PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22579001-9 2012 CYP3A4 and CYP2C19 were involved in indapamide metabolism in human live microsomes. Indapamide 36-46 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-6 19074530-0 2009 Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions. Indapamide 48-102 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 119-125 19074530-0 2009 Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions. Indapamide 104-114 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 119-125 19074530-6 2009 Here we identified several indapamide metabolic pathways in vitro with human liver microsomes and recombinant CYP3A4 that include the dehydrogenation of indapamide to its corresponding indole form, and also hydroxylation and epoxidation metabolites, as characterized by liquid chromatography/mass spectrometry. Indapamide 27-37 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 110-116 19074530-6 2009 Here we identified several indapamide metabolic pathways in vitro with human liver microsomes and recombinant CYP3A4 that include the dehydrogenation of indapamide to its corresponding indole form, and also hydroxylation and epoxidation metabolites, as characterized by liquid chromatography/mass spectrometry. Indapamide 153-163 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 110-116 19074530-7 2009 Indapamide dehydrogenation efficiency (V(max)/K(m)=204 min/mM) by CYP3A4 was approximately 10-fold greater than that of indoline dehydrogenation. Indapamide 0-10 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 66-72