PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25524636-7 2015 The enhancement of apoptosis TRAIL induced by kurarinone involved downregulation of anti-apoptotic proteins Mcl-1 and c-FLIP as well as inhibition of STAT3 signaling. kurarinone 46-56 CASP8 and FADD like apoptosis regulator Homo sapiens 118-124 22932446-6 2012 On the other hand, kurarinone significantly inhibited TRAIL-induced IKK activation, IkappaB degradation and nuclear translocation of NF-kappaB, as well as effectively suppressed cellular FLICE-inhibitory protein long form (cFLIPL) expression. kurarinone 19-29 CASP8 and FADD like apoptosis regulator Homo sapiens 223-229 22932446-7 2012 The synergistic effects of kurarinone on TRAIL-induced apoptosis were mimicked when kurarinone was replaced by the NF-kappaB inhibitor withaferin A or following siRNA-mediated knockdown of cFLIPL. kurarinone 27-37 CASP8 and FADD like apoptosis regulator Homo sapiens 189-195