PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34042026-7 2022 In this review, we discuss the current state of the art of developing inhibitors against the entry proteases furin, the transmembrane serine protease type-II (TMPRSS2), trypsin, and cathepsin L. Serine 134-140 transmembrane serine protease 2 Homo sapiens 159-166 33706067-1 2021 While the angiotensin converting enzyme 2 (ACE2) protein is defined as the primary severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor, the viral serine molecule might be mobilized by the host"s transmembrane protease serine subtype 2 (TMPRSS2) enzyme from the viral spike (S) protein and hijack the host"s N-acetyl-D-galactosamine (GalNAc) metabolism. Serine 164-170 transmembrane serine protease 2 Homo sapiens 254-261 34016183-8 2021 Previous studies have shown that people with ACE2 polymorphism who have type 2 transmembrane serine proteases (TMPRSS2) are at high risk of SARS-CoV-2 infection. Serine 93-99 transmembrane serine protease 2 Homo sapiens 111-118 34001215-3 2021 Camostat mesylate acts as an inhibitor of the host cell serine protease TMPRSS2 and prevents the virus from entering the cell. Serine 56-62 transmembrane serine protease 2 Homo sapiens 72-79 33556871-3 2021 Meanwhile, host-targeted drugs that inhibit cellular transmembrane serine protease (TMPRSS2) can prevent SARS-CoV-2 from entering cells, and its combination with chloroquine and dihydroorotate dehydrogenase (DHODH) inhibitors can limit the spread of SARS-CoV-2 and reduce the morbidity and mortality of patients with COVID-19. Serine 67-73 transmembrane serine protease 2 Homo sapiens 84-91 33996911-1 2021 Camostat, nafamostat, and bromhexine are inhibitors of the transmembrane serine protease TMPRSS2. Serine 73-79 transmembrane serine protease 2 Homo sapiens 89-96 32936429-4 2021 A tentative hypothesis to explain these findings is the role of angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2 involved in viral infection. Serine 107-113 transmembrane serine protease 2 Homo sapiens 123-130 33394891-3 2021 SARS-CoV-2 enters host cells via angiotensin converting enzyme-2 (ACE2) and the serine protease TMPRSS2. Serine 80-86 transmembrane serine protease 2 Homo sapiens 96-103 33991451-2 2021 Viral entry is dependent on the binding of the viral spike protein to the angiotensin converting enzyme II protein (ACE2) on the host cell surface, followed by proteolytic cleavage by a host serine protease such as TMPRSS2. Serine 191-197 transmembrane serine protease 2 Homo sapiens 215-222 33164230-10 2021 There is growing evidence that androgen-enabled expression of ACE2 receptors and the serine protease TMPRSS2, two permissive elements engaging the SARS-CoV-2 spike protein for infection, may contribute to severe COVID-19 in men. Serine 85-91 transmembrane serine protease 2 Homo sapiens 101-108 33969249-2 2021 Transmembrane serine protease 2 (TMPRSS2) is regarded as one of the main proteases implicated in the coronavirus S protein priming, an important step for binding of the S protein to the angiotensin-converting enzyme 2 (ACE2) receptor before cell entry. Serine 14-20 transmembrane serine protease 2 Homo sapiens 33-40 33969249-5 2021 Results: We identified the human extracellular serine protease inhibitor (serpin) alpha 1 anti-trypsin (A1AT) as a novel TMPRSS2 inhibitor. Serine 47-53 transmembrane serine protease 2 Homo sapiens 121-128 33969249-6 2021 Structural modeling revealed that A1AT docked to an extracellular domain of TMPRSS2 in a conformation that is suitable for catalysis, resembling similar serine protease inhibitor complexes. Serine 153-159 transmembrane serine protease 2 Homo sapiens 76-83 33609069-8 2021 Analyses of functional annotation and enrichment in TMPRSS2 showed that TMPRSS2 is mostly enriched in regulation of viral entry into host cells, protein processing and serine-type peptidase activity. Serine 168-174 transmembrane serine protease 2 Homo sapiens 52-59 33609069-8 2021 Analyses of functional annotation and enrichment in TMPRSS2 showed that TMPRSS2 is mostly enriched in regulation of viral entry into host cells, protein processing and serine-type peptidase activity. Serine 168-174 transmembrane serine protease 2 Homo sapiens 72-79 33188579-4 2021 Angiotensin-converting enzyme 2 (ACE2) and type II transmembrane serine protease (TMPRSS2) are the main host cell factors for the Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) entry but so far it is unclear if human MSCs express or do not these two proteins. Serine 65-71 transmembrane serine protease 2 Homo sapiens 82-89 33741941-5 2021 We further demonstrate that alpha1AT binds and inactivates the serine protease TMPRSS2, which enzymatically primes the SARS-CoV-2 spike protein for membrane fusion. Serine 63-69 transmembrane serine protease 2 Homo sapiens 79-86 33626084-6 2021 This pattern of ACE2 expression contrasted with that of transmembrane protease serine type 2 (TMPRSS2), which was significantly increased in full-term newborn and adult NHP lungs compared to preterm NHP lungs. Serine 79-85 transmembrane serine protease 2 Homo sapiens 94-101 33671076-2 2021 Although TMPRSS2 is a well-characterized type II transmembrane serine protease (TTSP), the role of other TTSPs on the replication of SARS-CoV-2 remains to be elucidated. Serine 63-69 transmembrane serine protease 2 Homo sapiens 9-16 33791156-1 2021 Transmembrane serine protease (TMPRSS2) plays an oncogenic role in prostate cancer as the fusion gene with ERG, and has also been demonstrated to be essential for the cellular entry of severe acute respiratory syndrome coronaviruses (SARS-CoV). Serine 14-20 transmembrane serine protease 2 Homo sapiens 31-38 33564221-1 2021 The type II transmembrane serine protease TMPRSS2 facilitates the entry of coronaviruses, such as