PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28515436-0	2017	Nimbolide upregulates RECK by targeting miR-21 and HIF-1alpha in cell lines and in a hamster oral carcinogenesis model.	nimbolide	0-9	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	22-26	
28515436-8	2017	Taken together, these findings provide compelling evidence that targeting RECK, a keystone protein that regulates mediators of invasion and angiogenesis with phytochemicals such as nimbolide may be a robust therapeutic approach to prevent oral cancer progression.	nimbolide	181-190	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	74-78	
28515436-3	2017	We also report the chemotherapeutic effect of nimbolide, a limonoid from the neem tree (Azadirachta indica) based on the upregulation of RECK as well as modulation of the expression of key molecules involved in invasion and angiogenesis.	nimbolide	46-55	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	137-141	
28515436-4	2017	We demonstrate that nimbolide upregulates RECK by targeting miR-21, and HIF-1alpha resulting in reduced MMP activity and blockade of VEGF and Notch signalling.	nimbolide	20-29	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	42-46	
28515436-7	2017	Additionally, we demonstrate that nimbolide upregulates RECK expression via downregulation of HIF-1alpha and miR-21 by overexpression and knockdown experiments in SCC4 and EAhy926 cell lines.	nimbolide	34-43	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	56-60