PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22865246-4 2012 In the brain, the concentration of D-serine stored in cells is defined by the activity of two enzymes: serine racemase (responsible for both the synthesis and degradation) and D-amino acid oxidase (which catalyzes D-serine degradation). Serine 37-43 serine racemase Homo sapiens 103-118 22890612-5 2012 In sporadic ALS cases, elevated D-serine may arise from induction of serine racemase, its synthetic enzyme, caused by cell stress and inflammatory processes thought to contribute to disease progression. Serine 34-40 serine racemase Homo sapiens 69-84 22311068-1 2012 D-Serine is known to act as an endogenous co-agonist of the N-methyl-D-aspartate receptor in the mammalian brain and is endogenously synthesized from L-serine by a pyridoxal 5"-phosphate-dependent enzyme, serine racemase. Serine 150-158 serine racemase Homo sapiens 205-220 22507034-2 2012 As apoptosis is associated with several diseases and conditions that generally occur with age, we investigated the modulation of SR/d-serine pathway during neuronal apoptosis and its impact on survival. Serine 134-140 serine racemase Homo sapiens 129-131 22507034-3 2012 We found that in cerebellar granule neurons (CGNs), undergoing apoptosis SR/d-serine pathway is crucially regulated. Serine 78-84 serine racemase Homo sapiens 73-75 22354542-1 2012 Serine racemase (SR) is the only identified enzyme in mammals responsible for isomerization of L-serine to D-serine, a coagonist at N-methyl-D-aspartate (NMDA) receptors in the forebrain. Serine 95-103 serine racemase Homo sapiens 0-15 22354542-1 2012 Serine racemase (SR) is the only identified enzyme in mammals responsible for isomerization of L-serine to D-serine, a coagonist at N-methyl-D-aspartate (NMDA) receptors in the forebrain. Serine 95-103 serine racemase Homo sapiens 17-19 22037294-7 2012 This method was used to determine the concentration-dependent increases in D-Ser and associated EC50 values produced by L-Ser and the concentration-dependent decreases in d-Ser and associated IC50 values produced by glycine, a competitive inhibitor of serine racemase (SR). Serine 120-125 serine racemase Homo sapiens 252-267 21956576-1 2012 Serine racemase is a glial and neuronal enzyme that reversibly converts L-serine to D-serine, an endogenous co-agonist of N-methyl-D-aspartate receptor type glutamate receptors (NMDARs). Serine 72-80 serine racemase Homo sapiens 0-15 22151352-5 2011 RESULTS: Michaelis-Menten kinetic analysis indicated a KM value of 14 mM and Vmax value of 3.66 mumol mg-1 hr-1 when L-serine was used as a substrate for purified SR. Serine 117-125 serine racemase Homo sapiens 163-165 21224019-5 2011 I propose a role for SR in a novel form of astrocyte-neuron communication-the "serine shuttle", whereby astrocytes synthesize and export l-serine required for the synthesis of d-serine by the predominantly neuronal SR. Serine 79-85 serine racemase Homo sapiens 21-23 21224019-5 2011 I propose a role for SR in a novel form of astrocyte-neuron communication-the "serine shuttle", whereby astrocytes synthesize and export l-serine required for the synthesis of d-serine by the predominantly neuronal SR. Serine 79-85 serine racemase Homo sapiens 215-217 21224019-5 2011 I propose a role for SR in a novel form of astrocyte-neuron communication-the "serine shuttle", whereby astrocytes synthesize and export l-serine required for the synthesis of d-serine by the predominantly neuronal SR. Serine 137-145 serine racemase Homo sapiens 21-23 27466949-1 2011 Serine racemase (SR) is a PLP-dependent enzyme catalyzing the racemization of L-Ser into D-Ser, which is now recognized as an endogenous co-agonist at the NMDA receptor complex. Serine 78-83 serine racemase Homo sapiens 0-15 27466949-1 2011 Serine racemase (SR) is a PLP-dependent enzyme catalyzing the racemization of L-Ser into D-Ser, which is now recognized as an endogenous co-agonist at the NMDA receptor complex. Serine 78-83 serine racemase Homo sapiens 17-19 21655447-4 