PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28596571-3 2017 The aim of the present study is to test whether calycosin protects against cerebral ischemic injury through TRPC6-CREB pathway. 7,3'-dihydroxy-4'-methoxyisoflavone 48-57 cAMP responsive element binding protein 1 Rattus norvegicus 114-118 28596571-7 2017 The neuroprotection effect of calycosin was diminished by inhibition or knockdown of TRPC6 and CREB. 7,3'-dihydroxy-4'-methoxyisoflavone 30-39 cAMP responsive element binding protein 1 Rattus norvegicus 95-99 28596571-8 2017 These findings indicated that the potential neuroprotection mechanism of calycosin was involved with TRPC6-CREB pathway. 7,3'-dihydroxy-4'-methoxyisoflavone 73-82 cAMP responsive element binding protein 1 Rattus norvegicus 107-111 28596571-6 2017 Our results showed that treatment with calycosin protected against ischemia-induced damages by increasing TRPC6 and P-CREB expression and inhibiting calpain activation. 7,3'-dihydroxy-4'-methoxyisoflavone 39-48 cAMP responsive element binding protein 1 Rattus norvegicus 118-122