PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24357089-6 2014 The PG/PK study of indapamide demonstrated that the polymorphic SNPs CYP2C9 rs4918758 and CYP2C19 rs4244285 appeared to confer lowered enzyme activity, as indicated by increased C max (25% ~ 64%), increased area under the plasma level-time curves (30~76%), increased area under the time infinity (43% ~ 80%), and lower apparent clearance values than PK for wild-type indapamide. Indapamide 19-29 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 69-75 24357089-6 2014 The PG/PK study of indapamide demonstrated that the polymorphic SNPs CYP2C9 rs4918758 and CYP2C19 rs4244285 appeared to confer lowered enzyme activity, as indicated by increased C max (25% ~ 64%), increased area under the plasma level-time curves (30~76%), increased area under the time infinity (43% ~ 80%), and lower apparent clearance values than PK for wild-type indapamide. Indapamide 367-377 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 69-75 24357089-7 2014 Our results reinforce the biochemical support of CYP2C19 in indapamide metabolism and identify a possible new participating enzyme CYP2C9. Indapamide 60-70 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 131-137