2011 Eph receptors regulate this response by inducing the dephosphorylation of PKCalpha and activation of serine racemase to convert L-serine to D-serine. Serine 128-136 serine racemase Homo sapiens 101-116 21886585-3 2011 Serine racemase converts l-serine to d-serine, which is an endogenous co-agonist for NMDA receptors. Serine 25-33 serine racemase Homo sapiens 0-15 20300853-4 2010 On basis of the fasting state, ketone bodies and lactate in plasma, urine and CSF, we speculate that reduced serine levels were due to its use as gluconeogenic substrate, conversion to pyruvate by brain serine racemase or decreased L-serine production because of a lack of glucose. Serine 109-115 serine racemase Homo sapiens 203-218 21106840-7 2010 Eph receptors mediate this response through interactions with PICK1 (protein interacting with C-kinase) and by dephosphorylating protein kinase C alpha to activate the conversion of l-serine to d-serine by serine racemase. Serine 182-190 serine racemase Homo sapiens 206-221 20195697-2 2010 D-Serine is synthesized in glial cells and neurons by the pyridoxal-5" phosphate-dependent enzyme serine racemase, and it is released upon activation of glutamate receptors. Serine 2-8 serine racemase Homo sapiens 98-113 20091774-2 2010 It is synthesized from L-serine by serine racemase (SRR), but many aspects of its metabolism remain unclear, especially in the forebrain, which lacks active D-amino acid oxidase (DAO), the major D-serine degradative enzyme. Serine 23-31 serine racemase Homo sapiens 35-50 20091774-2 2010 It is synthesized from L-serine by serine racemase (SRR), but many aspects of its metabolism remain unclear, especially in the forebrain, which lacks active D-amino acid oxidase (DAO), the major D-serine degradative enzyme. Serine 23-31 serine racemase Homo sapiens 52-55 20091774-3 2010 Candidate mechanisms include SRR operating in alpha,beta-eliminase mode (converting D-serine to pyruvate) and regulation by serine transport, in which the alanine-serine-cysteine transporter ASCT2 is implicated. Serine 86-92 serine racemase Homo sapiens 29-32 20091774-6 2010 Incubation with serine enantiomers decreased [(3)H]D-serine uptake and ASCT2 mRNA and increased SRR immunoreactivity but did not alter DAO immunoreactivity, and DAO activity remained undetectable. Serine 16-22 serine racemase Homo sapiens 96-99 20091774-7 2010 SRR overexpression increased D-serine and pyruvate and decreased [(3)H]D-serine uptake and ASCT2 mRNA but did not affect DAO. Serine 31-37 serine racemase Homo sapiens 0-3 21417027-3 2009 It is synthesized from L-serine via racemization of serine racemase, which is regulated by many factors. Serine 23-31 serine racemase Homo sapiens 52-67 19640845-2 2009 Mammalian pyridoxal 5"-phosphate-dependent serine racemase, which is localized in the mammalian brain, catalyzes the racemization of L-serine to yield D-serine and vice versa. Serine 133-141 serine racemase Homo sapiens 43-58 19193859-3 2009 We show that serine racemase (SR), which generates D-serine from L-serine, is physiologically inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2) presence in membranes where SR is localized. Serine 65-73 serine racemase Homo sapiens 13-28 19193859-3 2009 We show that serine racemase (SR), which generates D-serine from L-serine, is physiologically inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2) presence in membranes where SR is localized. Serine 65-73 serine racemase Homo sapiens 30-32 19193859-3 2009 We show that serine racemase (SR), which generates D-serine from L-serine, is physiologically inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2) presence in membranes where SR is localized. Serine 65-73 serine racemase Homo sapiens 182-184 18692067-1 2008 Binding of the transcription factor Ets-1 to DNA is allosterically regulated by a serine-rich region (SRR) that modulates the dynamic character of the adjacent structured DNA-binding ETS domain and its flanking autoinhibitory elements. Serine 82-88 serine racemase Homo sapiens 