SARS-CoV-2, into host cells by cleaving the S1/S2 interface of the viral spike protein. Serine 26-32 transmembrane serine protease 2 Homo sapiens 42-49 33570381-5 2021 However, we observed a substantial drop in antiviral potency upon expression of TMPRSS2, a transmembrane serine protease that acts in an alternative viral entry pathway to the lysosomal cathepsins. Serine 105-111 transmembrane serine protease 2 Homo sapiens 80-87 33488517-9 2020 ACE2 receptor and TMPRSS2 serine protease were colocalized in adrenocortical cells in zona fasciculata and zona reticularis. Serine 26-32 transmembrane serine protease 2 Homo sapiens 18-25 33130280-7 2021 The catalytic triad consisting of Serine-441, Histidine-296 and Aspartic acid-345 was identified as active binding site of TMPRSS2 using existing ligands. Serine 34-40 transmembrane serine protease 2 Homo sapiens 123-130 33098835-6 2021 Bioactive peptides with unique amino acid sequences can mitigate such targets including, type II transmembrane serine proteases (TMPRSS2) inhibition, furin cleavage, and renin-angiotensin-aldosterone system (RAAS) members. Serine 111-117 transmembrane serine protease 2 Homo sapiens 129-136 33035337-4 2021 SARS-CoV-2 uses human angiotensin-converting enzyme 2 (ACE2) for viral entry and transmembrane serine protease family member II (TMPRSS2) for spike protein priming. Serine 95-101 transmembrane serine protease 2 Homo sapiens 129-136 32808185-3 2020 Angiotensin-converting enzyme 2 (ACE2) and Transmembrane serine protease (TMPRSS2) are the main cell entry receptors of SARS-CoV-2. Serine 57-63 transmembrane serine protease 2 Homo sapiens 74-81 33397514-5 2021 Interestingly, serine protease transmembrane serine protease 2 (TMPRSS2) had less expression in cardiomyocytes, but CTSB and CTSL, which belonged to cell protease, could be found to be enriched in cardiomyocytes. Serine 15-21 transmembrane serine protease 2 Homo sapiens 64-71 33397514-5 2021 Interestingly, serine protease transmembrane serine protease 2 (TMPRSS2) had less expression in cardiomyocytes, but CTSB and CTSL, which belonged to cell protease, could be found to be enriched in cardiomyocytes. Serine 45-51 transmembrane serine protease 2 Homo sapiens 64-71 33141332-3 2021 The current body of evidence indicates that SARS-CoV-2 requires the membrane-bound angiotensin-converting enzyme 2 (ACE2) and the membrane-bound serine protease TMPRSS2 to enter cells. Serine 145-151 transmembrane serine protease 2 Homo sapiens 161-168 33382023-11 2020 Significant decrease in TMPRSS2-Fisetin and TMPRSS2-Nafamostat complex fluctuation occurred around His 41, Glu 44, Gly 136, Ser 186 in RMSF study. Serine 124-127 transmembrane serine protease 2 Homo sapiens 24-31 33382023-11 2020 Significant decrease in TMPRSS2-Fisetin and TMPRSS2-Nafamostat complex fluctuation occurred around His 41, Glu 44, Gly 136, Ser 186 in RMSF study. Serine 124-127 transmembrane serine protease 2 Homo sapiens 44-51 33505639-0 2021 Spontaneous binding of potential COVID-19 drugs (Camostat and Nafamostat) to human serine protease TMPRSS2. Serine 83-89 transmembrane serine protease 2 Homo sapiens 99-106 33290397-2 2020 The host serine protease TMPRSS2 and cysteine proteases Cathepsin B/L can activate S, making two independent entry pathways accessible to SARS-CoV-2. Serine 9-15 transmembrane serine protease 2 Homo sapiens 25-32 33278189-4 2020 The virus requires proteolytic processing of its spike protein by transmembrane protease receptor serine type 2 (TMPRSS2) to enable binding to cellular ACE2. Serine 98-104 transmembrane serine protease 2 Homo sapiens 113-120 33415017-1 2020 The cell surface protein TMPRSS2 (transmembrane protease serine 2) is an androgen-responsive serine protease important for prostate cancer progression and therefore an attractive therapeutic target. Serine 57-63 transmembrane serine protease 2 Homo sapiens 25-32 32452644-2 2021 The key steps of virus life cycle have been recently clarified, highlighting the role of host type 2 angiotensin-converting enzyme (ACE2) and TMPRSS2 serine protease in virus-cell binding and entry, respectively. Serine 150-156 transmembrane serine protease 2 Homo sapiens 142-149 32972339-6 2021 The priming of the spike (S) protein of the virus by proteolytic cleavage by the trans-membrane serine protease-2 (TMPRSS2) is necessary for fusion of the virus to the host cell after it binds to its receptor angiotensin converting enzyme-2 (ACE2). Serine 96-102 transmembrane serine protease 2 Homo sapiens 115-122 33239231-5 2021 First, AAT is a serine protease inhibitor (SERPIN) shown to inhibit TMPRSS-2, the host serine protease that cleaves the spike protein of SARS-CoV-2, a necessary preparatory step for the virus to bind its cell surface receptor ACE2 to gain intracellular entry. Serine 16-22 transmembrane serine protease 2 Homo sapiens 68-76 33239231-5 2021 First, AAT is a serine protease inhibitor (SERPIN) shown to inhibit TMPRSS-2, the host serine protease that cleaves the spike protein of SARS-CoV-2, a necessary preparatory step for the virus to bind its cell surface receptor ACE2 to gain intracellular entry. Serine 87-93 transmembrane serine protease 2 Homo sapiens 68-76 33372179-4 2020 Since AT2 cells express the SARS-CoV-2 receptors angiotensin converting enzyme (ACE2) and transmembrane protease/serine subfamily member 2 (TMPRSS2), their expression should decline as AT2 cells are depleted by hyperoxia. Serine 113-119 transmembrane serine protease 2 Homo sapiens 140-147 33375616-1 2020 The human serine protease serine 2 TMPRSS2 is involved in the priming of proteins of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and represents a possible target for COVID-19 therapy. Serine 10-16 transmembrane serine protease 2 Homo sapiens 35-42 33375616-1 2020 The human serine protease serine 2 