PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31004033-7 2019 RG7388 induced a pro-apoptotic gene expression signature with upregulation of p53-target genes involved in the intrinsic (PUMA, BAX) and extrinsic (TNFRSF10B, FAS) pathways of apoptosis, as well as MDM2 Only a slight induction of CDKN1A was observed and upregulation of pro-apoptotic genes dominated, indicating that CLL cells are primed for p53-dependent apoptosis. RG7388 0-6 BCL2 binding component 3 Homo sapiens 122-126