102-105 18564180-7 2008 However, recent data indicate that serine racemase, the D-serine biosynthetic enzyme, is widely expressed in neurons of the brain, suggesting that D-serine also has a neuronal origin. Serine 58-64 serine racemase Homo sapiens 35-50 17663143-5 2007 D-Serine is synthesized by serine racemase (SR) from L-serine. Serine 53-61 serine racemase Homo sapiens 27-42 17663143-5 2007 D-Serine is synthesized by serine racemase (SR) from L-serine. Serine 53-61 serine racemase Homo sapiens 44-46 17067558-1 2007 BACKGROUND: Serine racemase (SRR) is a brain-enriched enzyme that converts L-serine to D-serine, which acts as an endogenous ligand of N-methyl D-aspartate (NMDA) receptors. Serine 77-83 serine racemase Homo sapiens 12-27 17067558-1 2007 BACKGROUND: Serine racemase (SRR) is a brain-enriched enzyme that converts L-serine to D-serine, which acts as an endogenous ligand of N-methyl D-aspartate (NMDA) receptors. Serine 77-83 serine racemase Homo sapiens 29-32 17067558-1 2007 BACKGROUND: Serine racemase (SRR) is a brain-enriched enzyme that converts L-serine to D-serine, which acts as an endogenous ligand of N-methyl D-aspartate (NMDA) receptors. Serine 89-95 serine racemase Homo sapiens 12-27 17067558-1 2007 BACKGROUND: Serine racemase (SRR) is a brain-enriched enzyme that converts L-serine to D-serine, which acts as an endogenous ligand of N-methyl D-aspartate (NMDA) receptors. Serine 89-95 serine racemase Homo sapiens 29-32 16182447-1 2006 In the human glioblastoma cell line U87, the activity of serine racemase (SR), catalyzing the isomerisation of serine, was inversely regulated by D-serine and nitric oxide (NO), a neuromodulator and a neurotransmitter, respectively. Serine 57-63 serine racemase Homo sapiens 74-76 15953485-2 2005 In this study, we examined the genetic roles of serine racemase (SRR), an enzyme catalyzing the formation of D-serine from L-serine, and D-amino-acid oxidase (DAO) in the susceptibility to schizophrenia and the regulation of serum D-serine levels. Serine 123-131 serine racemase Homo sapiens 48-63 15953485-2 2005 In this study, we examined the genetic roles of serine racemase (SRR), an enzyme catalyzing the formation of D-serine from L-serine, and D-amino-acid oxidase (DAO) in the susceptibility to schizophrenia and the regulation of serum D-serine levels. Serine 123-131 serine racemase Homo sapiens 65-68 15681805-1 2004 Serine racemase (SRace) is an enzyme that catalyzes the conversion of L-serine to pyruvate or D-serine, an endogenous agonist for NMDA receptors. Serine 70-78 serine racemase Homo sapiens 0-15 15681805-1 2004 Serine racemase (SRace) is an enzyme that catalyzes the conversion of L-serine to pyruvate or D-serine, an endogenous agonist for NMDA receptors. Serine 70-78 serine racemase Homo sapiens 17-22 15252817-4 2004 A new enzyme, serine racemase has been localized to glial cells and converts L-serine to D-serine. Serine 77-85 serine racemase Homo sapiens 14-29 16543946-2 2004 D-serine is synthesized from L-serine by serine racemase in astrocytic glia that ensheath synapses, especially in regions of the brain that are enriched in NMDA-glutamate receptors. Serine 29-37 serine racemase Homo sapiens 41-56 15285800-6 2004 Microglial cell lysates were examined for the levels of mRNA and protein for serine racemase, the enzyme that forms D-serine from L-serine. Serine 130-138 serine racemase Homo sapiens 77-92 14751437-7 2004 The present study suggests that the reduced activity of serine racemase, an enzyme catalyzing the formation of D-serine from L-serine may play a role in the pathophysiology of AD. Serine 113-119 serine racemase Homo sapiens 56-71 12796220-9 2003 In addition, the percentage of D-serine in the total serine in the schizophrenic patients was significantly (z = -4.78, P<.001) lower than that of controls, suggesting that the activity of serine racemase, an enzyme catalyzing the formation of D-serine from L-serine, may have been reduced in the schizophrenic patients. Serine 33-39 serine racemase Homo sapiens 