PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26998348-0 2015 The MDM2 small-molecule inhibitor RG7388 leads to potent tumor inhibition in p53 wild-type neuroblastoma. RG7388 34-40 transformation related protein 53, pseudogene Mus musculus 77-80 31311404-0 2019 MDM2 inhibitor RG7388 potently inhibits tumors by activating p53 pathway in nasopharyngeal carcinoma. RG7388 15-21 transformation related protein 53, pseudogene Mus musculus 61-64 27353420-2 2016 In this study, we deliver the rationale and molecular basis for the combination of idasanutlin and venetoclax for treatment of p53 wild-type AML. RG7388 83-94 transformation related protein 53, pseudogene Mus musculus 127-130 27353420-6 2016 RESULTS: Combination treatment with venetoclax and idasanutlin results in synergistic anti-tumor activity compared with the respective single-agent treatments in vitro, in p53 wild-type AML cell lines, and leads to strongly superior efficacy in vivo, in subcutaneous and orthotopic AML models. RG7388 51-62 transformation related protein 53, pseudogene Mus musculus 172-175 27353420-9 2016 As expected, gene expression studies using RNA sequencing showed significant alterations to pathways associated with p53 signaling and cell cycle arrest (CCND1 pathway) in response to idasanutlin treatment. RG7388 184-195 transformation related protein 53, pseudogene Mus musculus 117-120