PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32568522-0 2020 A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL. nimbolide 2-11 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 68-75 32568522-5 2020 We demonstrate that a PROTAC linking nimbolide to the kinase and BCR-ABL fusion oncogene inhibitor dasatinib, BT1, selectively degrades BCR-ABL over c-ABL in leukemia cancer cells, compared to previously reported cereblon or VHL-recruiting BCR-ABL degraders that show opposite selectivity or in some cases inactivity. nimbolide 37-46 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 65-72 32568522-5 2020 We demonstrate that a PROTAC linking nimbolide to the kinase and BCR-ABL fusion oncogene inhibitor dasatinib, BT1, selectively degrades BCR-ABL over c-ABL in leukemia cancer cells, compared to previously reported cereblon or VHL-recruiting BCR-ABL degraders that show opposite selectivity or in some cases inactivity. nimbolide 37-46 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 136-143 32568522-5 2020 We demonstrate that a PROTAC linking nimbolide to the kinase and BCR-ABL fusion oncogene inhibitor dasatinib, BT1, selectively degrades BCR-ABL over c-ABL in leukemia cancer cells, compared to previously reported cereblon or VHL-recruiting BCR-ABL degraders that show opposite selectivity or in some cases inactivity. nimbolide 37-46 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 149-154 32568522-5 2020 We demonstrate that a PROTAC linking nimbolide to the kinase and BCR-ABL fusion oncogene inhibitor dasatinib, BT1, selectively degrades BCR-ABL over c-ABL in leukemia cancer cells, compared to previously reported cereblon or VHL-recruiting BCR-ABL degraders that show opposite selectivity or in some cases inactivity. nimbolide 37-46 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 136-143