TMPRSS2 is involved in the priming of proteins of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and represents a possible target for COVID-19 therapy. Serine 26-32 transmembrane serine protease 2 Homo sapiens 35-42 33328008-2 2020 Angiotensin-converting enzyme 2 (ACE2), one of the binding sites for SARS-CoV-2 infection in humans, can bind to viral spike proteins, allowing transmembrane serine protease (TMPRSS2) to activate S-protein to trigger infection and induce the production of various inflammatory factors such as interleukin-1, interferon-l, and tumor necrosis factor. Serine 158-164 transmembrane serine protease 2 Homo sapiens 175-182 33391794-1 2020 Angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2 have been implicated in cell entry for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). Serine 43-49 transmembrane serine protease 2 Homo sapiens 59-66 33218024-0 2020 Target-Centered Drug Repurposing Predictions of Human Angiotensin-Converting Enzyme 2 (ACE2) and Transmembrane Protease Serine Subtype 2 (TMPRSS2) Interacting Approved Drugs for Coronavirus Disease 2019 (COVID-19) Treatment through a Drug-Target Interaction Deep Learning Model. Serine 120-126 transmembrane serine protease 2 Homo sapiens 138-145 32890967-3 2020 SARS-CoV-2 entry into host cells is characterized by viral spike protein interaction with cellular angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2. Serine 142-148 transmembrane serine protease 2 Homo sapiens 158-165 32857620-11 2020 CONCLUSIONS: This proof of concept demonstrates azithromycin downregulates pathways involving serine proteases TMPRSS2 and TMPRSS11D required for SARS-CoV-2 activation and its cell-to-cell transmission while downregulating pro-inflammatory cytokine IL-1beta, NDST-1 and their associated pathways. Serine 94-100 transmembrane serine protease 2 Homo sapiens 111-118 32829149-8 2020 We highlight 376 approved, investigational or experimental drugs targeting S1A serine proteases that may also inhibit TMPRSS2. Serine 79-85 transmembrane serine protease 2 Homo sapiens 118-125 32441816-4 2020 Therefore, this study aimed to assess the presence of angiotensin-converting enzyme 2 (ACE2)/transmembrane serine proteases 2 (TMPRSS2) expression in salivary glands using publicly available databases. Serine 107-113 transmembrane serine protease 2 Homo sapiens 127-134 32960480-4 2020 The plasma serine protease inhibitor alpha-1 antitrypsin was suggested to protect from COVID-19 by inhibiting TMPRSS2, a cell surface serine protease essential for the SARS-CoV-2 cell entry. Serine 11-17 transmembrane serine protease 2 Homo sapiens 110-117 32960480-4 2020 The plasma serine protease inhibitor alpha-1 antitrypsin was suggested to protect from COVID-19 by inhibiting TMPRSS2, a cell surface serine protease essential for the SARS-CoV-2 cell entry. Serine 134-140 transmembrane serine protease 2 Homo sapiens 110-117 32829149-10 2020 We discuss how experimental drugs targeting related serine proteases might be repurposed as TMPRSS2 inhibitors to treat coronaviruses. Serine 52-58 transmembrane serine protease 2 Homo sapiens 92-99 33137894-3 2020 The TMPRSS2 gene encodes a Transmembrane Protease Serine-2 protein (TMPS2) that belongs to the serine protease family. Serine 50-56 transmembrane serine protease 2 Homo sapiens 4-11 33125431-1 2020 Angiotensin-converting enzyme 2 (ACE2) has been implicated in the pathogenesis of chronic kidney disease (CKD) and is a membrane receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease (COVID-19), whereas transmembrane protease, serine 2 (TMPRSS2) is involved in viral attachment. Serine 294-300 transmembrane serine protease 2 Homo sapiens 304-311 33137894-3 2020 The TMPRSS2 gene encodes a Transmembrane Protease Serine-2 protein (TMPS2) that belongs to the serine protease family. Serine 50-56 transmembrane serine protease 2 Homo sapiens 68-73 33137894-3 2020 The TMPRSS2 gene encodes a Transmembrane Protease Serine-2 protein (TMPS2) that belongs to the serine protease family. Serine 95-101 transmembrane serine protease 2 Homo sapiens 4-11 33137894-3 2020 The TMPRSS2 gene encodes a Transmembrane Protease Serine-2 protein (TMPS2) that belongs to the serine protease family. Serine 95-101 transmembrane serine protease 2 Homo sapiens 68-73 33052338-2 2020 Transmembrane serine protease 2 (TMPRSS2) is regarded as one of the main proteases implicated in the coronavirus S protein priming, an important step for binding of the S protein to the angiotensin-converting enzyme 2 (ACE2) receptor before cell entry. Serine 14-20 transmembrane serine protease 2 Homo sapiens 33-40 32768580-3 2020 This study investigates the N720D variant, positioned in the collectrin-like domain (CLD) at proximity to type II transmembrane serine protease (TMPRSS2) cleavage site. Serine 128-134 transmembrane serine protease 2 Homo sapiens 145-152 33052338-4 2020 Herein, we identified the human extracellular serine protease inhibitor (serpin) alpha 1 antitrypsin (A1AT) as a novel TMPRSS2 inhibitor. Serine 46-52 transmembrane serine protease 2 Homo sapiens 119-126 33052338-5 2020 Structural modeling revealed that A1AT docked to an extracellular domain of TMPRSS2 in a conformation that is suitable for catalysis, resembling similar serine protease-inhibitor complexes. Serine 153-159 transmembrane serine protease 2 Homo sapiens 76-83 32730844-3 2020 A putative target to interfere with the virus is the host transmembrane serine protease family member II (TMPRSS2). Serine 72-78 transmembrane serine protease 2 Homo sapiens 106-113 32730844-5 2020 Repositioning approved, investigational and experimental drugs on the serine protease domain of TMPRSS2 could thus be valuable. Serine 70-76 transmembrane serine protease 2 Homo sapiens 96-103 33193689-1 2020 Type 2 transmembrane serine