PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30182951-9	2018	In MG-63 cells, calycosin treatment increased the expression of the PI3K/AKT/mTOR pathway proteins; inhibitor assays showed that expression of the PI3K protein was most strongly associated with the antitumor effects of calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	16-25	mechanistic target of rapamycin kinase	Homo sapiens	77-81	
31276230-0	2019	Calycosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	mechanistic target of rapamycin kinase	Homo sapiens	138-142	
31276230-13	2019	In conclusion, Calycosin stimulates CRC cell apoptosis and inhibits their invasion by acting as SIRT1 activator which induces activation of AMPK-induced inhibition of Akt/mTOR axis.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	mechanistic target of rapamycin kinase	Homo sapiens	171-175	
30182951-0	2018	Calycosin, a Phytoestrogen Isoflavone, Induces Apoptosis of Estrogen Receptor-Positive MG-63 Osteosarcoma Cells via the Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	mechanistic target of rapamycin kinase	Homo sapiens	161-190	
30182951-0	2018	Calycosin, a Phytoestrogen Isoflavone, Induces Apoptosis of Estrogen Receptor-Positive MG-63 Osteosarcoma Cells via the Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	mechanistic target of rapamycin kinase	Homo sapiens	192-196	
30182951-9	2018	In MG-63 cells, calycosin treatment increased the expression of the PI3K/AKT/mTOR pathway proteins; inhibitor assays showed that expression of the PI3K protein was most strongly associated with the antitumor effects of calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	219-228	mechanistic target of rapamycin kinase	Homo sapiens	77-81	
30182951-11	2018	CONCLUSIONS The phytoestrogen, calycosin, induced apoptosis of cells of the ER-positive osteosarcoma cell line, MG-63, via the PI3K/AKT/mTOR pathway, with these effects being mainly due to PI3K.	7,3'-dihydroxy-4'-methoxyisoflavone	31-40	mechanistic target of rapamycin kinase	Homo sapiens	136-140