PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14604668-3 2003 It was concluded that replacing the natural C4 of fumagillin with a benzyl oxime at C4 resulted in moderate loss of activity toward binding to MetAP2. fumagillin 50-60 methionyl aminopeptidase 2 Homo sapiens 143-149 17450475-9 2007 Fumagillin, a MetAP2 specific inhibitor, significantly inhibited cell proliferation in dose dependent manner and the degree of growth inhibition was dependent on the amount of cellular enzyme. fumagillin 0-10 methionyl aminopeptidase 2 Homo sapiens 14-20 16267007-8 2005 In addition, we show that Nf1-deficient astrocytes overexpress MetAP2 in vitro and in vivo, and that treatment with the MetAP2 inhibitor fumagillin significantly reduces Nf1-/- astrocyte proliferation in vitro. fumagillin 137-147 methionyl aminopeptidase 2 Homo sapiens 63-69 16267007-8 2005 In addition, we show that Nf1-deficient astrocytes overexpress MetAP2 in vitro and in vivo, and that treatment with the MetAP2 inhibitor fumagillin significantly reduces Nf1-/- astrocyte proliferation in vitro. fumagillin 137-147 methionyl aminopeptidase 2 Homo sapiens 120-126 23480755-2 2012 Fumagillin, a specific MetAP2 inhibitor, suppresses CCA cell proliferation. fumagillin 0-10 methionyl aminopeptidase 2 Homo sapiens 23-29 23480758-2 2012 We reported previously suppressive effects of fumagillin, a MetAP2 inhibitor, on growth of CCA cell lines. fumagillin 46-56 methionyl aminopeptidase 2 Homo sapiens 60-66 22229417-5 2012 Several fumagillin analogs, like CKD-732, TNP-470 and PPI-2458, were found to be potent selective inhibitors of MetAP-2 (proteolytic activity) and endothelial cell proliferation. fumagillin 8-18 methionyl aminopeptidase 2 Homo sapiens 112-119 15962312-4 2005 The cellular levels of MetAP-2 enzyme were measured after MetAP-2 siRNA treatment and found to decrease over time from 4 to 96 h, while rapid and complete depletion of MetAP-2 enzyme activity was observed after 4 h treatment with two pharmacological inhibitors of MetAP-2, PPI-2458 and fumagillin. fumagillin 286-296 methionyl aminopeptidase 2 Homo sapiens 23-30 15962312-5 2005 When HUVEC and A549 cells were treated simultaneously with MetAP-2 siRNA and PPI-2458, or fumagillin, which irreversibly inhibit MetAP-2 enzyme activity, no additive effect on maximum growth inhibition was observed. fumagillin 90-100 methionyl aminopeptidase 2 Homo sapiens 129-136 16004378-6 2005 Fumagillin is an irreversible inhibitor of methionine aminopeptidase type 2 (MetAP2). fumagillin 0-10 methionyl aminopeptidase 2 Homo sapiens 43-75 16004378-6 2005 Fumagillin is an irreversible inhibitor of methionine aminopeptidase type 2 (MetAP2). fumagillin 0-10 methionyl aminopeptidase 2 Homo sapiens 77-83 10636239-1 2000 New fumagillin analogues were designed through structure-based molecular modeling with a human methionine aminopeptidase-2. fumagillin 4-14 methionyl aminopeptidase 2 Homo sapiens 95-122 34913067-4 2022 Fumagillin and TNP-470, angiogenesis inhibitors that target MetAP2, significantly suppressed VM in various human cancer cell lines. fumagillin 0-10 methionyl aminopeptidase 2 Homo sapiens 60-66 34913067-7 2022 Collectively, our results demonstrate that MetAP2 is critical for VM in human cancer cells and suggest fumagillin and TNP-470 as potent VM-suppressing agents. fumagillin 103-113 methionyl aminopeptidase 2 Homo sapiens 43-49 33846894-5 2022 In search for potential reversible inhibitors, we built structure-based pharmacophore models using the crystal structure of MetAP2 complexed with fumagillin (PDB ID: 1BOA). fumagillin 146-156 methionyl aminopeptidase 2 Homo sapiens 124-130 9860943-10 1998 By using a fumagillin analog tagged with fluorescein, His-231 in MetAP2 was identified as the residue that is covalently modified by fumagillin. fumagillin 11-21 methionyl aminopeptidase 2 Homo sapiens 65-71 9860943-10 1998 By using a fumagillin analog tagged with fluorescein, His-231 in MetAP2 was identified as the residue that is covalently modified by fumagillin. fumagillin 133-143 methionyl aminopeptidase 2 Homo sapiens 65-71 9860943-12 1998 These results, in agreement with a recent structural study, suggest that fumagillin and ovalicin inhibit MetAP2 by irreversible blockage of the active site. fumagillin 73-83 methionyl aminopeptidase 2 Homo sapiens 105-111 32252002-4 2020 Clinical studies show that the natural product fumagillin, and its analogs are potential inhibitors of MetAP2. fumagillin 47-57 methionyl aminopeptidase 2 Homo sapiens 103-109 32252002-11 2020 Taken together, these uninherited-fumagillin compounds may serve as new class of inhibitors or provide scaffolds for further optimization towards the design of more potent MetAP2 inhibitors -development of such inhibitors would be essential strategy against various cancer types. fumagillin 34-44 methionyl aminopeptidase 2 Homo sapiens 172-178