protease (TMPRSS2) is a new member of the serine proteases, and studies have shown that TMPRSS2 plays a role in the occurrence of prostate malignancies and is closely related to the occurrence of the coronavirus disease 2019 (COVID-19). Serine 21-27 transmembrane serine protease 2 Homo sapiens 38-45 33193689-1 2020 Type 2 transmembrane serine protease (TMPRSS2) is a new member of the serine proteases, and studies have shown that TMPRSS2 plays a role in the occurrence of prostate malignancies and is closely related to the occurrence of the coronavirus disease 2019 (COVID-19). Serine 21-27 transmembrane serine protease 2 Homo sapiens 116-123 33193689-1 2020 Type 2 transmembrane serine protease (TMPRSS2) is a new member of the serine proteases, and studies have shown that TMPRSS2 plays a role in the occurrence of prostate malignancies and is closely related to the occurrence of the coronavirus disease 2019 (COVID-19). Serine 70-76 transmembrane serine protease 2 Homo sapiens 38-45 33193689-1 2020 Type 2 transmembrane serine protease (TMPRSS2) is a new member of the serine proteases, and studies have shown that TMPRSS2 plays a role in the occurrence of prostate malignancies and is closely related to the occurrence of the coronavirus disease 2019 (COVID-19). Serine 70-76 transmembrane serine protease 2 Homo sapiens 116-123 32664949-4 2020 It is cleaved by type II transmembrane serine protease (TMPRSS)2 and disintegrin and metallopeptidase domain (ADAM)17 to assist viral entry into host cells. Serine 39-45 transmembrane serine protease 2 Homo sapiens 56-64 32992731-2 2020 Proposed mechanisms involve host cell membrane-bound angiotensin-converting enzyme 2 (ACE2), type II transmembrane serine proteases (TTSPs), such as transmembrane serine protease isoform 2 (TMPRSS2), lysosomal endopeptidase Cathepsin L (CTSL), subtilisin-like proprotein peptidase furin (FURIN), and even potentially membrane bound heparan sulfate proteoglycans. Serine 115-121 transmembrane serine protease 2 Homo sapiens 190-197 32992731-2 2020 Proposed mechanisms involve host cell membrane-bound angiotensin-converting enzyme 2 (ACE2), type II transmembrane serine proteases (TTSPs), such as transmembrane serine protease isoform 2 (TMPRSS2), lysosomal endopeptidase Cathepsin L (CTSL), subtilisin-like proprotein peptidase furin (FURIN), and even potentially membrane bound heparan sulfate proteoglycans. Serine 163-169 transmembrane serine protease 2 Homo sapiens 190-197 32726128-5 2020 Testosterone on the contrary enhances the levels of the two most critical molecules, angiotensin-converting enzyme 2 (ACE2) and the transmembrane protease serine-type 2 (TMPRSS2), transcriptionally and posttranslationally, thereby increasing viral load and delaying viral clearance in men as compared with women. Serine 155-161 transmembrane serine protease 2 Homo sapiens 170-177 33042994-8 2020 Following the binding of the S1 receptor-binding domain (RBD) to ACE2, transmembrane protease/serine subfamily 2 (TMPRSS2) cleaves the S2 domain to facilitate membrane fusion. Serine 94-100 transmembrane serine protease 2 Homo sapiens 114-121 32641482-7 2020 Interestingly, overexpression of serine protease TMPRSS2 or amphotericin treatment significantly neutralized the IFN-inducible transmembrane 3 (IFITM3) restriction of human coronavirus (CoV) entry, but did not compromise the effect of LY6E on the entry of human coronaviruses. Serine 33-39 transmembrane serine protease 2 Homo sapiens 49-56 32741259-3 2020 SARS-CoV and SARS-CoV-2 employ the host cellular serine protease TMPRSS2 for spike (S) protein priming for viral entry into host cells. Serine 49-55 transmembrane serine protease 2 Homo sapiens 65-72 32638018-7 2020 Inversely, the most important S protein cleavage protease TMPRSS2 (transmembrane protease serine protease-2) in the heart exhibits an extremely lower expression than that in the lung (adjusted P < 0.0001), which may restrict entry of SARS-CoV-2 into cardiac cells. Serine 90-96 transmembrane serine protease 2 Homo sapiens 58-65 32864545-5 2020 Androgens upregulate the protease TMPRSS2 (type II transmembrane serine protease-2), which facilitates efficient virus-host cell fusion with the epithelium of the lungs, thus increasing susceptibility to SARS-CoV-2 infection and development of severe COVID-19. Serine 65-71 transmembrane serine protease 2 Homo sapiens 34-41 32743585-4 2020 Because AT2 cells express the SARS-CoV-2 receptors angiotensin converting enzyme (ACE2) and transmembrane protease/serine subfamily member 2 (TMPRSS2), we expected their expression would decline as AT2 cells were depleted by hyperoxia. Serine 115-121 transmembrane serine protease 2 Homo sapiens 142-149 32672528-1 2021 Transmembrane serine protease 2 (TMPRSS2) has been established as one of the host proteins that facilitate entry of coronaviruses into host cells. Serine 14-20 transmembrane serine protease 2 Homo sapiens 33-40 32662421-3 2020 The novel coronavirus canonically utilizes the angiotensin-converting enzyme 2 (ACE2) receptor and the serine protease TMPRSS2 for cell entry. Serine 103-109 transmembrane serine protease 2 Homo sapiens 119-126 32412310-2 2020 Prostate cancer is one of the most common cancers among men and raises particular interest during the pandemic as recent reports show that the TMPRSS2 (and other serine proteases), which facilitate the entry, replication and budding of the virion from a cell, can be inhibited using androgen deprivation therapy. Serine 162-168 transmembrane serine protease 2 Homo sapiens 143-150 32278065-8 2020 SARS-CoV uses the angiotensin-converting enzyme 2 (ACE2) and the serine protease TMPRSS2 for S protein priming. Serine 65-71 transmembrane serine protease 2 Homo sapiens 81-88 32589459-1 2020 PURPOSE: The spike proteins of SARS-CoV-2 interact with ACE2 