PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27551099-7	2016	We also found that intracellular infusion of a selective PKCalpha inhibitor (Go6976) blocked LTD induction in the mutants, as in WT, suggesting that functional compensation occurred downstream of PKCalpha.	Go 6976	77-83	protein kinase C, alpha	Mus musculus	57-65	
27770660-6	2016	Selective inhibition of PKC alpha/beta II using Go6976 or siRNA abolished the CA-induced Nrf-2/HO-1 signaling, and consequently suppressed the cytoprotective activity of CA on the LPS-induced cell death.	Go 6976	48-54	protein kinase C, alpha	Mus musculus	24-41	
27551099-7	2016	We also found that intracellular infusion of a selective PKCalpha inhibitor (Go6976) blocked LTD induction in the mutants, as in WT, suggesting that functional compensation occurred downstream of PKCalpha.	Go 6976	77-83	protein kinase C, alpha	Mus musculus	196-204	
27142955-3	2016	We used 2 different approaches: blockade of biological activity of PKCalpha by intraperitoneal application of the conventional PKC inhibitor Go6976 in C57BL/6 wild-type mice and PKCalpha-deficient mice on a 129/Sv genetic background.	Go 6976	141-147	protein kinase C, alpha	Mus musculus	67-75	
27131602-7	2016	Additionally, treatment with Go6976 blocked the effect of t10-c12CLA on perilipin-1 phosphorylation, implicating PKCalpha in perilipin-1 phosphorylation, and thus a regulator of triglyceride catabolism.	Go 6976	29-35	protein kinase C, alpha	Mus musculus	113-121	
20973912-6	2011	Pre-treatment of pancreatic acinar cells with Go6976 (1-10 nM) and rottlerin (1-10 muM) inhibited PKC-alpha and PKC-delta phosphorylation, respectively, but not the other way round.	Go 6976	46-52	protein kinase C, alpha	Mus musculus	98-107	
26190181-7	2015	Treatment of cells with 1 muM Go 6976, a Ca(2+)-specific PKC inhibitor reduced Ca(2+) mobilization and membrane-associated PKCalpha and p-PKCalpha in both cell types.	Go 6976	30-37	protein kinase C, alpha	Mus musculus	57-60	
26190181-7	2015	Treatment of cells with 1 muM Go 6976, a Ca(2+)-specific PKC inhibitor reduced Ca(2+) mobilization and membrane-associated PKCalpha and p-PKCalpha in both cell types.	Go 6976	30-37	protein kinase C, alpha	Mus musculus	123-131	
26190181-7	2015	Treatment of cells with 1 muM Go 6976, a Ca(2+)-specific PKC inhibitor reduced Ca(2+) mobilization and membrane-associated PKCalpha and p-PKCalpha in both cell types.	Go 6976	30-37	protein kinase C, alpha	Mus musculus	138-146	
23977428-12	2013	Go6976 (100 nM), a PKCalpha inhibitor, abolished the effect of CCPA to inhibit BK current (99+-3% of control).	Go 6976	0-6	protein kinase C, alpha	Mus musculus	19-27	
23402219-7	2014	However, in the presence of a selective classical PKC isoform inhibitor, Go6976, proplatelet formation was conversely enhanced.	Go 6976	73-79	protein kinase C, alpha	Mus musculus	50-53	
23220724-9	2013	To determine if PKC is involved in aldosterone-induced O(2)(-) production, we exposed the O(2)(-) cells to a nonselective PKC inhibitor chelerythrine chloride, a specific PKCalpha inhibitor Go6976, or a PKCalpha siRNA, and the aldosterone-induced increase in O(2)(-) production was blocked.	Go 6976	190-196	protein kinase C, alpha	Mus musculus	171-179	
23028752-5	2012	However, the induced effect of FSH was dose-dependently inhibited by the specific PKC alpha and betaI inhibitor Go6976, and 100 nM Go6976 completely blocked FSH function in oocyte meiotic resumption.	Go 6976	112-118	protein kinase C, alpha	Mus musculus	82-91	
23028752-5	2012	However, the induced effect of FSH was dose-dependently inhibited by the specific PKC alpha and betaI inhibitor Go6976, and 100 nM Go6976 completely blocked FSH function in oocyte meiotic resumption.	Go 6976	131-137	protein kinase C, alpha	Mus musculus	82-91	
21705673-8	2011	Finally, we found that ACh-induced vasodilation was inhibited by the PKCalpha inhibitor Go-6976 in small mesenteric arteries from wild-type mice, but not in TRPV4 null mice.	Go 6976	88-95	protein kinase C, alpha	Mus musculus	69-77	
20951242-5	2011	Treatment with Go6976, an inhibitor of PKCalpha and PKCbetaI, increased alkaline phosphatase (ALP) activity as well as gene expression of ALP and Osteocalcin (OCN), and enhanced calcification of the extracellular matrix.	Go 6976	15-21	protein kinase C, alpha	Mus musculus	39-47	
21473788-12	2011	Inhibition of conventional PKC by Go6976 mitigated the TNF-alpha-induced p115RhoGEF phosphorylation and RhoA activation.	Go 6976	34-40	protein kinase C, alpha	Mus musculus	27-30	
