PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34646138-12 2021 Kurarinone possesses stress-mediated anticancer activity and modulates STAT3 and Akt pathways. kurarinone 0-10 AKT serine/threonine kinase 1 Homo sapiens 81-84 29628889-6 2018 Mechanistically, kurarinone significantly decreased the ratio of Bcl-2/Bax, thereby causing the activation of caspase 9 and caspase 3, and reduced the expression of Grp78, which led to relieve the inhibition of caspase-12 and caspase-7, as well as suppressing the activity of AKT. kurarinone 17-27 AKT serine/threonine kinase 1 Homo sapiens 276-279 29628889-7 2018 Meanwhile, modeling results from the Surflex-Dock program suggested that residue Ser473 of Akt is a potential binding site for kurarinone. kurarinone 127-137 AKT serine/threonine kinase 1 Homo sapiens 91-94 29628889-9 2018 Our study indicated that kurarinone has the potential effects of anti-NSCLC, implemented through activating mitochondria apoptosis signaling pathway, as well as repressing the activity of endoplasmic reticulum pathway and AKT in A549 cells. kurarinone 25-35 AKT serine/threonine kinase 1 Homo sapiens 222-225