or basigin/CD147 receptors, regulating human-to-human transmissions of COVID-19 together with serine protease TMPRSS2. Serine 155-161 transmembrane serine protease 2 Homo sapiens 171-178 32360480-4 2020 Such drugs comprise inhibitors of TMPRSS2 serine protease and inhibitors of angiotensin-converting enzyme 2 (ACE2). Serine 42-48 transmembrane serine protease 2 Homo sapiens 34-41 32572552-3 2020 The current body of evidence indicates that SARS-CoV-2 requires the membrane-bound angiotensin-converting enzyme 2 (ACE2) and the membrane-bound serine protease TMPRSS2 to enter cells. Serine 145-151 transmembrane serine protease 2 Homo sapiens 161-168 32574273-12 2020 Finally, a direct effect of GL or GA to reduce virus transmission exists, which may involve reduced expression of type 2 transmembrane serine protease (TMPRSS2), which is required for virus uptake. Serine 135-141 transmembrane serine protease 2 Homo sapiens 152-159 32582302-4 2020 The SARS-CoV-2 virus responsible for the infection depends on two human genes: the human receptor angiotensin converting enzyme 2 (ACE2) for cell invasion, and the serine protease TMPRSS2 for S protein priming. Serine 164-170 transmembrane serine protease 2 Homo sapiens 180-187 32410502-2 2021 TMPRSS2 encodes a transmembrane serine protease which plays a crucial role in SARS-CoV-2 cell entry. Serine 32-38 transmembrane serine protease 2 Homo sapiens 0-7 32595355-4 2020 One of the important SARS-CoV-2 targets namely type 2 transmembrane serine protease (TMPRSS2) was screened with NPC"s NIH small molecule library which includes approved drugs by FDA and compounds in clinical investigation. Serine 68-74 transmembrane serine protease 2 Homo sapiens 85-92 32574272-5 2020 Host proteases, e.g., cathepsins, furin, or members of the type II transmembrane serine proteases (TTSP) family, such as Transmembrane protease serine 2 (TMPRSS2), are involved in virus entry by proteolytically activating virus ligands. Serine 81-87 transmembrane serine protease 2 Homo sapiens 121-152 32574272-5 2020 Host proteases, e.g., cathepsins, furin, or members of the type II transmembrane serine proteases (TTSP) family, such as Transmembrane protease serine 2 (TMPRSS2), are involved in virus entry by proteolytically activating virus ligands. Serine 81-87 transmembrane serine protease 2 Homo sapiens 154-161 32408547-0 2020 Virtual Screening of Natural Products against Type II Transmembrane Serine Protease (TMPRSS2), the Priming Agent of Coronavirus 2 (SARS-CoV-2). Serine 68-74 transmembrane serine protease 2 Homo sapiens 85-92 32325025-3 2020 (Cell) identify ACE2 as a SARS-CoV-2 receptor, and the latter show its entry mechanism depends on cellular serine protease TMPRSS2. Serine 107-113 transmembrane serine protease 2 Homo sapiens 123-130 32404436-4 2020 Expression of two mucosa-specific serine proteases, TMPRSS2 and TMPRSS4, facilitated SARS-CoV-2 spike fusogenic activity and promoted virus entry into host cells. Serine 34-40 transmembrane serine protease 2 Homo sapiens 52-59 32511288-2 2020 We have focused on identifying repurposing candidates for the transmembrane serine protease family member II (TMPRSS2), which is critical for entry of coronaviruses into cells. Serine 76-82 transmembrane serine protease 2 Homo sapiens 110-117 32376987-2 2020 The transmembrane serine protease TMPRSS2 was previously identified as the essential protease that can cleave hemagglutinin of many subtypes of influenza virus and spike protein of coronavirus. Serine 18-24 transmembrane serine protease 2 Homo sapiens 34-41 32142651-4 2020 Here, we demonstrate that SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming. Serine 87-93 transmembrane serine protease 2 Homo sapiens 103-110 32661206-3 2020 Cellular receptor ACE2, serine protease TMPRSS2 and exopeptidase CD26 (also known as DPP4) are the three membrane bound proteins potentially implicated in SARS-CoV-2 infection. Serine 24-30 transmembrane serine protease 2 Homo sapiens 40-47 32985199-4 2020 SARS-CoV-2 has been shown to use the SARS-CoV receptor ACE2 for entry and serine protease TMPRSS2 for S protein priming. Serine 74-80 transmembrane serine protease 2 Homo sapiens 90-97 11741986-7 2002 The sequence of the protease domain carried the essential triad His, Asp, and Ser and showed some similarity to that of TMPRSS2, hepsin, HAT, MT-SP1, TMPRSS3, and corin, sharing 45.5, 41.9, 41.3, 40.3, 39.1, and 38.5% identity, respectively. Serine 78-81 transmembrane serine protease 2 Homo sapiens 120-127 30626688-1 2019 Transmembrane serine protease TMPRSS2 activates the spike protein of highly pathogenic human coronaviruses such as severe acute respiratory syndrome-related coronavirus (SARS-CoV) and Middle East respiratory syndrome-related coronavirus (MERS-CoV). Serine 14-20 transmembrane serine protease 2 Homo sapiens 30-37 30626688-10 2019 Transmembrane protease serine type 2 (TMPRSS2), a protease belonging to the type II transmembrane serine protease family, cleaves the coronavirus spike protein, making it a potential therapeutic target for coronavirus infections. Serine 23-29 transmembrane serine protease 2 Homo sapiens 38-45 30626688-10 2019 Transmembrane protease serine type 2 (TMPRSS2), a protease belonging to the type II transmembrane serine protease family, cleaves the coronavirus spike protein, making it a potential therapeutic target for coronavirus infections. Serine 98-104 transmembrane serine protease 2 Homo sapiens 38-45 33824725-1 2021 SARS-CoV-2 utilizes the angiotensin-converting enzyme 2 (ACE2) receptor and transmembrane serine protease (TMPRSS2) to infect human lung cells. Serine 90-96 transmembrane serine protease 2 Homo sapiens 107-114 33972944-4 2021 Attractive pharmacological targets to impede viral entry include type-II transmembrane serine proteases (TTSPs), such