PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31319135-5 2019 Reduced expression of NADPH dehydrogenase quinone 1 (NQO-1) and heme oxygenase 1 (HO-1) genes, which are well-characterized downstream targets of Nrf2-mediated transactivation, was also confirmed by using ALA and another Nrf2 activator, marliolide. marliolide 237-247 NFE2 like bZIP transcription factor 2 Homo sapiens 146-150 31319135-8 2019 Interestingly, pretreatment of either ALA or marliolide conferred protection against the ROS induction and the subsequent development of cytotoxicity by menadione in both HaCaT and iHFK cells regardless of the Nrf2 status. marliolide 45-55 NFE2 like bZIP transcription factor 2 Homo sapiens 210-214 31319135-9 2019 These data suggest a possibility for activation of Nrf2-independent ROS detoxification pathways by either ALA or marliolide. marliolide 113-123 NFE2 like bZIP transcription factor 2 Homo sapiens 51-55 29525432-0 2018 Marliolide inhibits skin carcinogenesis by activating NRF2/ARE to induce heme oxygenase-1. marliolide 0-10 NFE2 like bZIP transcription factor 2 Homo sapiens 54-58 29525432-4 2018 Mechanism-based studies demonstrated that the induction of HO-1 by marliolide occurred through activation of NRF2/ARE via direct binding of marliolide to KEAP1. marliolide 67-77 NFE2 like bZIP transcription factor 2 Homo sapiens 109-113 29525432-4 2018 Mechanism-based studies demonstrated that the induction of HO-1 by marliolide occurred through activation of NRF2/ARE via direct binding of marliolide to KEAP1. marliolide 140-150 NFE2 like bZIP transcription factor 2 Homo sapiens 109-113