PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32741700-6 2022 Currently, multiple p53-MDM2/MDM4 antagonists are undergoing clinical trials, the most advanced being idasanutlin which is currently undergoing testing in a phase III clinical trial in patients with relapsed or refractory acute myeloid leukemia. RG7388 102-113 MDM4 regulator of p53 Homo sapiens 29-33 35420431-3 2022 In three MDM4-overexpressing cancer cell lines harboring wild-type p53, 31 shows improved cell growth inhibition activities compared to RG7388, an MDM2-selective inhibitor in late-stage clinical trials. RG7388 136-142 MDM4 regulator of p53 Homo sapiens 9-13