as TMPRSS2, whose essential role in the virus lifecycle is responsible for the cleavage and priming of the viral spike protein 5-7 . Serine 87-93 transmembrane serine protease 2 Homo sapiens 121-128 33762412-0 2021 Host serine proteases TMPRSS2 and TMPRSS11D mediate proteolytic activation and trypsin-independent infection in group A rotaviruses. Serine 5-11 transmembrane serine protease 2 Homo sapiens 22-29 34915414-1 2022 The interactions of four sulfonylated Phe(3-Am)-derived inhibitors (MI-432, MI-463, MI-482 and MI-1900) of type II transmembrane serine proteases (TTSP) such as transmembrane protease serine 2 (TMPRSS2) were examined with serum albumin and cytochrome P450 (CYP) isoenzymes. Serine 129-135 transmembrane serine protease 2 Homo sapiens 161-192 34915414-1 2022 The interactions of four sulfonylated Phe(3-Am)-derived inhibitors (MI-432, MI-463, MI-482 and MI-1900) of type II transmembrane serine proteases (TTSP) such as transmembrane protease serine 2 (TMPRSS2) were examined with serum albumin and cytochrome P450 (CYP) isoenzymes. Serine 129-135 transmembrane serine protease 2 Homo sapiens 194-201 34915500-2 2022 This study elucidates pulmonary expression patterns SARS-CoV-2 entry factors (ACE2 and transmembrane protease serine subtype 2, TMPRSS2) and RAAS components in lethal COVID-19. Serine 110-116 transmembrane serine protease 2 Homo sapiens 128-135 34826419-2 2022 Its infection depends on the binding of spike protein to the host cell receptor angiotensin-converting enzyme 2 (ACE2), type II transmembrane serine protease (TMPRSS2) and neuropilin-1 (NRP1). Serine 142-148 transmembrane serine protease 2 Homo sapiens 159-166 34561887-5 2022 The viral particle incorporates the S protein, which has already undergone S1/S2 cleavage by furin, and then undergoes further cleavage at the S2" site, mediated by the type II transmembrane serine protease TMPRSS2, after binding to the receptor ACE2 to facilitate membrane fusion at the plasma membrane. Serine 191-197 transmembrane serine protease 2 Homo sapiens 207-214 34635581-1 2021 The host cell serine protease TMPRSS2 is an attractive therapeutic target for COVID-19 drug discovery. Serine 14-20 transmembrane serine protease 2 Homo sapiens 30-37 34913352-2 2021 In the lower respiratory system, the virus uses angiotensin-converting enzyme 2 (ACE2) receptor in conjunction with serine protease TMPRSS2, expressed by alveolar type II (ATII) cells as one of the SARS-CoV-2 target cells, to enter. Serine 116-122 transmembrane serine protease 2 Homo sapiens 132-139 34606834-4 2021 Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease/serine subfamily member 2 (TMPRSS2) are essential proteins involved in the cell entry of SARS-CoV-2. Serine 66-72 transmembrane serine protease 2 Homo sapiens 93-100 34875734-2 2021 The virus enters host cells through angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine subtype 2 (TMPRSS2). Serine 102-108 transmembrane serine protease 2 Homo sapiens 120-127 34677831-3 2021 SARS-CoV-2 initially infects respiratory tract epithelial cells by binding to the host cell membrane ACE2, followed by proteolytic priming for cell entry by the host cell membrane serine protease TMPRSS2. Serine 180-186 transmembrane serine protease 2 Homo sapiens 196-203 34406864-15 2021 This study revealed that transmembrane protease serine S1, members 2 (TMPRSS2), and not human airway trypsin-like protease (HAT), is involved in HE cleavage. Serine 48-54 transmembrane serine protease 2 Homo sapiens 70-77 34132421-2 2021 The virus enters into humans by attachment of its Spike protein (S) to the ACE receptor present on the lung epithelial cell surface followed by cleavage of S protein by the cellular transmembrane serine protease (TMPRSS2). Serine 196-202 transmembrane serine protease 2 Homo sapiens 213-220 34635175-1 2021 BACKGROUND: SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) and neuropilin-1 (NRP1) receptors for entry into cells, and the serine protease TMPRSS2 for S protein priming. Serine 135-141 transmembrane serine protease 2 Homo sapiens 151-158 34393265-4 2021 Here, we performed a theoretical investigation of the same by studying the binding of the molecules with SARS-COV-2 Spike protein, the complex formed by Spike and ACE2 human receptor and a human serine protease TMPRSS2 which aids in cleavage of the Spike protein to initiate the viral activation in the body. Serine 195-201 transmembrane serine protease 2 Homo sapiens 211-218 34527703-5 2021 To help the virus enter efficiently, the S protein is further activated by the serine protease 2 (TMPRSS2), provided that the S has been cleaved by furin previously. Serine 79-85 transmembrane serine protease 2 Homo sapiens 98-105 34576032-4 2021 Differentiated iCMs expressed the primary SARS-CoV2 receptor angiotensin-converting enzyme-II (ACE2) and the transmembrane protease serine type 2 (TMPRSS2) receptor suggesting the susceptibility of iCMs to SARS-CoV2. Serine 132-138 transmembrane serine protease 2 Homo sapiens 147-154 34449057-2 2021 Interestingly, identified mutations mainly occur in the spike (S) protein which interacts with the ACE2 receptor and is cleaved via serine protease TMPRSS2. Serine 132-138 transmembrane serine protease 2 Homo sapiens 148-155 34160253-0 2021 Structural basis of covalent inhibitory mechanism of TMPRSS2-related serine proteases by camostat. Serine 69-75 transmembrane serine protease 2 Homo sapiens 53-60 34392451-7 2021 However, type II transmembrane serine protease (TMPRSS2) is able to inhibit the ENaC, but it is utilized in the case of SARS-CoV-2 cell entry, therefore the ENaC remains activated. Serine 31-37 transmembrane serine protease 2 Homo sapiens 48-55 34181691-4 2021 The serine protease TMPRSS2 has been shown to be important for S protein priming and viral