20053794-10	2010	The PKC-alpha- and betaI-selective inhibitor Go 6976 (100 nM) decreased flow-stimulated net O(2)(-) production from 54 +/- 15 to 2 +/- 1 AU/s (P < 0.04; n = 5).	Go 6976	45-52	protein kinase C, alpha	Mus musculus	4-13	
20417251-6	2010	Intrathecal pretreatment with inhibitors (Go6976, PKCepsilonV1-2 or PKC zetapseudosubstrate) of the PKCalpha, epsilon or zeta isoforms significantly reduced the PRE-induced pain facilitatory effect.	Go 6976	42-48	protein kinase C, alpha	Mus musculus	100-108	
19592614-9	2009	These effects of ENBA were blocked by Go-6976 (PKC-alpha inhibitor) and PD-98059 (p42/p44 MAPK inhibitor).	Go 6976	38-45	protein kinase C, alpha	Mus musculus	47-56	
16740968-3	2006	After a 3-d treatment with 3 nm Go6976, a specific inhibitor of classical PKC isoforms, cells were characterized by the presence of one elongated process similar to that observed after treatment with Ang II or with CGP42112, a selective AT2 receptor agonist.	Go 6976	32-38	protein kinase C, alpha	Mus musculus	74-77	
19403597-6	2009	Inhibition of PKCalpha and PKCbeta with Go6976 had no effect.	Go 6976	40-46	protein kinase C, alpha	Mus musculus	14-22	
18367332-7	2008	We found that knocking out PS1 or PS2 alone resulted in increased Erk activity and that this effect could be reversed by the PKCalpha inhibitor Go6976.	Go 6976	144-150	protein kinase C, alpha	Mus musculus	125-133	
16740968-8	2006	Incubation of NG108-15 cells with Go6976 (3 nm) inhibited basal p42/p44(mapk) phosphorylation, but failed to interfere with its activation by the AT(2) receptor, indicating that inhibition of PKC alpha is not directly involved in the Rap1-MEK-p42/p44(mapk) cascade.	Go 6976	34-40	protein kinase C, alpha	Mus musculus	192-201	
11841365-8	2002	Go 6976, an inhibitor of calcium-dependent (conventional) PKC, proved to promote hair epithelial cell growth.	Go 6976	0-7	protein kinase C, alpha	Mus musculus	58-61	
15161371-6	2004	In addition, Go6976, a classical PKC (cPKC) inhibitor, which specifically inhibits PKC (alpha and betaI), also promoted apoptosis.	Go 6976	13-19	protein kinase C, alpha	Mus musculus	33-36	
15161371-6	2004	In addition, Go6976, a classical PKC (cPKC) inhibitor, which specifically inhibits PKC (alpha and betaI), also promoted apoptosis.	Go 6976	13-19	protein kinase C, alpha	Mus musculus	39-42	
12093473-5	2002	The zymosan-induced increase in iPLA2 activity was suppressed by pretreatment with 4beta-phorbol 12-myristate 13-acetate for 10 hr, by which PKCalpha and PKCdelta, but not PKCbeta and PKCepsilon, were depleted, and by Go6976, a PKCalpha inhibitor, but not rottlerin, a PKCdelta inhibitor.	Go 6976	218-224	protein kinase C, alpha	Mus musculus	141-149	
15198639-7	2004	Inhibition of PKC-alpha with Go6976 had no effect on cell number in the zinc-deficient group.	Go 6976	29-35	protein kinase C, alpha	Mus musculus	14-23	
15262987-4	2004	The PKC inhibitors bisindolymaleimide I and Go6976, blocked CREB phosphorylation.	Go 6976	44-50	protein kinase C, alpha	Mus musculus	4-7	
15150589-3	2004	Proteasome expression induced by PIF was attenuated by 4alpha-phorbol 12-myristate 13-acetate (100 nM) and by the PKC inhibitors Ro31-8220 (10 microM), staurosporine (300 nM), calphostin C (300 nM) and Go 6976 (200 microM).	Go 6976	202-209	protein kinase C, alpha	Mus musculus	114-117	
34078525-7	2021	Similar results were obtained from the mouse embryonic fibroblasts exposed to a PKCalpha inhibitor, Go6976.	Go 6976	100-106	protein kinase C, alpha	Mus musculus	80-88	
11483412-4	2001	In addition, the effect of PKCalpha inhibitor Go6976 on the SPP-induced PLD activation in myoblasts, where RhoA function was inactivated, was consistent with a dual regulation of the enzyme through RhoA and PKCalpha.	Go 6976	46-52	protein kinase C, alpha	Mus musculus	27-35	
11488451-9	2001	A significant reduction of the euxanthone-induced neuritogenic effect was also observed when the PKC isoform-specific inhibitor Go6976 was included in the culture.	Go 6976	128-134	protein kinase C, alpha	Mus musculus	97-100	
11278470-4	2001	Here, we report that treatment of Swiss 3T3 cells with Go6976, a selective inhibitor of PKC alpha, caused a sustained elevation of IGF-I-stimulated nuclear PLC activity.	Go 6976	55-61	protein kinase C, alpha	Mus musculus	88-97	
32783140-6	2020	Similar to Calphostin C, PKC alpha and betaI inhibitor Go6976 exposure also reduced ASIC1a protein expression.	Go 6976	55-61	protein kinase C, alpha	Mus musculus	11-44