorylation at serine 616 and mitochondrial fragmentation. Serine 103-109 dynamin 1-like Mus musculus 79-83 31781748-6 2019 Mechanistically, quercetin specifically suppressed Drp1 phosphorylation at serine 616, whereas it showed little effects on the Drp1 level and its phosphorylation at serine 637 in cultured endothelial cells under oxidative stress. Serine 75-81 dynamin 1-like Mus musculus 51-55 31781748-7 2019 Furthermore, our results also showed that quercetin suppressed Drp1 phosphorylation at serine 616 by inhibiting PKCdelta as revealed by western blot analysis. Serine 87-93 dynamin 1-like Mus musculus 63-67 31510791-9 2019 Hypoxia or 4-hydroxynonenal increased stabilization of HIF (hypoxia-inducible factor)-1alpha, phosphorylation of Drp1 (dynamin-related protein 1) at serine 616, mitochondrial fission, and pulmonary artery smooth muscle cells proliferation, whereas ALDH2 activation suppressed the latter 3. Serine 149-155 dynamin 1-like Mus musculus 119-144 30404834-6 2018 The constrictions are accompanied by elevated phosphorylation of Drp1 (Dnm1l) at Ser 616, indicating an increased translocation of Drp1 to the mitochondrial membrane. Serine 81-84 dynamin 1-like Mus musculus 65-69 30404834-6 2018 The constrictions are accompanied by elevated phosphorylation of Drp1 (Dnm1l) at Ser 616, indicating an increased translocation of Drp1 to the mitochondrial membrane. Serine 81-84 dynamin 1-like Mus musculus 71-76 30404834-6 2018 The constrictions are accompanied by elevated phosphorylation of Drp1 (Dnm1l) at Ser 616, indicating an increased translocation of Drp1 to the mitochondrial membrane. Serine 81-84 dynamin 1-like Mus musculus 131-135 29209146-8 2017 Moreover, reducing ADRM1 levels enhanced activity of fission factor dynamin-related GTPase protein 1 (Drp1) via increased phosphorylation at serine 616 of Drp1 (Drp1Ser616). Serine 141-147 dynamin 1-like Mus musculus 102-106 28448247-8 2018 Furthermore, Ole amended a glutamate-induced mitochondrial dynamic imbalance and reduced the number of cells with fragmented mitochondria, regulating the phosphorylation of Drp1 at amino acid residue serine 637. Serine 200-206 dynamin 1-like Mus musculus 173-177 29397067-5 2018 Drp1 phosphorylation at serine 616 is increased in HD knock-in mouse derived striatal cells, which is abolished by treatment with U0126, a potent inhibitor of MEK1/2. Serine 24-30 dynamin 1-like Mus musculus 0-4 29209146-8 2017 Moreover, reducing ADRM1 levels enhanced activity of fission factor dynamin-related GTPase protein 1 (Drp1) via increased phosphorylation at serine 616 of Drp1 (Drp1Ser616). Serine 141-147 dynamin 1-like Mus musculus 155-159 29209146-8 2017 Moreover, reducing ADRM1 levels enhanced activity of fission factor dynamin-related GTPase protein 1 (Drp1) via increased phosphorylation at serine 616 of Drp1 (Drp1Ser616). Serine 141-147 dynamin 1-like Mus musculus 161-171 26247724-5 2015 DRP1 inhibition promotes RGC survival by increasing phosphorylation of Bad at serine 112 in the retina and preserves RGC axons by maintaining mt integrity in the glial lamina of glaucomatous D2 mice. Serine 78-84 dynamin 1-like Mus musculus 0-4 28623750-7 2017 Fission protein Drp1 and its ser 616 phosphorylation were also increased post DOX and which could be reduced by LCZ696. Serine 29-32 dynamin 1-like Mus musculus 16-20 28623750-8 2017 In vitro, increased cardiomyocyte apoptosis, Drp1 ser 616 phosphorylation post DOX stimulation could be significantly attenuated by LCZ696 or Drp1 specific inhibitor Midivi-1. Serine 50-53 dynamin 1-like Mus musculus 45-49 28623750-8 2017 In vitro, increased cardiomyocyte apoptosis, Drp1 ser 616 phosphorylation post DOX stimulation could be significantly attenuated by LCZ696 or Drp1 specific inhibitor Midivi-1. Serine 50-53 dynamin 1-like Mus musculus 142-146 25192600-3 2015 We identified glycogen synthase kinase (GSK)3beta-dependent Drp1 phosphorylation at Ser(40) and Ser(44), which increases Drp1 GTPase activity and its mitochondrial distribution and could induce mitochondrial fragmentation. Serine 84-87 dynamin 1-like Mus musculus 60-64 25192600-3 2015 We identified glycogen synthase kinase (GSK)3beta-dependent Drp1 phosphorylation at Ser(40) and Ser(44), which increases Drp1 GTPase activity and its mitochondrial distribution and could induce mitochondrial fragmentation. Serine 84-87 dynamin 1-like Mus musculus 121-125 25192600-3 2015 We identified glycogen synthase kinase (GSK)3beta-dependent Drp1 phosphorylation at Ser(40) and Ser(44), which increases Drp1 GTPase activity and its mitochondrial distribution and could induce mitochondrial fragmentation. Serine 96-99 dynamin 1-like Mus musculus 60-64 25192600-3 2015 We identified glycogen synthase kinase (GSK)3beta-dependent Drp1 phosphorylation at Ser(40) and Ser(44), which increases Drp1 GTPase activity and its mitochondrial distribution and could induce mitochondrial fragmentation. Serine 96-99 dynamin 1-like Mus musculus 121-125 23904108-4 2013 We found that differentiation of C2C12 myoblasts induced by serum starvation was accompanied by a gradual increase in Drp1 protein expression (to ~350% up to 3 days) and a fast reduction of Drp1 phosphorylation at Ser-637 (to ~30%) resulting in translocation of Drp1 protein from the cytosol to mitochondria. Serine 214-217 dynamin 1-like Mus musculus 190-194 23904108-4 2013 We found that differentiation of C2C12 myoblasts induced by serum starvation was accompanied by a gradual increase in Drp1 protein expression (to ~350% up to 3 days) and a fast reduction of Drp1 phosphorylation at Ser-637 (to ~30%) resulting in translocation of Drp1 protein from the cytosol to mitochondria. Serine 214-217 dynamin 1-like Mus musculus 190-194 22326220-6 2012 Importantly, we found that ROCK1 triggers mitochondrial fission by phosphorylating Drp1 at serine 600 residue. Serine 91-97 dynamin 1-like Mus musculus 83-87