entry, however, little is known about its regulation. Serine 4-10 transmembrane serine protease 2 Homo sapiens 20-27 34353250-4 2022 Studies suggests SARS-CoV-2 entry via olfactory epithelium (OE) and the expression of type 2 transmembrane serine protease (TMPRSS2) in addition to angiotensin converting enzyme 2 (ACE2) can facilitate SARS-CoV-2 neurotropism. Serine 107-113 transmembrane serine protease 2 Homo sapiens 124-131 34336361-2 2021 Recent studies have shown that transmembrane serine protease 2 (TMPRSS2), a protease known for similar role in previous coronavirus infections, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome (MERS), is responsible for the proteolytic cleavage of the SARS-CoV-2 spike protein, enabling host cell fusion of the virus. Serine 45-51 transmembrane serine protease 2 Homo sapiens 64-71 34209110-1 2021 Positively charged groups that mimic arginine or lysine in a natural substrate of trypsin are necessary for drugs to inhibit the trypsin-like serine protease TMPRSS2 that is involved in the viral entry and spread of coronaviruses, including SARS-CoV-2. Serine 142-148 transmembrane serine protease 2 Homo sapiens 158-165 34445373-1 2021 Human ACE2 and the serine protease TMPRSS2 of novel SARS-CoV-2 are primary entry receptors in host cells. Serine 19-25 transmembrane serine protease 2 Homo sapiens 35-42 34370633-0 2022 Molecular Modeling Targeting Transmembrane Serine Protease 2 (TMPRSS2) as an Alternative Drug Target Against Coronaviruses. Serine 43-49 transmembrane serine protease 2 Homo sapiens 62-69 34096226-1 2021 Angiotensin-converting enzyme II (ACE2) in association with type II transmembrane serine protease (TMPRSS2) is considered the main receptor of SARS-CoV-2. Serine 82-88 transmembrane serine protease 2 Homo sapiens 99-106 34181691-5 2021 SPINT2 is a member of the family of Kunitz type serine protease inhibitors and has been shown to inhibit TMPRSS2. Serine 48-54 transmembrane serine protease 2 Homo sapiens 105-112 34127969-3 2021 Serine proteases (SPs) including furin and TMPRSS2 cleave SARS-CoV-2 spike protein, facilitating viral entry. Serine 0-6 transmembrane serine protease 2 Homo sapiens 43-50 34201505-2 2021 Following the binding between S1 subunit and ACE2 receptor, different serine proteases, including TMPRSS2 and furin, trigger and participate in the fusion of the viral envelope with the host cell membrane. Serine 70-76 transmembrane serine protease 2 Homo sapiens 98-105 34514079-4 2021 Transmembrane serine-type 2 (TMPRSS2) is a SARS CoV-2 enzyme that is essential for viral fusion with the host cell. Serine 14-20 transmembrane serine protease 2 Homo sapiens 29-36 34131661-1 2021 The host cell serine protease TMPRSS2 is an attractive therapeutic target for COVID-19 drug discovery. Serine 14-20 transmembrane serine protease 2 Homo sapiens 30-37 34075338-3 2021 Similarly, a transmembrane serine protease, TMPRSS2 of the host cell plays a significant role in the proteolytic cleavage of viral "S" protein helpful for the priming of ACE2 receptors and viral entry into human cells. Serine 27-33 transmembrane serine protease 2 Homo sapiens 44-51 34693818-12 2021 The type II transmembrane serine proteases TMPRSS2 and histone acetyltransferases (HAT) are host cell proteases that are recruited by the virus to cleave ACE2 surface protein S which facilitates the viral entry. Serine 26-32 transmembrane serine protease 2 Homo sapiens 43-50 34796023-5 2021 SARS-CoV-2 enters the body with the help of the target proteins: angiotensin-converting enzyme 2 (ACE2) and associated serine protease TMPRSS2 of the nasal epithelium. Serine 119-125 transmembrane serine protease 2 Homo sapiens 135-142 35430474-2 2022 It is mediated by the binding of viral spike proteins to human cells via entry and replication processes involving human angiotensin converting enzyme-2 (hACE2), transmembrane serine protease (TMPRSS2) and cathepsin L (Cath L). Serine 176-182 transmembrane serine protease 2 Homo sapiens 193-200 35104687-1 2022 BACKGROUND: The human protein transmembrane protease serine type 2 (TMPRSS2) plays a key role in SARS-CoV-2 infection, as it is required to activate the virus" spike protein, facilitating entry into target cells. Serine 53-59 transmembrane serine protease 2 Homo sapiens 68-75 35344983-4 2022 Attractive pharmacological targets to impede viral entry include type-II transmembrane serine proteases (TTSPs), such as TMPRSS2, whose essential role in the virus lifecycle is to cleave the viral spike protein to expose the fusion peptide for cell entry5,6. Serine 87-93 transmembrane serine protease 2 Homo sapiens 121-128 35412356-1 2022 The SARS-CoV-2 coronavirus, which causes COVID-19, uses a viral surface spike protein for host cell entry and the human cell-surface transmembrane serine protease, TMPRSS2, to process the spike protein. Serine 147-153 transmembrane serine protease 2 Homo sapiens 164-171 35631327-4 2022 The catalytic activity of TMPRSS2 can be blocked by the trypsin-like serine protease inhibitor camostat, which impairs infection by SARS-CoV-2. Serine 69-75 transmembrane serine protease 2 Homo sapiens 26-33 35412405-1 2022 INTRODUCTION: The main route of transmission of SARS-CoV-2 is the upper respiratory tract via cell membranes, including angiotensin-converting enzyme 2 (ACE2) and transmembrane host-associated serine protease transmembrane serine protease 2 (TMPRSS2). Serine 193-199 transmembrane serine protease 2 Homo sapiens 242-249 35412405-1 2022 INTRODUCTION: The main route of transmission of SARS-CoV-2 is the upper respiratory tract via cell membranes, including angiotensin-converting enzyme 2 (ACE2) and transmembrane host-associated serine protease transmembrane serine protease 2 (TMPRSS2). Serine 223-229 transmembrane serine protease 2 Homo sapiens 242-249 35331159-1 