PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34186122-0	2021	Enhancement of interferon gamma stability as an anticancer therapeutic protein against hepatocellular carcinoma upon interaction with calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	134-143	interferon gamma	Homo sapiens	15-31	
34186122-5	2021	ANS/synchronous fluorescence, CD and UV-Vis spectroscopy studies indicated that the interaction between calycosin and IFN-gamma caused the folding of the IFN-gamma backbone in to a more packed structure with enhanced alpha-helix content and higher melting temperature (Tm) value.	7,3'-dihydroxy-4'-methoxyisoflavone	104-113	interferon gamma	Homo sapiens	154-163	
34186122-7	2021	It was also shown that after incubation of the IFN-gamma samples at 50  C for 60 min in the presence of calycosin (5 muM), the IFN-gamma-calycosin system showed a significant antiproliferative effects against hepatocellular carcinoma (HepG2) cells through caspase-9/3 activation and this anticancer effect was more pronounced than free IFN-gamma.	7,3'-dihydroxy-4'-methoxyisoflavone	104-113	interferon gamma	Homo sapiens	47-56	
34186122-7	2021	It was also shown that after incubation of the IFN-gamma samples at 50  C for 60 min in the presence of calycosin (5 muM), the IFN-gamma-calycosin system showed a significant antiproliferative effects against hepatocellular carcinoma (HepG2) cells through caspase-9/3 activation and this anticancer effect was more pronounced than free IFN-gamma.	7,3'-dihydroxy-4'-methoxyisoflavone	104-113	interferon gamma	Homo sapiens	127-136	
34186122-2	2021	Herein, we explored the thermodynamic parameters and conformational stability of IFN-gamma in the presence of calycosin, the main active compound of Radix astragali, by different biophysical and theoretical analysis.	7,3'-dihydroxy-4'-methoxyisoflavone	110-119	interferon gamma	Homo sapiens	81-90	
34186122-4	2021	ITC data indicated that upon interaction of calycosin with IFN-gamma the binding and thermodynamic parameters were as follows: Kd = 1.9 muM, DeltaG  = -32.45 kJ/mol, DeltaH  = -11.91 kJ/mol, and TDeltaS  = 20.54 kJ/mol.	7,3'-dihydroxy-4'-methoxyisoflavone	44-53	interferon gamma	Homo sapiens	59-68	
34186122-5	2021	ANS/synchronous fluorescence, CD and UV-Vis spectroscopy studies indicated that the interaction between calycosin and IFN-gamma caused the folding of the IFN-gamma backbone in to a more packed structure with enhanced alpha-helix content and higher melting temperature (Tm) value.	7,3'-dihydroxy-4'-methoxyisoflavone	104-113	interferon gamma	Homo sapiens	118-127