PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33850004-11 2021 This study demonstrates that idasanutlin can overcome resistance to the BCL-2 inhibitor venetoclax in preclinical neuroblastoma model systems, which supports clinical development of a treatment strategy combining the two therapies. RG7388 29-40 BCL2 apoptosis regulator Homo sapiens 72-77 29768700-1 2018 Venetoclax (ABT-199) and idasanutlin (RG7388) are efficient anticancer drugs targeting two essential apoptosis markers, Bcl-2 and MDM2, respectively. RG7388 25-36 BCL2 apoptosis regulator Homo sapiens 120-125 32827690-12 2020 This study further opens new avenues for the use of RG-7388 in treating osteosarcomas that often becomes resistant to chemotherapy due to Bcl-2 overexpression. RG7388 52-59 BCL2 apoptosis regulator Homo sapiens 138-143