192-207 12796220-9 2003 In addition, the percentage of D-serine in the total serine in the schizophrenic patients was significantly (z = -4.78, P<.001) lower than that of controls, suggesting that the activity of serine racemase, an enzyme catalyzing the formation of D-serine from L-serine, may have been reduced in the schizophrenic patients. Serine 261-269 serine racemase Homo sapiens 192-207 12021263-1 2002 Serine racemase (SR) is a brain enzyme present in glial cells, where it isomerizes L-serine into D-serine that, in turn, diffuses and coactivates the N-methyl-D-aspartate receptor through the binding to the so-called "glycine site." Serine 83-91 serine racemase Homo sapiens 0-15 12021263-1 2002 Serine racemase (SR) is a brain enzyme present in glial cells, where it isomerizes L-serine into D-serine that, in turn, diffuses and coactivates the N-methyl-D-aspartate receptor through the binding to the so-called "glycine site." Serine 83-91 serine racemase Homo sapiens 17-19 12021263-2 2002 We have developed a method for the slow expression of SR in a eukaryotic vector that permits the correct insertion of the prosthetic group into the active site, rendering functional SR with a K(m) toward L-serine of 4.8 mm. Serine 204-212 serine racemase Homo sapiens 54-56 12021263-2 2002 We have developed a method for the slow expression of SR in a eukaryotic vector that permits the correct insertion of the prosthetic group into the active site, rendering functional SR with a K(m) toward L-serine of 4.8 mm. Serine 204-212 serine racemase Homo sapiens 182-184 12021263-9 2002 Additionally, 16 serine analogues were tested as a putative SR substrate or inhibitors. Serine 17-23 serine racemase Homo sapiens 60-62 11309496-5 2001 We establish stable cell lines expressing serine racemase and show that serine racemase can also be converted into a powerful eliminase in cultured cells, while the racemization of l-serine is inhibited. Serine 181-189 serine racemase Homo sapiens 42-57 11058466-8 2000 D-Serine is formed by serine racemase, which directly converts L-serine to D-serine. Serine 63-71 serine racemase Homo sapiens 22-37 11054547-3 2000 We now report cloning and expression of human serine racemase, an enzyme that catalyses the synthesis of D-serine from L-serine. Serine 119-127 serine racemase Homo sapiens 46-61 10905615-5 2000 D-serine is also formed by serine racemase, a recently cloned enzyme that converts L-serine to D-serine. Serine 83-91 serine racemase Homo sapiens 27-42 10890022-7 2000 Recently, the conversion of L-serine to its D-form by serine racemase has been suggested by in vivo and in vitro experiments. Serine 30-36 serine racemase Homo sapiens 54-69 10557334-4 1999 We now report cloning and expression of serine racemase, an enzyme catalyzing the formation of D-serine from L-serine. Serine 109-117 serine racemase Homo sapiens 40-55 35195906-3 2022 In physiological conditions, D-serine is produced and released by neurons from the enzymatic conversion of L-serine by serine racemase (SRR). Serine 31-37 serine racemase Homo sapiens 119-134 35195906-3 2022 In physiological conditions, D-serine is produced and released by neurons from the enzymatic conversion of L-serine by serine racemase (SRR). Serine 109-115 serine racemase Homo sapiens 119-134 35482677-2 2022 In the brain, d-serine is synthesized from its l-isomer by serine racemase and is metabolized by the D-amino acid oxidase (DAO, DAAO). Serine 16-22 serine racemase Homo sapiens 59-74 35563349-1 2022 Human serine racemase (hSR) is a pyridoxal-5"-phosphate (PLP)-dependent dimer that catalyzes the formation of D-serine from L-serine, as well as the dehydration of both L- and D-serine to pyruvate and ammonia. Serine 112-118 serine racemase Homo sapiens 6-21 35563349-1 2022 Human serine racemase (hSR) is a pyridoxal-5"-phosphate (PLP)-dependent dimer that catalyzes the formation of D-serine from L-serine, as well as the dehydration of both L- and D-serine to pyruvate and ammonia. Serine 126-132 serine racemase Homo sapiens 