PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22999956-4 2012 Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice. Serine 0-7 huntingtin Homo sapiens 72-82 15809304-3 2005 This neuroprotective effect involves the phosphorylation of huntingtin at Ser(421) by the prosurvival kinase Akt (Humbert, S., Bryson, E. A., Cordelieres, F. P., Connors, N. C., Datta, S. R., Finkbeiner, S., Greenberg, M. E., and Saudou, F. (2002) Dev. Serine 74-77 huntingtin Homo sapiens 60-70 19860865-6 2009 RESULTS: The phosphorylation of huntingtin at serine 421 (S421) restores its function in axonal transport. Serine 46-52 huntingtin Homo sapiens 32-42 18992820-1 2009 Huntingtin is phosphorylated on serine-421 (S421) by the pro-survival signaling protein kinases Akt and SGK. Serine 32-38 huntingtin Homo sapiens 0-10 18772195-2 2008 Here, we demonstrate that phosphorylation of htt at serine 421 (S421) restores its function in axonal transport. Serine 52-58 huntingtin Homo sapiens 45-48 20064390-0 2009 Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice. Serine 0-7 huntingtin Homo sapiens 72-82 18573880-5 2008 This requires profilin"s G-actin binding activity and its direct interaction with Htt, which are both inhibited by the ROCK1-mediated phosphorylation of profilin at Ser-137. Serine 165-168 huntingtin Homo sapiens 82-85 18615096-4 2008 Huntingtin is phosphorylated at serine 421 by the kinase Akt but the role of this modification is unknown. Serine 32-38 huntingtin Homo sapiens 0-10 17611284-4 2007 We show here that huntingtin is phosphorylated by the cyclin-dependent kinase 5 (Cdk5) at serines 1181 and 1201. Serine 90-97 huntingtin Homo sapiens 18-28 17611284-7 2007 Absence of phosphorylation of huntingtin at serines 1181 and 1201 confers toxic properties to wild-type huntingtin in a p53-dependent manner in striatal neurons and accelerates neuronal death induced by DNA damage. Serine 44-51 huntingtin Homo sapiens 30-40 24334607-5 2014 The ability to form one or the other type of inclusion can be influenced by the phosphorylation state of serine residues at amino acid positions 13 and 16 within the huntingtin protein. Serine 105-111 huntingtin Homo sapiens 166-176 14725621-0 2004 The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin. Serine 112-118 huntingtin Homo sapiens 65-75 14725621-0 2004 The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin. Serine 112-118 huntingtin Homo sapiens 126-136 14725621-3 2004 Indeed, upon IGF-1 activation, Akt phosphorylates polyQ-huntingtin at serine 421 and abrogates its toxicity. Serine 70-76 huntingtin Homo sapiens 56-66 14725621-6 2004 We show that SGK phosphorylates huntingtin at serine 421 and that phosphorylation can protect striatal neurons against polyQ-huntingtin-induced toxicity. Serine 46-52 huntingtin Homo sapiens 32-42 12062094-1 2002 In the search for neuroprotective factors in Huntington"s disease, we found that insulin growth factor 1 via activation of the serine/threonine kinase Akt/PKB is able to inhibit neuronal death specifically induced by mutant huntingtin containing an expanded polyglutamine stretch. Serine 127-133 huntingtin Homo sapiens 224-234 9466992-2 1998 We detected an interaction with cystathionine beta-synthase (CBS) [L-serine hydrolyase (adding homocysteine), EC 4.2.1.22], which was confirmed in vitro using His-tagged CBS expressed in Escherichia coli , which was able to specifically bind both rat and human full-length huntingtin. Serine 69-75 huntingtin Homo sapiens 273-283 32941796-5 2021 We ectopically expressed full-length (FL) and exon1 fragment of human HTT with phosphomimetic and resistant mutations at serines 13 and 16 in different neuronal populations. Serine 121-128 huntingtin Homo sapiens 70-73 30538129-7 2019 We also found that HMGB1 interacts with the huntingtin N17 region and that this interaction is enhanced by the presence of ROS and phosphorylation of critical serine residues in the N17 region. Serine 159-165 huntingtin Homo sapiens 44-54 25099302-2 2014 The Huntingtin (HTT) gene has been functionally linked to cortical brain-derived neurotrophic factor (BDNF) support of striatal MSNs via phosphorylation at serine 421. Serine 156-162 huntingtin Homo sapiens 4-14 25099302-2 2014 The Huntingtin (HTT) gene has been functionally linked to cortical brain-derived neurotrophic factor (BDNF) support of striatal MSNs via phosphorylation at serine 421. Serine 156-162 huntingtin Homo sapiens 16-19 25099302-7 2014 Mn exposure decreased serine 421 phosphorylation of Htt in cortical and hippocampal neurons and increased total Htt levels. Serine 22-28 huntingtin Homo sapiens 52-55 16471265-7 2005 This anti-apopototic effect is mediated via the phosphorylation of serine 421 of huntingtin. Serine 67-73 huntingtin Homo sapiens 81-91 32805086-2 2021 In particular, phosphorylation of threonine and serine residues (T3, S13, and/or S16) has been shown to inhibit Htt aggregation in vitro and inclusion formation in cellular and animal models of Huntington"s disease (HD). Serine 48-54 huntingtin Homo sapiens 112-115 24505464-0 2014 Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity. Serine 40-46 huntingtin Homo sapiens 26-36