2022 BACKGROUND: Host factors such as angiotensin-converting enzyme 2 (ACE2) and the transmembrane protease, serine-subtype-2 (TMPRSS2) are important factors for SARS-CoV-2 infection. Serine 104-110 transmembrane serine protease 2 Homo sapiens 122-129 35458558-3 2022 Furthermore, the expression patterns of SARS-CoV-2 entry factors, such as the receptor angiotensin-converting enzyme 2 (ACE2), as well as transmembrane protease serine subtype 2 (TMPRSS2) and cathepsin L (CTSL), cellular proteases involved in SARS-CoV-2 spike protein activation, are largely unexplored in most species. Serine 161-167 transmembrane serine protease 2 Homo sapiens 179-186 35455738-2 2022 Angiotensin-Converting Enzyme 2 (ACE2) and TransMembrane Protease Serine S1 member 2 (TMPRSS2) are enzymes that play crucial roles in SARS-CoV-2 entry into human host cells. Serine 66-72 transmembrane serine protease 2 Homo sapiens 86-93 35338216-1 2022 The cell surface serine protease Transmembrane Protease 2 (TMPRSS2) is required to cleave the spike protein of SARS-CoV-2 for viral entry into cells. Serine 17-23 transmembrane serine protease 2 Homo sapiens 59-66 35359837-6 2022 ACE2 and transmembrane serine proteinase 2 (TMPRSS2) mRNA were expressed in ALI and airway organoids at levels similar to those of native (i.e., non-cultured) human bronchial epithelial cells, whereas furin expression was more faithfully represented in ALI. Serine 23-29 transmembrane serine protease 2 Homo sapiens 44-51 35320487-2 2022 So far, it is known that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily infects the type II pneumocytes in humans, with the help of transmembrane serine protease type 2 (TMPRSS2). Serine 170-176 transmembrane serine protease 2 Homo sapiens 194-201 35345416-2 2022 Coronaviruses, as well as influenza viruses, depend on host type 2 transmembrane serine protease, TMPRSS2, for entry and propagation in the human cell. Serine 81-87 transmembrane serine protease 2 Homo sapiens 98-105 35277472-2 2022 Here, we show AKT serine/threonine kinase-dependent epigenetic control of ACE2 and TMPRSS2 expression by high-cannabidiol (CBD) cannabis extracts and their individual components. Serine 18-24 transmembrane serine protease 2 Homo sapiens 83-90 35103351-3 2022 SARS-CoV-2 infects respiratory tract epithelial cells by binding to their cell membrane ACE2, followed by priming for cell entry by the host cell membrane serine protease TMPRSS2. Serine 155-161 transmembrane serine protease 2 Homo sapiens 171-178 34862332-2 2022 Angiotensin-converting enzyme-2 (ACE2) is the receptor responsible for coronavirus binding, while subsequent cell entry relies on priming by the serine protease TMPRSS2 (transmembrane protease, serine 2). Serine 145-151 transmembrane serine protease 2 Homo sapiens 161-168 34862332-2 2022 Angiotensin-converting enzyme-2 (ACE2) is the receptor responsible for coronavirus binding, while subsequent cell entry relies on priming by the serine protease TMPRSS2 (transmembrane protease, serine 2). Serine 194-200 transmembrane serine protease 2 Homo sapiens 161-168 35193695-1 2022 OBJECTIVE: To determine the effect of polymorphisms and mutations in angiotensin-converting enzyme 2 (ACE2) and Type 2 transmembrane serine proteases (TMPRSS2) genes on susceptibility to corona virus disease 2019 (COVID-19) and patient prognosis. Serine 133-139 transmembrane serine protease 2 Homo sapiens 151-158 35063125-6 2022 Moreover, entry of SARS-CoV-2 into BCECs could be reduced by anti-spike-, anti-angiotensin-converting enzyme 2 (ACE2)-, and anti-neuropilin-1 (NRP1)-specific antibodies or the transmembrane protease serine subtype 2 (TMPRSS2) inhibitor nafamostat. Serine 199-205 transmembrane serine protease 2 Homo sapiens 217-224 35170548-1 2022 Transmembrane serine proteinase 2 (TMPRSS2), which is an essential serine protease for priming spike protein of SARS-CoV-2, was found in low expression in many cancer tissue including lung cancer. Serine 14-20 transmembrane serine protease 2 Homo sapiens 35-42 35226423-1 2022 BACKGROUND: Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine subtype 2 (TMPRSS2) are key proteins mediating viral entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Serine 78-84 transmembrane serine protease 2 Homo sapiens 96-103 35160229-0 2022 Angiotensin-Converting Enzyme 2 (ACE2), Transmembrane Peptidase Serine 2 (TMPRSS2), and Furin Expression Increases in the Lungs of Patients with Idiopathic Pulmonary Fibrosis (IPF) and Lymphangioleiomyomatosis (LAM): Implications for SARS-CoV-2 (COVID-19) Infections. Serine 64-70 transmembrane serine protease 2 Homo sapiens 74-81 35154056-6 2022 By contrast, an important SARS-CoV-2 infection-associated factor, type II transmembrane serine protease (TMPRSS2), was poorly expressed in placenta. Serine 88-94 transmembrane serine protease 2 Homo sapiens 105-112 35128036-2 2022 Because the androgen-responsive serine protease TMPRSS2 is involved in cleaving the SARS-CoV-2 spike protein allowing the virus to enter the cell, therefore, direct TMPRSS2 inhibition will inhibit virus activation and disease progression which make it an important target for drug discovery. Serine 32-38 transmembrane serine protease 2 Homo sapiens 48-55 35128036-2 2022 Because the androgen-responsive serine protease TMPRSS2 is involved in cleaving the SARS-CoV-2 spike protein allowing the virus to enter the cell, therefore, direct TMPRSS2 inhibition will inhibit virus activation and disease progression which make it an important target for drug discovery. Serine 32-38 transmembrane serine protease 2 Homo sapiens 165-172 35039793-7 2022 The receptor ACE2 mediates the entry of SARS-CoV-2 into the host cells, whereas the serine protease TMPRSS2 primes the viral S protein. Serine 84-90 transmembrane serine protease 2 Homo sapiens 100-107