6-21 35563349-1 2022 Human serine racemase (hSR) is a pyridoxal-5"-phosphate (PLP)-dependent dimer that catalyzes the formation of D-serine from L-serine, as well as the dehydration of both L- and D-serine to pyruvate and ammonia. Serine 178-184 serine racemase Homo sapiens 6-21 35410329-1 2022 Human serine racemase (hSR) catalyses racemisation of L-serine to D-serine, the latter of which is a co-agonist of the NMDA subtype of glutamate receptors that are important in synaptic plasticity, learning and memory. Serine 56-62 serine racemase Homo sapiens 6-21 35410329-1 2022 Human serine racemase (hSR) catalyses racemisation of L-serine to D-serine, the latter of which is a co-agonist of the NMDA subtype of glutamate receptors that are important in synaptic plasticity, learning and memory. Serine 68-74 serine racemase Homo sapiens 6-21 35346007-2 2022 D-Serine is implicated in the pathophysiological progression of AD and it is produced by the enzyme serine racemase (SR) in the brain and functions as an endogenous co-agonist at the glycine-binding site of N-methyl-D-aspartate receptor (NMDAR). Serine 2-8 serine racemase Homo sapiens 100-115 34041270-9 2021 Taken together, these findings indicate that D-serine levels can be also modulated by post-translational modifications of hDAAO as also known for the D-serine synthetic enzyme serine racemase. Serine 47-53 serine racemase Homo sapiens 176-191 34041270-9 2021 Taken together, these findings indicate that D-serine levels can be also modulated by post-translational modifications of hDAAO as also known for the D-serine synthetic enzyme serine racemase. Serine 152-158 serine racemase Homo sapiens 176-191 33592203-3 2021 Serine racemase (SR) is a neuronal enzyme that produces D-serine, a co-agonist required for full NMDAR activation. Serine 58-64 serine racemase Homo sapiens 0-15 32971286-1 2021 Murine serine racemase (SR), the enzyme responsible for the biosynthesis of the neuromodulator d-serine, was reported to form a complex with glyceraldehyde 3-phosphate dehydrogenase (GAPDH), resulting in SR inhibition. Serine 7-13 serine racemase Homo sapiens 24-26 32971286-1 2021 Murine serine racemase (SR), the enzyme responsible for the biosynthesis of the neuromodulator d-serine, was reported to form a complex with glyceraldehyde 3-phosphate dehydrogenase (GAPDH), resulting in SR inhibition. Serine 7-13 serine racemase Homo sapiens 204-206 32594192-2 2020 Moreover, L-serine is the precursor of two relevant coagonists of NMDA receptors: glycine (through the enzyme serine hydroxymethyltransferase), which preferentially acts on extrasynaptic receptors and D-serine (through the enzyme serine racemase), dominant at synaptic receptors. Serine 12-18 serine racemase Homo sapiens 230-245 32170206-1 2020 Serine racemase (SR) converts the free form of L-serine into D-serine (DS) in the mammalian brain. Serine 49-55 serine racemase Homo sapiens 0-15 32170206-1 2020 Serine racemase (SR) converts the free form of L-serine into D-serine (DS) in the mammalian brain. Serine 63-69 serine racemase Homo sapiens 0-15 32039887-1 2020 Serine racemase (SR) is a pyridoxal 5"-phosphate (PLP)-containing enzyme that converts L-serine to D-serine, an endogenous co-agonist for the N-methyl-D-aspartate receptor (NMDAR) subtype of glutamate ion channels. Serine 89-95 serine racemase Homo sapiens 0-15 32039887-1 2020 Serine racemase (SR) is a pyridoxal 5"-phosphate (PLP)-containing enzyme that converts L-serine to D-serine, an endogenous co-agonist for the N-methyl-D-aspartate receptor (NMDAR) subtype of glutamate ion channels. Serine 101-107 serine racemase Homo sapiens 0-15 32694681-0 2020 Serine racemase enhances growth of colorectal cancer by producing pyruvate from serine. Serine 80-86 serine racemase Homo sapiens 0-15 32694681-1 2020 Serine racemase (SRR) catalyses not only the racemization but also the dehydration of L-serine and D-serine, resulting in the formation of pyruvate and ammonia. Serine 88-94 serine racemase Homo sapiens 0-15 32694681-1 2020 Serine