PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33818279-6 2022 The NOX/PHOX (NADPH oxidase)-dependent oxidative burst was required for nuclear translocation of TFEB during phagocytosis of Gram-positive or -negative bacteria, and reactive oxygen species (ROS) were sufficient to trigger TFEB activation in a CD38- and NAADP (nicotinic acid adenine dinucleotide phosphate)-dependent manner. NAADP 254-259 transcription factor EB Homo sapiens 97-101 33818279-6 2022 The NOX/PHOX (NADPH oxidase)-dependent oxidative burst was required for nuclear translocation of TFEB during phagocytosis of Gram-positive or -negative bacteria, and reactive oxygen species (ROS) were sufficient to trigger TFEB activation in a CD38- and NAADP (nicotinic acid adenine dinucleotide phosphate)-dependent manner. NAADP 261-306 transcription factor EB Homo sapiens 97-101 33818279-7 2022 Consistent with the Ca2+-releasing activity of NAADP, intracellular Ca2+ chelation and PPP3/calcineurin inhibition prevented TFEB activation by phagocytosis and ROS (reactive oxygen species), impairing the induction of pro-inflammatory cytokines such as IL6 and TNF/TNFalpha. NAADP 47-52 transcription factor EB Homo sapiens 125-129 34313548-8 2022 This generates an NAADP-dependent calcium signal, which requires LRRK2 kinase activity, and results in the downstream activation of TFEB. NAADP 18-23 transcription factor EB Homo sapiens 132-136