PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32106002-11	2020	Further mechanistic study suggests that induction of the Raf/MEK/ERK pathway and facilitated polarization of M2 tumor-associated macrophage in the tumor microenvironment both contribute to the pro-metastatic potential of calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	221-230	mitogen-activated protein kinase 1	Homo sapiens	65-68	
32999213-6	2020	In conclusion, calycosin may alleviate Ang II-induced pro-proliferative and anti-apoptotic effects on glomerular mesangial cells at least partially via inhibiting autophagy and ERK signaling pathway, suggesting that calycosin may function as a potential alternative medication for the management of chronic kidney diseases.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	mitogen-activated protein kinase 1	Homo sapiens	177-180	
32999213-0	2020	Calycosin may alleviate Ang II-induced pro-proliferative effects on glomerular mesangial cells via partially inhibiting autophagy and ERK signaling pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	mitogen-activated protein kinase 1	Homo sapiens	134-137	
32999213-5	2020	We found that Ang II increased viability and proliferation, meanwhile inhibited apoptosis of the GMCs; furthermore, 1 and 10 muM calycosin significantly inhibited the growth and promoted the apoptosis of the GMCs treated by Ang II; moreover, calycosin also inhibited ERK signaling in mesangial cells activated by Ang II treatment; Finally, calycosin could inhibit Ang II induced autophagy of GMCs in a dose-dependent manner.	7,3'-dihydroxy-4'-methoxyisoflavone	129-138	mitogen-activated protein kinase 1	Homo sapiens	267-270	
29449812-8	2018	In cultured osteoblasts, the DBT-activated Wnt/beta-catenin and MAPK/Erk and signaling pathways were greatly affected when calycosin was depleted.	7,3'-dihydroxy-4'-methoxyisoflavone	123-132	mitogen-activated protein kinase 1	Homo sapiens	69-72	
24618835-0	2014	Calycosin suppresses breast cancer cell growth via ERbeta-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	mitogen-activated protein kinase 1	Homo sapiens	90-93