racemase (SRR) catalyses not only the racemization but also the dehydration of L-serine and D-serine, resulting in the formation of pyruvate and ammonia. Serine 88-94 serine racemase Homo sapiens 17-20 32694681-1 2020 Serine racemase (SRR) catalyses not only the racemization but also the dehydration of L-serine and D-serine, resulting in the formation of pyruvate and ammonia. Serine 101-107 serine racemase Homo sapiens 0-15 32694681-1 2020 Serine racemase (SRR) catalyses not only the racemization but also the dehydration of L-serine and D-serine, resulting in the formation of pyruvate and ammonia. Serine 101-107 serine racemase Homo sapiens 17-20 32694681-5 2020 SRR-mediated dehydration of serine contributes to the pyruvate pool in colon-cancer cells, enhances proliferation, maintains mitochondrial mass and increases basal reactive oxygen species production, which has anti-apoptotic effects. Serine 28-34 serine racemase Homo sapiens 0-3 30918891-1 2019 Serine racemase (SR) is the first racemase enzyme to be identified in human biology and converts L-serine to D-serine, an important neuronal signaling molecule that serves as a co-agonist of the NMDA (N-methyl-D-aspartate) receptor. Serine 97-105 serine racemase Homo sapiens 0-15 30918891-1 2019 Serine racemase (SR) is the first racemase enzyme to be identified in human biology and converts L-serine to D-serine, an important neuronal signaling molecule that serves as a co-agonist of the NMDA (N-methyl-D-aspartate) receptor. Serine 97-105 serine racemase Homo sapiens 17-19 30687716-1 2018 Human serine racemase is a pyridoxal 5"-phosphate (PLP)-dependent dimeric enzyme that catalyzes the reversible racemization of L-serine and D-serine and their dehydration to pyruvate and ammonia. Serine 127-135 serine racemase Homo sapiens 6-21 30546256-6 2018 A special enzyme, serine racemase (SR), is required for the conversion of L-serine into D-serine, and alterations in SR activities lead to a variety of physiological and pathological conditions ranging from synaptic plasticity to ischemia, MI, and stroke. Serine 74-82 serine racemase Homo sapiens 18-33 30546256-6 2018 A special enzyme, serine racemase (SR), is required for the conversion of L-serine into D-serine, and alterations in SR activities lead to a variety of physiological and pathological conditions ranging from synaptic plasticity to ischemia, MI, and stroke. Serine 74-82 serine racemase Homo sapiens 35-37 30546256-6 2018 A special enzyme, serine racemase (SR), is required for the conversion of L-serine into D-serine, and alterations in SR activities lead to a variety of physiological and pathological conditions ranging from synaptic plasticity to ischemia, MI, and stroke. Serine 74-82 serine racemase Homo sapiens 117-119 29976992-1 2018 The spatio-temporal regulation of genes involved in the synthesis and degradation of D-serine and D-aspartate such as serine racemase (SR), D-amino acid oxidase (DAO), G72 and D-aspartate oxidase (DDO), play pivotal roles in determining the correct levels of these D-amino acids in the human brain. Serine 87-93 serine racemase Homo sapiens 118-133 29976992-1 2018 The spatio-temporal regulation of genes involved in the synthesis and degradation of D-serine and D-aspartate such as serine racemase (SR), D-amino acid oxidase (DAO), G72 and D-aspartate oxidase (DDO), play pivotal roles in determining the correct levels of these D-amino acids in the human brain. Serine 87-93 serine racemase Homo sapiens 135-137 29899358-1 2018 Serine racemase (SR) catalyses two reactions: the reversible racemisation of L-serine and the irreversible dehydration of L- and D-serine to pyruvate and ammonia. Serine 77-85 serine racemase Homo sapiens 0-15 29363864-2 2018 Serine racemase (SRR) is responsible for transforming L-serine to D-serine. Serine 54-62 serine racemase Homo sapiens 0-15 29363864-2 2018 Serine racemase (SRR) is responsible for transforming L-serine to D-serine. Serine 54-62 serine racemase Homo sapiens 17-20 29025687-3 2018 N-methyl-D-aspartate