PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14528063-6	2003	The NAT2 phenotype was evaluated with dapsone as a test substrate using high-pressure liquid chromatography.	Dapsone	38-45	N-acetyltransferase 2	Homo sapiens	4-8	
7600914-9	1995	The apparent KM of dapsone acetylation by bacterially expressed NAT1 and NAT2 enzymes was 687 and 136 microM, respectively.	Dapsone	19-26	N-acetyltransferase 2	Homo sapiens	73-77	
31285712-0	2019	Determination of Arylamine N-Acetyltransferase 2 Acetylation Genotype by PCR and Phenotyping Using Dapsone Through High-Pressure Liquid Chromatography Assay: A Gender Wise Study.	Dapsone	99-106	N-acetyltransferase 2	Homo sapiens	17-48	
31285712-10	2019	Therefore, it is concluded that NAT2 acetylation rate can be used to check in vivo acetylation status with dapsone as probe drug.	Dapsone	107-114	N-acetyltransferase 2	Homo sapiens	32-36	
31285712-11	2019	It is concluded that NAT2 acetylation rate was unaffected by gender and can be used to check in vivo acetylation status with dapsone as probe drug, which is inexpensive and less time-consuming.	Dapsone	125-132	N-acetyltransferase 2	Homo sapiens	21-25	
30472588-2	2019	In this study, we used a cocktail of bupropion, losartan and dapsone for in vivo phenotyping of CYP2B6, CYP2C9 and N-acetyltransferase-2 (NAT2) in plasma.	Dapsone	61-68	N-acetyltransferase 2	Homo sapiens	138-142	
30472588-14	2019	CONCLUSIONS: This study advocates the use of a cocktail of bupropion, losartan and dapsone for in vivo phenotyping of CYP2B6, CYP2C9 and NAT2, which is important in determining therapeutic dose levels of anti-HIV and anti-TB drugs in HIV/AIDS-TB coinfections.	Dapsone	83-90	N-acetyltransferase 2	Homo sapiens	137-141	
15999287-5	2005	Further investigation revealed a marked decrease of the enzyme activity of N-acetyltransferase 2, which plays an important role in dapsone metabolism.	Dapsone	131-138	N-acetyltransferase 2	Homo sapiens	75-96	
10589083-3	1999	Dapsone is partly metabolized by the polymorphic N-acetyltransferase 2% and 50% of Caucasian patients show a genetically determined slow acetylator phenotype.	Dapsone	0-7	N-acetyltransferase 2	Homo sapiens	49-70	
7669073-5	1995	The apparent Km values (at 100 microM acetyl CoA as co-substrate) of the different NAT2 variants for sulphamethazine, dapsone, p-anisidine, 2-aminofluorene, procainamide and isoniazid were determined.	Dapsone	118-125	N-acetyltransferase 2	Homo sapiens	83-87	
7669073-7	1995	The apparent Km for the structurally related sulphone antibiotic dapsone was 5-fold lower for the slow variant NAT2 7B when compared with the wild-type NAT2 4.	Dapsone	65-72	N-acetyltransferase 2	Homo sapiens	111-115	
7669073-7	1995	The apparent Km for the structurally related sulphone antibiotic dapsone was 5-fold lower for the slow variant NAT2 7B when compared with the wild-type NAT2 4.	Dapsone	65-72	N-acetyltransferase 2	Homo sapiens	152-156	
7669073-8	1995	These results indicate that the NAT2 7B specific amino acid substitution, Gly286-Glu, is important in promoting the binding of sulphamethazine and dapsone to the active site.	Dapsone	147-154	N-acetyltransferase 2	Homo sapiens	32-36	
28322460-0	2017	Dapsone-induced agranulocytosis-possible involvement of low-activity N-acetyltransferase 2.	Dapsone	0-7	N-acetyltransferase 2	Homo sapiens	69-90