PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33051060-0 2020 Combination of metformin and RG7388 enhances inhibition of growth and induction of apoptosis of ovarian cancer cells through the PI3K/AKT/mTOR pathway. RG7388 29-35 mechanistic target of rapamycin kinase Homo sapiens 138-142 33051060-10 2020 Additionally, in vitro and in vivo results showed that MET and/or RG7388 inhibited the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway and their combination had a stronger effect. RG7388 66-72 mechanistic target of rapamycin kinase Homo sapiens 124-153 33051060-10 2020 Additionally, in vitro and in vivo results showed that MET and/or RG7388 inhibited the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway and their combination had a stronger effect. RG7388 66-72 mechanistic target of rapamycin kinase Homo sapiens 155-159 33051060-11 2020 Our findings suggest that the combination of MET and RG7388 enhances growth inhibition and apoptosis induction of ovarian cancer cells through the PI3K/AKT/mTOR pathway and accumulation of intracellular ROS. RG7388 53-59 mechanistic target of rapamycin kinase Homo sapiens 156-160