receptor activation requires the binding of a coagonist, D-serine, which is synthesized from L-serine by the neuronal enzyme serine racemase (SR). Serine 114-122 serine racemase Homo sapiens 146-161 29413526-6 2018 Serine racemase and other components of the serine shuttle are therefore promising targets for neuroprotective drugs. Serine 44-50 serine racemase Homo sapiens 0-15 26941605-1 2016 D-serine is an endogenous coagonist at the glycine site of synaptic NMDA receptors (NMDARs), synthesized by serine racemase (SR) through conversion of L-serine. Serine 151-159 serine racemase Homo sapiens 108-123 26941605-1 2016 D-serine is an endogenous coagonist at the glycine site of synaptic NMDA receptors (NMDARs), synthesized by serine racemase (SR) through conversion of L-serine. Serine 151-159 serine racemase Homo sapiens 125-127 26553873-3 2015 D-Serine is synthesized by the enzyme serine racemase (SR), which directly converts L-serine to D-serine. Serine 84-92 serine racemase Homo sapiens 38-53 26553873-3 2015 D-Serine is synthesized by the enzyme serine racemase (SR), which directly converts L-serine to D-serine. Serine 84-92 serine racemase Homo sapiens 55-57 25493718-1 2015 Serine racemase (SerR) is a pyridoxal-5"-phosphate (PLP)-dependent enzyme catalyzing the racemization of l-Ser to d-Ser. Serine 105-110 serine racemase Homo sapiens 0-15 25493718-1 2015 Serine racemase (SerR) is a pyridoxal-5"-phosphate (PLP)-dependent enzyme catalyzing the racemization of l-Ser to d-Ser. Serine 105-110 serine racemase Homo sapiens 17-21 25493718-8 2015 In addition to a deeper understanding of the racemization mechanism in SerR, based on our simulations we propose specific mutations, which might shift the SerR equilibrium in favor of either l-Ser or d-Ser. Serine 191-196 serine racemase Homo sapiens 71-75 25493718-8 2015 In addition to a deeper understanding of the racemization mechanism in SerR, based on our simulations we propose specific mutations, which might shift the SerR equilibrium in favor of either l-Ser or d-Ser. Serine 191-196 serine racemase Homo sapiens 155-159 25462239-2 2015 Production of d-serine, an NMDA receptor co-agonist, from l-serine is catalyzed in vivo by the pyridoxal-5"-phosphate (PLP)-dependent enzyme serine racemase. Serine 58-66 serine racemase Homo sapiens 141-156 25336657-2 2014 d-Serine is synthesized from l-serine by serine racemase (SR), a brain-enriched enzyme. Serine 29-37 serine racemase Homo sapiens 41-56 25336657-2 2014 d-Serine is synthesized from l-serine by serine racemase (SR), a brain-enriched enzyme. Serine 29-37 serine racemase Homo sapiens 58-60 25164819-2 2014 Serine racemase (SR) is the enzyme that converts L-serine to D-serine. Serine 49-57 serine racemase Homo sapiens 0-15 25164819-2 2014 Serine racemase (SR) is the enzyme that converts L-serine to D-serine. Serine 49-57 serine racemase Homo sapiens 17-19 24436034-1 2014 D-Serine, a co-agonist at the NMDA receptor (NMDAR), is synthesized from L-serine by the enzyme serine racemase (SR), which is heavily expressed in the forebrain. Serine 73-81 serine racemase Homo sapiens 96-111 24436034-1 2014 D-Serine, a co-agonist at the NMDA receptor (NMDAR), is synthesized from L-serine by the enzyme serine racemase (SR), which is heavily expressed in the forebrain. Serine 73-81 serine racemase Homo sapiens 113-115 24256252-7 2013 These findings support a model whereby astrocyte-derived L-serine shuttles to neurons to fuel the synthesis of D-serine by serine racemase. Serine 57-65 serine racemase Homo sapiens 123-138 23992455-3 2013 In the human brain, d-serine is synthesized from l-serine by the dimeric pyridoxal 5"-phosphate-dependent enzyme serine racemase, which also degrades l- and d-serine to pyruvate and ammonia. Serine 49-57 serine racemase Homo sapiens 113-128 23747871-1 2013 Serine racemase is the pyridoxal 5"-phosphate-dependent enzyme that catalyzes L-serine racemisation to D-serine, and L- and D-serine beta-elimination in mammalian brain. Serine 78-86 serine racemase Homo sapiens 0-15